Is really endogenous ghrelin a hunger signal in chickens? Association of GHSR SNPs with increase appetite, growth traits, expression and serum level of GHRL, and GH

El-Magd, Mohammed A.; Saleh, Ayman A.; Abdel-Hamid, Tamer M.; Saleh, Rasha M.; Afifi, Mohamed

doi:10.1016/j.ygcen.2016.08.016

Cited by 22 publications

(9 citation statements)

References 43 publications

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“…The poultry production is the quickest way to produce protein of high quality for human consumption. 1,2 Broiler chickens require about 3 kg of ration to create 1 kg of meat, but animals need 7 kg of food tom produce of red meat. 3 So in this inquiry, we enhance growth and immunity of broiler chickens to enhance meat production of good quality.…”

Section: Introductionmentioning

confidence: 99%

Effects of calf thymus extract and L-carnitine on immunity and growth performance of broiler chickens

2020

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Background: Increasing the bird’s wealth and increasing the growth rate are among the goals of increasing the animal wealth so; we studied the effects of L-carnitine and calf thymus extract on growth performance and immunity in broiler chickens.Methods: Eighty broiler chicks were divided into four groups, each group included twenty chicks. Group 1, was negative control with no treatment of feed or water. Group 2, the regular drinking water was replaced by L-carnitine-infused water (1 gram per liter). Group 3, the regular drinking water was replaced by calf thymus extract- infused water (1 ml per liter). Group 4, the regular drinking water was replaced by both L-carnitine and calf thymus extract- infused water. This treatment was administered from day 1 to day 30 of the cycle. Body weight, feed intake and feed conversion were assessed. The hemogram, leuckogram, total protein, globulin, albumin, phagocytic activity, phagocytic index and interleukin 2 were measured. Results: The hemogram and leuckogram parameters recorded a significant increase in treated groups compared to non treated group. The final body weight for all treatments was nearly the same, but slightly higher with application of L-carnitine. Phagocytic activity, index, TP, globulin and IL2 were significantly increased in treated groups.Conclusions: Both L-carnitine and thymus extract have significantly improved the general health condition, in addition, calf thymus extract improved not only the general body condition but also act has immunomodulatory effect which require more further studies.

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Section: Introductionmentioning

confidence: 99%

Effects of calf thymus extract and L-carnitine on immunity and growth performance of broiler chickens

2020

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“…SNPs genotyping was done by SSCP which was carried out as previously described [18,19]. Animals were genotyped based on the pattern of SSCP bands.…”

Section: Snps Detection and Genotypingmentioning

confidence: 99%

Association of GHR Polymorphisms with Milk Production in Buffaloes

El-Komy

Saleh

Abdel-Hamid

et al. 2020

Animals

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For its role in the mediation of growth hormone (GH) galactopoietic effect, growth hormone receptor (GHR) was considered a functional candidate gene for milk performance in cattle. However, its genetic variation and potential effect have not been investigated in Egyptian buffaloes. This study aimed to screen GHR for polymorphisms and study their associations with milk traits in Egyptian buffaloes. Polymerase chain reaction, single-strand conformation polymorphism, and sequencing were used to identify mutations in 4 exons (E4–E6 and E8) of the GHR gene in 400 Egyptian buffaloes. No polymorphisms were found in E4, while 2 SNPs (c.380G>A/p.Arg127Lys and c.387C>T/p.Gly129) in E5, one silent mutation (c.435A>G/p.Pro145) in E6, and another missense mutation (c.836T>A/p.Phe279Tyr) in E8 were detected. The c.380G>A SNP in the extracellular domain was associated with milk yield, fat %, protein %, and 305-day milk, fat and protein yield, with higher levels in animals carrying the mutant A allele. The c.836T>A SNP in the transmembrane domain was associated with milk yield, fat %, protein %, and 305-day milk, fat and protein yield, with higher milk yield and lower fat %, protein %, fat and protein yield in the mutant A allele-animals. Interestingly, animals with the two mutant AA alleles produced higher milk yield, fat %, protein %, fat and protein yield, accompanied with upregulated expressions of GHR, GH, insulin-like growth factor 1 (IGF1), prolactin (PRL), prolactin receptor (PRLR), β-casein (encoded by CSN2 gene), and diacylglycerol acyltransferase-1 (DGAT1) genes and proteins in milk somatic cells. Therefore, selection of Egyptian buffaloes with mutant AA haplotypes for the novel c.380G>A SNP and the well-known c.836T>A SNP could improve milk yield and quality in buffaloes.

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“…Ghrelin can induce the contraction of the chicken crop, proventriculus, ileum and colon, and speed up gastric emptying, but this function is negative with the age of chicken [ 52 , 53 ]. El-Magd et al [ 54 ] indicated that the mRNA expression of the ghrelin receptor is positively related to chicken feed intake and can induce chicken growth hormone production.…”

Section: The Endocrine Regulation Of the Avian Appetitementioning

confidence: 99%

Evaluation of the Relationship between Adipose Metabolism Patterns and Secretion of Appetite-Related Endocrines on Chicken

Chuang

Hsieh

Chen

et al. 2020

Animals

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In addition to the influence of genes, the quality of poultry products is mainly controlled by the rearing environment or feed composition during rearing, and has to meet human use and economical needs. As the only source of energy for poultry, feed considerably affects the metabolic pattern of poultry and further affects the regulation of appetite-related endocrine secretion in poultry. Under normal circumstances, the accumulation of lipid in adipose reduces feed intake in poultry and increases the rate of adipose metabolism. When the adipose content in cells decreases, endocrines that promote food intake are secreted and increase nutrient concentrations in serum and cells. By regulating the balance between appetite and adipose metabolism, the poultry’s growth and posture can maintain a balanced state. In addition, increasing fiber composition in feed can effectively increase poultry welfare, body weight, lean composition and antioxidant levels in poultry. According to this, the concept that proper fiber content should be added to feed should be considered for better economic benefits, poultry welfare and meat productivity.

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Is really endogenous ghrelin a hunger signal in chickens? Association of GHSR SNPs with increase appetite, growth traits, expression and serum level of GHRL, and GH

Cited by 22 publications

References 43 publications

Effects of calf thymus extract and L-carnitine on immunity and growth performance of broiler chickens

Effects of calf thymus extract and L-carnitine on immunity and growth performance of broiler chickens

Association of GHR Polymorphisms with Milk Production in Buffaloes

Evaluation of the Relationship between Adipose Metabolism Patterns and Secretion of Appetite-Related Endocrines on Chicken

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