Is procalcitonin a reliable marker for the diagnosis of infected pancreatic necrosis?

Yönetçi, Nadir; Sungurtekin, Uğur; Oruç, Nevin; Yılmaz, Mustafa; Sungurtekin, Hülya; Kaleli, İlknur; Kaptanoǧlu, Bünyamin; Yüce, Gül; Özütemiz, Ömer

doi:10.1111/j.1445-2197.2004.03059.x

Cited by 13 publications

(10 citation statements)

References 29 publications

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“…Endotoxins can cause serious organ damage and death by triggering activation of inflammatory cells (11) and a sequence of events including blood vessel dilation, increased blood flow, and leukocyte infiltration (12). Massive accumulation of neutrophils, interstitial pulmonary edema, and increased expression of proinflammatory mediators are the major characteristics of acute pulmonary injury (13).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of β-glucan on acute lung injury induced bylipopolysaccharide in rats

Iraz¹,

Eşrefoğlu²,

Aydın³

2015

Turk J Med Sci

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Background/aim: Lipopolysaccharide (LPS)-induced endotoxemia can cause serious organ damage such as acute lung injury and death by triggering the secretion of proinflammatory cytokines and acute-phase reactants. The goal of this study was to evaluate the effects of β-glucan on inflammatory mediator levels and histopathological changes in LPS-induced endotoxemia. Materials and methods:Forty-seven male Wistar albino rats were randomly allocated into four groups as follows: control group, LPS group (10 mg/kg LPS), LPS + β-glucan group (100 mg/kg β-glucan before LPS administration), and β-glucan group. Twelve hours after LPS administration, lung and serum samples were collected. Concentrations of IL-6, IL-8, C-reactive protein (CRP), and procalcitonin were measured in the serum at hours 0 (basal) and 12. The severity of lung damage was assessed by an appropriate histopathological scoring system. Results: Serum levels of CRP in the LPS group at 12 h were significantly higher than in the other groups, whereas serum IL-6 levels in the LPS and LPS + β-glucan groups at 12 h were significantly decreased. The mean histopathological damage score of the LPS group was slightly higher than that of the LPS + β-glucan group. Moreover, mortality rate was significantly decreased in the LPS + β-glucan group versus the LPS group.Conclusion: β-Glucan reduces endotoxemia-induced mortality and might be protective against endotoxemia-induced lung damage.

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Section: Discussionmentioning

confidence: 99%

Protective effect of β-glucan on acute lung injury induced bylipopolysaccharide in rats

Iraz¹,

Eşrefoğlu²,

Aydın³

2015

Turk J Med Sci

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“…Cerulein is a cholecystokinin analogue that relaxes the sphincter of Oddi and contracts the gallbladder with resulting bile reflux into the pancreatic canal and pancreatitis [10] . Intraperitoneal, intravenous and subcutaneous cerulein have been used in experimental models of pancreatitis [11,12] .…”

Section: Discussionmentioning

confidence: 99%

Effect of Mycophenolate Mofetil on Cerulein-Induced Acute Pancreatitis

Taşdoğan¹,

Kucuk²,

Kurt³

et al. 2010

Eur Surg Res

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Aim: The aim of this study was to determine the effects of mycophenolate mofetil (MMF) on acute pancreatitis with evaluation of biochemical and histopathological findings. Materials and Methods: Cerulein was administered to induce acute pancreatitis in rats. Three groups of 10 rats each were formed. Animals in group 1 received physiologic saline solution. In group 2 animals received MMF at a dose of 14 mg/kg and group 3 had double doses of MMF. Alanine aminostransferase, aspartate aminotransferase (AST), amylase and bilirubin levels were assessed. Pancreatic tissues were evaluated under light microscopy for the presence of edema, acinar necrosis, hemorrhage, inflammation and perivascular infiltration. Results: Amylase, serum AST, edema and inflammatory infiltration levels differed between groups (amylase: p = 0.0001, serum AST: p = 0.001, edema: p = 0.0001 and inflammatory infiltration: p = 0.002), group 1 showing the highest amylase, serum AST and edema levels. The lowest levels of edema were found in group 3. Conclusion: In an experimental pancreatitis model in rats, MMF proved to exert a beneficial effect on biochemical and histopathological parameters.

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“…[8,9] Cerulein is widely used in experimental models of AP. [10,11] Intraperitoneal, intravenous and subcutaneous administration of cerulein leads to edematous pancreatitis and necrotizing pancreatitis, which are characterized by edema and increased levels of serum amylase, as well as by acinar cell vacuolization and leukocyte infiltration histologically, through the stimulation of cholecystokinin receptors within the pancreatic tissue. [12,13] The aim of the present study was to determine the effects of ALA, which has anti-oxidative and antiinflammatory properties, on blood and tissue biochemical parameters as well as tissue histopathology in an experimental rat model of cerulein-induced AP.…”

Section: Methodsmentioning

confidence: 99%

Beneficial effects of alpha lipoic acid on cerulein-induced experimental acute pancreatitis in rats

Bulut¹,

Özkan²,

Ekinci³

et al. 2011

Ulus Travma Acil Cerrahi Derg

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Is procalcitonin a reliable marker for the diagnosis of infected pancreatic necrosis?

Abstract: Procalcitonin and IL-6 acts as reliable acute phase reactant in an experimental model of AEP, SPN and IPN in the rat. PCT and IL-6 combination might be surrogate marker of infected pancreatic necrosis and should be preferred to other markers assay especially in severe pancreatitis.

Cited by 13 publications

References 29 publications

Protective effect of β-glucan on acute lung injury induced bylipopolysaccharide in rats

Protective effect of β-glucan on acute lung injury induced bylipopolysaccharide in rats

Effect of Mycophenolate Mofetil on Cerulein-Induced Acute Pancreatitis

Beneficial effects of alpha lipoic acid on cerulein-induced experimental acute pancreatitis in rats

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