Is QT interval prolongation a strong or weak predictor for cardiac death?

Ahnve, Staffan

doi:10.1161/01.cir.84.4.1862

Cited by 32 publications

(14 citation statements)

References 56 publications

(15 reference statements)

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“…[42]. Moreover, as the use of Bazett's formula [24] to calculate QT c has been questioned before [8,26,43], possible differences in effect were taken into account by performing sensitivity analyses using the formulas suggested by Fridericia [25] and by Sagie [26]. In contrast to earlier reports [8], inclusion of different calculations of QT c did not substantially alter our results ( Table 2).…”

Section: Qtc Intervalmentioning

confidence: 63%

QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up

et al. 2006

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Aims/hypothesis We evaluated the association of QT interval corrected for heart rate (QT c ) and resting heart rate (rHR) with mortality (all-causes, cardiovascular, cardiac, and ischaemic heart disease) in subjects with type 1 and type 2 diabetes. Methods We followed 523 diabetic patients (221 with type 1 diabetes, 302 with type 2 diabetes) who were recruited between 1974 and 1977 in Switzerland for the WHO Multinational Study of Vascular Disease in Diabetes. Duration of follow-up was 22.6±0.6 years. Causes of death were obtained from death certificates, hospital records, post-mortem reports, and additional information given by treating physicians.

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Section: Qtc Intervalmentioning

confidence: 63%

QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up

et al. 2006

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“…This may have clinical importance, as in many disease states QTc interval Key words : arrhythmia, heart failure, posture, QT interval. prolongation is a risk factor for ventricular arrhythmias [4,5], and strategies may be developed to shorten QT interval in order to prevent sudden cardiac death. If nocturnal QT interval lengthening is due to posture change rather than to the circadian rhythm, different strategies will be needed.…”

Section: Introductionmentioning

confidence: 99%

Influence of posture and handgrip on the QT interval in left ventricular hypertrophy and in chronic heart failure

Davey

1999

Clinical Science

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In certain disease states prolongation of the QT interval has been shown to be arrhythmogenic. Whether QTc interval changes with position and thus whether certain positions are more arrhythmogenic than others is not known for different diseases that predispose to arrhythmias, and was therefore studied. Patients with left ventricular hypertrophy and heart failure, and the appropriate matched controls, were recruited. Subjects were studied in the lying, sitting, standing and squatting positions and had QT intervals determined by computer algorithm 2 min after each position change. After resting, QT interval was determined while the subjects performed maximum handgrip exercise with their dominant hand. QT intervals were rate-corrected using Bazett's method. QTc interval is prolonged in heart failure patients compared with either left ventricular hypertrophy or control subjects in the lying and sitting position, but not in the standing or squatting position. The QTc intervals for heart failure and control subjects were, respectively, 443+/-7 ms versus 421+/-6 ms when lying (P<0.05), 451+/-10 ms versus 419+/-6 ms when sitting (P<0.05), 429+/-10 versus 414+/-7 ms when standing (P not significant) and 437+/-10 versus 419+/-8 ms when squatting (P not significant). The values for patients with hypertrophy did not differ from control values. Maximum handgrip does not affect the QTc interval in heart failure, but prolongs it in both the hypertrophy and control groups. Position and static exercise are important modifiers of QTc interval and their effect depends on the condition of the left ventricle.

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“…However, it was demonstrated in other studies [22,[35][36][37] that QTc prolongation and increased QTc dispersion is an important factor for predicting risk of sudden cardiac death.…”

Section: Discussionmentioning

confidence: 95%

Prevalence of QTc interval changes in acute psychiatric care: A cross-sectional study

Beyraghi

Rajabi

Hajsheikholeslami

2013

International Journal of Psychiatry in Clinical Practice

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Is QT interval prolongation a strong or weak predictor for cardiac death?

Cited by 32 publications

References 56 publications

QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up

QTc interval and resting heart rate as long-term predictors of mortality in type 1 and type 2 diabetes mellitus: a 23-year follow-up

Influence of posture and handgrip on the QT interval in left ventricular hypertrophy and in chronic heart failure

Prevalence of QTc interval changes in acute psychiatric care: A cross-sectional study

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