Is prolactin a gonadotrophic hormone in red deer (Cervus elaphus)? Pattern of expression of the prolactin receptor gene in the testis and epididymis

Jabbour, HN; Clarke, Luka A.; McNeilly, A. S.; Edery, Marc; Kelly, P. A.

doi:10.1677/jme.0.0200175

Cited by 14 publications

(12 citation statements)

References 26 publications

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“…PRLR expression has been reported in a wide variety of cells and tissues. In male, PRLR was expressed in the testes and in various male accessory glands include vas deferens, epididymis, prostates and seminal vesicles 11 13 31 , which demonstrated that these organs might be direct targets of PRL, suggesting multiple regulatory roles for PRL in male reproductive tract. The present study demonstrated for the first time the expression of the PRLR gene and protein in the scented glands of the male muskrats during the breeding and nonbreeding seasons.…”

Section: Discussionmentioning

confidence: 96%

Seasonal Expression of Prolactin Receptor in the Scented Gland of Male Muskrat (Ondatra zibethicus)

Cao

Wang

Zhang

et al. 2015

Sci Rep

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Prolactin (PRL) has numerous actions in mammalian biological systems including mammary development and biological processes. The aim of this study was to investigate the seasonal changes of prolactin receptor (PRLR) expression in the scented gland of muskrat during the breeding and nonbreeding seasons. Histologically, glandular cells, interstitial cells and excretory tubules were identified in the scented glands in both seasons, whereas epithelial cells were sparse in the nonbreeding season. PRLR was observed in glandular cells of scented glands during the breeding and nonbreeding seasons with stronger immunostaining during the breeding season. Consistent with the immunohistochemical results, both the mean of protein and mRNA levels of PRLR were higher in the scented glands of the breeding season, and relatively lower level in the nonbreeding season. In addition, differential seasonal changes were also detected in the expression profile of microRNAs (miRNAs) in the scented gland of muskrat. Besides, plasma PRL concentration was remarkably higher in the breeding season than that in the nonbreeding season. These results suggested that muskrat scented gland was the direct target organ of PRL, and stronger expression of PRLR in scented glands during the breeding season indicated that PRL may directly regulate scented glandular function of the muskrats.

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Section: Discussionmentioning

confidence: 96%

Seasonal Expression of Prolactin Receptor in the Scented Gland of Male Muskrat (Ondatra zibethicus)

Cao

Wang

Zhang

et al. 2015

Sci Rep

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“…In a report on bears, prolactin increased the LH receptor expression level in the testis [ 22 ], suggesting that prolactin is also involved in activation of the gonadal function in horses by stimulating LH receptor expression in the gonads and increasing LH sensitivity. The expression of prolactin receptor has been reported in the testes and various male accessory glands [ 18 , 20 , 24 ], indicating that these organs are targets of prolactin in male reproductive organs. Previous studies have also demonstrated the expression of testicular prolactin receptor increased during testicular recrudescence in the breeding season [ 6 , 22 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of an extended photoperiod on gonadal function and condition of hair coats in Thoroughbred colts and fillies

Kunii

Nambo

Okano

et al. 2015

JES

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The effects of an extended photoperiod (EP) in Thoroughbreds colts and fillies from winter at one year old to spring at two years old on the gonadal functions, coat condition, and endocrine changes were investigated. Sixty-two Thoroughbreds (31 colts and 31 fillies) reared in the Hidaka Training and Research Center (Hidaka), Japan Racing Association were used. Thirty of them (15 colts and 15 fillies) were reared under EP conditions from December 20 to April 10, and the remaining 32 horses were reared under natural light alone as a control group. For EP, a 100-watt white bulb was set near the ceilings of stalls, and lighting conditions of 14.5-hr light and 9.5-hr dark periods were established. Blood was collected from the jugular vein once a month from October at one year old to February at two years old in both colts and fillies, and then twice a month in colts and weekly in fillies after March, and the coat condition was evaluated in January and April in 56 horses. To investigate endocrine changes, the plasma concentrations of prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), immunoreactive (ir-) inhibin, testosterone, estradiol-17β and progesterone were measured. No significant difference was noted in the coat condition between the two groups in January, but they changed from winter to summer coats (molting of winter coats) in April in the EP group compared with the control group. Regarding endocrine changes, the plasma concentrations of prolactin, FSH, ir-inhibin and testosterone were significantly higher in the EP colts than in the control group from January to April. The plasma concentrations of LH tended to rise in the EP colts from January to April compared with the control group. In the EP fillies, the plasma concentrations of prolactin, LH, ir-inhibin, estradiol-17β and progesterone were significantly higher during January and April, but a significantly high level of FSH was noted in the control than EP group in January. The ovulation day was advanced in the EP fillies compared with the control group. The present study clearly demonstrated that EP treatment during rearing advanced the molting of winter coats in both colts and fillies. These results suggested to be due to the action of prolactin being increased by EP treatment. In addition, EP treatment stimulated the hypothalamus-pituitary-gonadal axis even in yearlings, and advanced ovulation in fillies. Since EP treatment-induced changes in the yearlings were within the physiological range, and the method is safe and simple, EP treatment may be an effective technique in horse husbandry.

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“…In all species studied, PRL acts by binding to a specific membrane receptor (PRL-R) (Clarke et al 1997;Jabbour et al 1998;Ohkubo et al 1998;Howell-Skalla et al 2000;Sandra et al 2000;Higashimoto et al 2001). Two main forms of PRL-R transcript have been identified (BoleFeysot et al 1998), one of which is specific for a short form of receptor (Boutin et al 1988), while the other is specific for a long form whose molecule possesses a cytoplasmic tail (Boutin et al 1988;Shirota et al 1990).…”

Section: Introductionmentioning

confidence: 99%

Visualization of gene expression of prolactin-receptor (PRL-R) by in situ hybridization in reproductive organs of Typhlonectes compressicauda, a gymnophionan amphibian

Exbrayat

Morel

2003

Cell and Tissue Research

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The expression of the long form of prolactin receptor (PRL-R) mRNAs was studied in reproductive organs from both male and female Typhlonectes compressicauda, an amphibian, by quantitative in situ hybridization. These PRL-R mRNAs were expressed in all the organs studied. In ovarian tissue, mRNAs coding for the long form of PRL-R were strongly expressed in ovaries with compact and vascularized corpora lutea, i.e., during the middle and the end of pregnancy. During the other periods of cycle, sexual rest, vitellogenesis and beginning of pregnancy, expression of these mRNAs was lower than in other periods. In the testis, mRNAs coding for the long form of PRL-R were expressed in germ cells as well as in Leydig and Sertoli cells. In müllerian glands, important variations of expression in these mRNAs have been observed with a large increase during the breeding period and a decrease during sexual rest. Variations of gene expression of the long form of PRL-R for all tissues studied are correlated to synthesis of PRL in the pituitary in both male and female Typhlonectes compressicauda.

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Is prolactin a gonadotrophic hormone in red deer (Cervus elaphus)? Pattern of expression of the prolactin receptor gene in the testis and epididymis

Cited by 14 publications

References 26 publications

Seasonal Expression of Prolactin Receptor in the Scented Gland of Male Muskrat (Ondatra zibethicus)

Seasonal Expression of Prolactin Receptor in the Scented Gland of Male Muskrat (Ondatra zibethicus)

Effects of an extended photoperiod on gonadal function and condition of hair coats in Thoroughbred colts and fillies

Visualization of gene expression of prolactin-receptor (PRL-R) by in situ hybridization in reproductive organs of Typhlonectes compressicauda, a gymnophionan amphibian

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