Is Prophylactic Antibiotic Therapy Needed in Thyroidectomy?

Rao, Vinay V; Dsouza, Caren

doi:10.1007/s12070-021-02393-3

Cited by 3 publications

(13 citation statements)

References 13 publications

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“…After exclusion of duplicates, we screened 760 references and identified 18 eligible references; from these, nine were excluded as not meeting inclusion criteria or not providing data on the outcome of interest [12,[16][17][18][19][20][21][22][23]. The remaining nine studies presenting quantitative data were included in the meta-analysis [11,[13][14][15][24][25][26][27][28].…”

Section: Literature Search and Selection Of Studiesmentioning

confidence: 99%

“…Characteristics of the included studies are presented in Table 1. Four studies were RCTs [14,24,27,28] and five nRCTs [13,15,25,26], published between 2013 and 2021. Two studies were multicentric [11,13], involving 27 and 38 departments of surgery, respectively, while the remaining studies provided data from a single center [13,14,[24][25][26][27][28].…”

Section: Characteristics Of Interventions and Populations In The Incl...mentioning

confidence: 99%

“…Four studies were RCTs [14,24,27,28] and five nRCTs [13,15,25,26], published between 2013 and 2021. Two studies were multicentric [11,13], involving 27 and 38 departments of surgery, respectively, while the remaining studies provided data from a single center [13,14,[24][25][26][27][28]. The included studies involved 8710 participants (a range of 53 to 2926 per study) from eight countries (Greece, Korea, India, Israel, Italy, Japan, the US and Sweden) in three continents (Europe, Asia and America).…”

Section: Characteristics Of Interventions and Populations In The Incl...mentioning

confidence: 99%

“…The mean age ranged from 43.11 to 60.6 years, while the highest prevalence of male sex was 26.6%. Similar inclusion criteria across studies were clean neck surgery for thyroid [11,14,15,25,28] or thyroid and parathyroid diseases [24,26,27,29]. Five studies included only thyroidectomies, while four also included parathyroidectomies; in one study [27] two parotidectomies were also included (3.7%, one per each group).…”

Section: Characteristics Of Interventions and Populations In The Incl...mentioning

confidence: 99%

“…Owing to the availability of new studies published on the subject [13][14][15], we conducted a systematic review of the most recent evidence with the aim to guide clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis

et al. 2022

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Thyroid and parathyroid surgery are considered clean procedures, with an incidence of surgical site infection (SSI) after thyroidectomy ranging from 0.09% to 2.9%. International guidelines do not recommend routine antibiotic prophylaxis (AP), while AP seems to be employed commonly in clinical practice. The purpose of this systematic review is analyzing whether the postoperative SSI rate in thyroid and parathyroid surgery is altered by the practice of AP. We searched Pubmed, Scopus, the Cochrane Library, and Web of Science (WOS) for studies comparing AP to no preoperative antibiotics up to October 2021. Data on the SSI rate was evaluated and summarized as relative risks (RR) with 95% confidence intervals (95% CI). Risk of bias of studies were assessed with standard methods. Nine studies (4 RCTs and 5 nRCTs), including 8710 participants, were eligible for quantitative analysis. A meta-analysis showed that the SSI rate was not significantly different between AP and no preoperative antibiotics (SSI rate: 0.6% in AP vs. 2.4% in control group; RR 0.69, 0.43–1.10 95% CI, p = 0.13, I2 = 0%). A sensitivity analysis and subgroup analysis on RCTs were consistent with the main findings. Evidence of low quality supports that AP in thyroid and parathyroid surgery produce similar SSI rates as to the absence of perioperative antibiotics.

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Section: Literature Search and Selection Of Studiesmentioning

confidence: 99%

Section: Characteristics Of Interventions and Populations In The Incl...mentioning

confidence: 99%

Section: Characteristics Of Interventions and Populations In The Incl...mentioning

confidence: 99%

Section: Characteristics Of Interventions and Populations In The Incl...mentioning

confidence: 99%

“…Owing to the availability of new studies published on the subject [13][14][15], we conducted a systematic review of the most recent evidence with the aim to guide clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis

et al. 2022

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Benefits and Risks Associated With Antibiotic Prophylaxis for Thyroid Operations

Squires,

Cisco,

Lin

et al. 2024

Journal of Surgical Research

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Appropriateness of perioperative antibiotics in thyroid surgery

Yadav

Dangol

Shrestha

et al. 2023

J Patan Acad Health Sci

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Introduction: Most of the guidelines do not recommend routine antibiotics prophylaxis in clean head and neck surgery like thyroidectomy. In contrary to the recommendation, antibiotics are being routinely prescribed in perioperative period for various duration in many centers of Nepal. This study was aimed to find out the need of postoperative antibiotics in surgeries for thyroid related problems. Method: Records of all patients who had undergone surgery for thyroid related problems from Jan, 2019 to Sept, 2022 were retrospectively reviewed for patterns of antibiotic use, apart from preincision antibiotic, in postoperative period which was classified as group A – no antibiotics, group B – shorter course of antibiotics (≤3 days) and group C – longer course of antibiotics (>3 days). The occurrence of surgical site infection (SSI) was recorded. Result: During the study period, 77 patients underwent surgery for thyroid related problems, out of which five were excluded (records not found in four cases and one patient was ASA III). Two out of 72 (2.77 %) patients developed superficial incisional SSI which was managed conservatively. One patient in each group A (50) and group B (8) developed SSI. Conclusion: Postoperative antibiotics can be avoided safely even in our setup in clean head and neck surgeries like thyroidectomy without increase in the risk of SSI thus reducing the cost to the patients.

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Is Prophylactic Antibiotic Therapy Needed in Thyroidectomy?

Cited by 3 publications

References 13 publications

Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis

Effect of Antibiotic Prophylaxis on Surgical Site Infection in Thyroid and Parathyroid Surgery: A Systematic Review and Meta-Analysis

Benefits and Risks Associated With Antibiotic Prophylaxis for Thyroid Operations

Appropriateness of perioperative antibiotics in thyroid surgery

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