Is Radiotherapy a Good Adjuvant Strategy for Men With a History of Cryptorchism and Stage I Seminoma?

Martin, Jarad; Gorayski, Peter; Zwahlen, Daniel R.; Fay, Michael; Keller, Jacqui; Millar, Jeremy

doi:10.1016/j.ijrobp.2009.01.027

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…With regard to fixation sutures, if required, they should be made between the tunica vaginalis and the dartos musculature [44]. Lymph drainage of a testis that has undergone surgery for orchidopexy may have changed from high retroperitoneal drainage to iliac and inguinal drainage, which might become important in the event of later malignancy [45].…”

Section: Surgical Therapymentioning

confidence: 99%

Management of undescended testes: European Association of Urology/European Society for Paediatric Urology Guidelines

Radmayr

Doğan

Hoebeke

et al. 2016

Journal of Pediatric Urology

167

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Section: Surgical Therapymentioning

confidence: 99%

Management of undescended testes: European Association of Urology/European Society for Paediatric Urology Guidelines

Radmayr

Doğan

Hoebeke

et al. 2016

Journal of Pediatric Urology

167

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“…The excellent oncological outcomes reported in our study are consistent with those reported in the international [16][17][18] and Australian literature ( Table 3). [19][20][21][22][23] There is a worldwide trend towards decreased utilisation of PORT for Stage I seminoma. Data from the US National Cancer Database showed that the utilisation of PORT for Stage I seminoma dropped from 71% in 2000 to 47% in 2008, with a corresponding rise in the proportion of patients being put on surveillance from 30% in 2000 to 40% in 2008.…”

Section: Discussionmentioning

confidence: 99%

“…More than half of the patients (59%) had radiation to the PA plus ipsilateral common iliac lymph nodes (the classic [20][21][22][23][24][25][26][27][28]. There was no acute adverse reaction requiring hospital admission following radiation treatment.…”

Section: Treatmentmentioning

confidence: 99%

Long‐term outcomes following post‐operative radiotherapy for Stage I/II testicular seminoma – an Australasian single‐institution experience

Ong

Nazareth

Hindson

et al. 2016

J of Medical Radiation Sci

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IntroductionThe aim of the study is to review the long‐term oncological outcomes and adverse effects of post‐operative radiotherapy (PORT) for Stage I/II seminoma patients in an Australian radiation treatment centre.MethodsThis is a retrospective study of 125 patients with Stage I/II seminoma treated with PORT at the Alfred Health Radiation Oncology Service between 1992 and 2013. Patients were linked to the Victorian Cancer Registry to enable confirmation of survival and diagnosis of secondary malignancies (SM). The relapse‐free survival (RFS), testicular‐cancer‐specific survival (TCSS), overall survival (OS) and SM‐free survival (SMFS) were estimated with Kaplan–Meier methods.ResultsThe median age at diagnosis was 36 (range 20–62). The median time between diagnosis and PORT was 1.6 months (range: 0.5–4.5). Fifty patients (40%) had PORT to the para‐aortic (PA) target alone, while the remaining had PORT to PA and ipsilateral or bilateral iliac lymph nodes. There were no acute adverse effects requiring admission. The median follow‐up after PORT was 7.8 years (range = 0.1–19.1). There were two relapses, both of which occurred within 1 year of PORT (estimated 10‐year RFS = 98.4%). Five deaths were reported, none of which were testicular cancer‐related death (estimated 10‐year TCSS = 100%, 10‐year OS = 97.3%). There were seven SM (one lower lip cancer, one upper shoulder melanoma, one mesothelioma, two prostate cancer, one acute myeloid leukaemia and one contralateral testicular seminoma) reported in six patients, with estimated 10‐year SMFS of 92.9%.ConclusionOur series confirms excellent oncological outcomes among patients with Stage I/II seminoma treated with PORT, with uncommon occurrence of SM.

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Quoi de neuf dans le traitement des séminomes ?

Boujelbene¹,

Ozşahin²,

Khanfir

et al. 2011

Cancer/Radiothérapie

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Is Radiotherapy a Good Adjuvant Strategy for Men With a History of Cryptorchism and Stage I Seminoma?

Cited by 3 publications

References 25 publications

Management of undescended testes: European Association of Urology/European Society for Paediatric Urology Guidelines

Management of undescended testes: European Association of Urology/European Society for Paediatric Urology Guidelines

Long‐term outcomes following post‐operative radiotherapy for Stage I/II testicular seminoma – an Australasian single‐institution experience

Quoi de neuf dans le traitement des séminomes ?

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