Is prostacyclin the major pro-inflammatory prostanoid in joint fluid?

Brodie, M.J.; Hensby, C.N.; Parke, Ann L.; Gordon, Duncan A.

doi:10.1016/0024-3205(80)90310-0

Cited by 87 publications

(55 citation statements)

References 10 publications

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“…These data reveal that therapeutic levels of NSAIDs increase the expression of TNF in response to a number of TLR ligands. PGE 2 reverses the effect of NSAIDs on TNF production PGE 2 is one of the most abundant PGs in the RA synovium and is produced as a direct result of COX activity (26). Accordingly, all NSAIDs used in this study effectively reduce PGE 2 production in RA synovial cell membrane cultures (Fig.…”

Section: Nsaid Induced Changes In Tnf Are Seen In Response To a Variementioning

confidence: 67%

Nonsteroidal Anti-Inflammatory Drugs Increase TNF Production in Rheumatoid Synovial Membrane Cultures and Whole Blood

Page

Turner

Brown

et al. 2010

The Journal of Immunology

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Section: Nsaid Induced Changes In Tnf Are Seen In Response To a Variementioning

confidence: 67%

Nonsteroidal Anti-Inflammatory Drugs Increase TNF Production in Rheumatoid Synovial Membrane Cultures and Whole Blood

Page

Turner

Brown

et al. 2010

The Journal of Immunology

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“…These products have been detected in carrageenin-induced inflammation (Higgs & Salmon, 1979) and chronic joint inflammation in man (Brodie, Hensby, Parke & Gordon, 1980;Bombardieri, Cattani, Ciabattoni, Di Munno, Pasero, Patrono, Pinca & Pugliese, 1981) but it is not clear from which tissues they are derived. Thromboxane A2 (TXA2) is the major cyclo-oxygenase product in platelets (Hamberg, Svensson & Samuelsson, 1975) and circulating leukocytes (Morley, Bray, Jones, Nugteren & Van Dorp, 1979) whereas vascular endothelial cells produce mainly prostacyclin (Moncada, Gryglewski, Bunting & Vane, 1976).…”

Section: Introductionmentioning

confidence: 99%

The source of thromboxane and prostaglandins in experimental inflammation

Higgs

Moncada

Salmon

et al. 1983

British J Pharmacology

115

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1Although cyclo-oxygenase products have been detected at inflammatory sites the tissue of origin remains uncertain. 2 Inflammatory exudates were collected from rats 4, 6, 8, 12 or 24 h after subcutaneous implantation of carrageenin-impregnated sponges.3 Concentrations of the cyclo-oxygenase products prostaglandin E2 (PGE2), 6-oxo-PGF,,, and thromboxane B2 (TXB2) in inflammatory exudates and serum (obtained from blood clotted at 370 C) were measured by specific radioimmunoassays. 4 TXB2 concentrations in exudates increased to about 100 ng ml-l at 8 h but decreased to less than 20 ng ml-l after 24 h. PGE2 concentrations increased from 4-12 h and remained between 80 and 120 ng ml 'from 12 -24 h. 6-oxo-PGF,,, had the same time course as that of PGE2 but concentrations were approximately one third of PGE2 values. 5 TXB2 concentrations in serum from thrombocytopaenic rats were less than 5 % of control values.Thrombocytopaenia did not affect TXB2, PGE2 or 6-oxo-PGFI,e concentrations or total leukocyte numbers in inflammatory exudates. 6 Methotrexate-induced neutropaenia did not affect serum TXB2 concentrations but cyclooxygenase products (including TXB2) in 6 h inflammatory exudates were reduced by 60-95 %. 7 Colchicine (1.0 mg kg-' s.c.) prevented leukocyte accumulation in sponge exudates and this was accompanied by a reduction in TXB2, PGE2 and 6-oxo-PGFI, concentrations at 6 h.8 These results indicate that platelets are the source of TXB2 in clotting blood but do not contribute to cyclo-oxygenase activity in experimental inflammation. The results also suggest that migrating leukocytes are the major source of thromboxane and to a lesser degree prostaglandins in acute 6 h inflammatory exudates.

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“…The reaction of N,N-dimethyl hydrazine allowed for the product 24 in 63% yield. This approach allowed us to use cyclic pyrazolinone derivatives such as hexahydropyridazine and [1, 3,5]oxadiazepane.…”

Section: Tandem 14-addition-cyclization Reaction Of 1 With Hydrazinementioning

confidence: 99%

3,3-Dibromo-2-trifluoromethyl acrylic acid ethyl ester: a versatile platform for the stereoselective preparation of functionalized-α-trifluoromethyl α,β-unsaturated lactones and trifluoromethyl pyrazolinones

et al. 2016

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We herein describe a method for the synthetic routes to multi-functionalized-α-trifluoromethyl α,β-unsaturated lactones and trifluoromethyl pyrazolinones. This involves tandem stereoselective functionalization of 3,3-dibromo-2-trifluoromethyl acrylic acid ethyl ester and intramolecular cyclization reaction to afford precursors for a Suzuki-Miyaura cross-coupling reaction with arylboronic acids.

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Is prostacyclin the major pro-inflammatory prostanoid in joint fluid?

Cited by 87 publications

References 10 publications

Nonsteroidal Anti-Inflammatory Drugs Increase TNF Production in Rheumatoid Synovial Membrane Cultures and Whole Blood

Nonsteroidal Anti-Inflammatory Drugs Increase TNF Production in Rheumatoid Synovial Membrane Cultures and Whole Blood

The source of thromboxane and prostaglandins in experimental inflammation

3,3-Dibromo-2-trifluoromethyl acrylic acid ethyl ester: a versatile platform for the stereoselective preparation of functionalized-α-trifluoromethyl α,β-unsaturated lactones and trifluoromethyl pyrazolinones

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