Is prophylactic administration of the anticonvulsants necessary in tramadol-intoxicated patients after an initial seizure?

Sanaei‐Zadeh, Hossein

doi:10.1186/2008-2231-21-60

Cited by 4 publications

(2 citation statements)

References 14 publications

(16 reference statements)

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“…Among them, 11 patients consented to give at least two blood samples. Exclusion criteria were met and the treatment of patients [ 14 , 15 ] was not influenced by the process of data collecting. Ethics approval was obtained from ethics committee of the Mashhad University of Medical Sciences (MUMS/89/1876).…”

Section: Resultsmentioning

confidence: 99%

Tramadol half life is dose dependent in overdose

et al. 2015

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BackgroundTramalol overdose is disproportionately more common in Iran. In recent years, Tramadol overdose has become one of the most common causes of poisoning admissions to emergency departments in this country. To the best of our knowledge, there is little or no information regarding the toxicokinetic properties of Tramadol such as its half life. Given the fact that poisoning management should be based on the toxicokinetic of substances, we aimed at investigating the half life of Tramadol in man as a critical toxicokinetic variable in overdose.MethodsBlood samples of each patient were collected on admission and repeated later. Plasma was harvested after separation from blood cells by centrifugation and quantified using HPLC method. Calculations were performed on Tramadol blood concentration quantities.FindingsDemographic: Most of cases were men (81.81%). Mean (Standard Deviation (SD), min-max) age was 23 (8.142, 17-40). Serum Tramadol levels: Mean (SD, min-max) first Tramadol concentration was 786.91 (394.53, 391-1495). Mean (SD, min-max) second Tramadol concentration was 433.09 (269.63, 148-950). Mean (SD, min-max) of Tramadol half life was calculated as 9.24 hour (2.310, 4.99-13.45) Associations: Half life was associated with higher concentrations (r=0.708 Sig=0.015).ConclusionWe report the mean half life of tramadol in overdose to be 9.24 hours which is remarkably higher than that measured in previous pharmacokinetic studies. We also concluded that Tramadol half life is dose dependent in overdose which may explain the further consequences of severe overdoses.

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Section: Resultsmentioning

confidence: 99%

Tramadol half life is dose dependent in overdose

et al. 2015

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“…Brain CT was normal in all and magnetic resonance imaging (MRI) was normal in five patients [77]. Tramadol-induced seizure can cause trauma, intra-articular dislocation, and tongue laceration [67,81,82].…”

Section: Cns Manifestations Of Tramadol Toxicitymentioning

confidence: 99%