Is reactive airways dysfunction syndrome a variant of occupational asthma?

Gautrin, Denyse; Boulet, Louis‐Philippe; Boutet, M; Dugas, M; Bhérer, Luc; L’Archevêque, Jocelyne; Laviolette, Michel; Côté, Johanne; Malo, Jean‐Luc

doi:10.1016/0091-6749(94)90228-3

Cited by 121 publications

(73 citation statements)

References 21 publications

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“…The predominantly lymphocytic inflammation found in the biopsy was in accordance with earlier observations of chronic RADS (7,8). In addition, the lymphocytosis found in the bronchoalveolar lavage fluid was consistent with the findings of Gautrin et al (39) in the chronic stage of RADS.…”

Section: Discussionsupporting

confidence: 91%

Prolonged respiratory symptoms caused by thermal degradation products of freons

Piirilä

Espo²,

Pfäffli³

et al. 2003

Scand J Work Environ Health

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Section: Discussionsupporting

confidence: 91%

Prolonged respiratory symptoms caused by thermal degradation products of freons

Piirilä

Espo²,

Pfäffli³

et al. 2003

Scand J Work Environ Health

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“…Symptoms and hyperresponsiveness, often called the reactive airways dysfunction syndrome (RADS), may develop after a single intense inhalational exposure to a respiratory irritant such as an acid or alkali (49). Although the clinical symptoms mimic asthma, the airway pathology associated with RADS may be distinguishable from the airway inflammation typically associated with asthma (50). A similar syndrome of persistent asthmalike symptoms has been observed among pulp mill workers who experienced repeated but less intense exposures to chlorine gas (51,52).…”

Section: Irritant-induced Asthmamentioning

confidence: 88%

Work-related asthma and implications for the general public.

Petsonk

2002

Environ Health Perspect

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“…After the initial event, the reversibility of airway obstruction is not as constant and as marked in subjects with RADS as in those with OA or nonoccupational asthma. Moreover, the chronic pathological features point to more airway remodelling than for standard asthma [29,30]. That said, there is still sufficient clinical and functional evidence for accepting RADS as a category of asthma causally related to workplace exposure.…”

Section: Sensitising Nature Of the Processmentioning

confidence: 99%

Definitions and types of work-related asthma: a nosological approach

Vandenplas¹,

Jl²

2003

Eur Respir J

109

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The workplace can trigger or induce asthma and cause the onset of different types of work-related asthma. Analysis of previous definitions of occupational asthma (OA) led to the conclusion that evidence of a direct causal relationship between workplace exposure and the development of asthma remains the key element for defining OA.Based on clinical features and pathophysiological mechanisms, the following conditions should be distinguished in the spectrum of work-related asthma: 1) immunological OA characterised by a latency period necessary to acquire immunologically induced sensitisation; 2) nonimmunological OA characterised by the rapid onset of asthma following single or multiple exposures to high concentrations of irritant compounds; 3) work-related asthma defined by exacerbation of symptoms in workers with pre-existing or coincident asthma; and 4) variant syndromes including eosinophilic bronchitis, potroom asthma, and asthma-like disorders caused by organic dusts.The issues and controversies relating to this approach are critically reviewed in order to stimulate the consensus development of operational definitions of work-related asthma. Eur Respir J 2003; 21: 706-712.

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Is reactive airways dysfunction syndrome a variant of occupational asthma?

Cited by 121 publications

References 21 publications

Prolonged respiratory symptoms caused by thermal degradation products of freons

Prolonged respiratory symptoms caused by thermal degradation products of freons

Work-related asthma and implications for the general public.

Definitions and types of work-related asthma: a nosological approach

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