Is QT Interval a Marker of Subclinical Atherosclerosis in Nondiabetic Subjects?

Festa, Andreas; D’Agostino, Ralph B.; Rautaharju, Pentti M.; O’Leary, Daniel H.; Rewers, Marian; Mykkänen, Leena; Haffner, Steven M.

doi:10.1161/01.str.30.8.1566

Cited by 76 publications

(48 citation statements)

References 54 publications

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“…30 In women aged 52-88 years with normal fasting glucose, QTc was prolonged as a function of progressive worsening of glucose tolerance. 31 In male subjects, we found a direct relationship between QTc duration and systolic blood pressure; this association, which has been reported in diabetic patients 7 and in middle-aged healthy subjects, 16,32 may depend on an increased sympathetic activity, responsible for both a higher blood pressure 33 and a prolonged QT interval. 34 The gender difference we found in the relationship between QTc duration, glycaemia, and blood pressure may be related to sex differences in cardiac myocyte membrane action potentials.…”

Section: Discussionsupporting

confidence: 70%

“…7 In nondiabetic subjects, the relationship between QTc and carotid atherosclerosis is stronger in women that men. 32 In the present study, we did not find any association between QT dispersion and cardiovascular risk factors. This finding was not unexpected, since QT dispersion measurement suffers from several methodological problems, in particular reproducibility and stability, and is considered an imprecise measurement of repolarization abnormalities.…”

Section: Discussioncontrasting

confidence: 64%

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Relationship between QT interval and cardiovascular risk factors in healthy young subjects

et al. 2005

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A prolongation of QT interval increases the risk for coronary heart disease, ventricular arrhythmias, and sudden death in diabetic patients, after myocardial infarction, and in the elderly. An association between QT prolongation and cardiovascular risk factors has been demonstrated in middle-aged and elderly subjects. Aims of this study were to evaluate the prevalence of a prolonged corrected QT interval (QTc) in a healthy young population (n ¼ 170, age 22-25 years, 84 males) and to investigate the association of QTc and QT dispersion (QTd) with cardiovascular risk factors (body mass index, blood pressure, fasting blood glucose and cholesterol, smoking habits, and hypertensive familiarity). A prolonged QTc was observed in 10% of female and 5% of male subjects; in multiple regression analysis, QTc showed a significant positive relationship with blood glucose in females (P ¼ 0.04) and systolic blood pressure in male subjects (P ¼ 0.03), while QTd was not significantly related with any of the factors.In conclusion, the association between QTc length, glucose levels, and blood pressure is present also in young healthy subjects. QT measurement may represent a useful marker in the screening of young subjects for cardiovascular prevention.

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Section: Discussionsupporting

confidence: 70%

Section: Discussioncontrasting

confidence: 64%

Relationship between QT interval and cardiovascular risk factors in healthy young subjects

et al. 2005

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“…23 QT interval has also been shown to be associated with subclinical arterial disease. [24][25][26] Thus, QT interval prolongation, as a marker of ventricular hypertrophy or subclinical arterial disease, may predict future CVD events.…”

Section: Discussionmentioning

confidence: 99%

QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population: the Hisayama study

et al. 2010

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Uncertainty remains regarding the value of heart-rate-corrected QT interval (QTc) prolongation on electrocardiogram for predicting cardiovascular disease (CVD), particularly among Asian populations. The objective of the present analysis was to analyze the association of QTc prolongation with the development of CVD in a general Japanese population. During the follow-up period, 303 CVD events were observed. Among men, the age-adjusted incidence rates of CVD rose with prolonged QTc levels: 10.9, 12.1, 14.1 and 37.8 per 1000 person-years for subgroups defined by QTc levels of o400, 400-419, 420-439 and X440 ms, respectively (P¼0.0007 for trend). The risk of CVD in the highest group was 3.09-fold (95% confidence interval, 1.82-5.25) higher than that in the lowest group even after controlling for other confounding factors: age, hypertension, heart rate, electrocardiogram abnormalities, diabetes, impaired glucose tolerance, impaired fasting glycemia, body mass index, total and high-density lipoprotein cholesterols, alcohol intake, smoking habit and regular exercise. Similar associations were observed for the outcomes of stroke and coronary heart disease. Among women, in contrast, no clear associations were found between QTc levels and the risk of CVD events. In conclusion, prolonged QTc levels were associated with the development of CVD among general Japanese men. Measurement of QTc intervals is likely to provide additional information for the detection of individuals at high risk of future CVD events.

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“…The HR was previously shown to correlate with IMT in experimental (69,70) and clinical (71) studies. A strong relationship between HR-corrected QT interval and IMT was found in humans with early atherosclerotic disease (71). Despite HR differences between mice and humans, it was shown in humans in vivo that HR increases in physiological ranges were associated with a reduction in arterial compliance (72).…”

Section: Relevance To Human Diseasementioning

confidence: 99%