Is Procalcitonin a Diagnostic and/or Prognostic Marker in Sepsis?

Afşar, İlhan; Şener, Aslı Gamze

doi:10.1097/ipc.0000000000000187

Cited by 13 publications

(26 citation statements)

References 35 publications

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“…PCT appears to be an early marker of SIRS caused by bacterial infections and associated products in human medicine . PCT originates from the CALC‐I gene transcription and calcitonin‐mRNA translation.…”

Section: Discussionmentioning

confidence: 99%

“…The diseases that have been associated with SIRS in adult horses are especially those involving the gastrointestinal tract, such as the inflammatory intestinal diseases and strangulating obstructions . An early diagnosis should be the goal in the management of SIRS patients, allowing starting an adequate treatment in an early stage . Due to the importance of procalcitonin (PCT) as biomarker of SIRS in human medicine, the aim of the present work was to evaluate the plasma PCT concentration in healthy and SIRS horses to evaluate the differences between the two groups.…”

mentioning

confidence: 99%

“…An early diagnosis should be the goal in the management of SIRS patients, allowing starting an adequate treatment in an early stage . Due to the importance of procalcitonin (PCT) as biomarker of SIRS in human medicine, the aim of the present work was to evaluate the plasma PCT concentration in healthy and SIRS horses to evaluate the differences between the two groups.…”

mentioning

confidence: 99%

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Plasma Procalcitonin Concentration in Healthy Horses and Horses Affected by Systemic Inflammatory Response Syndrome

Bonelli

Meucci

Divers

et al. 2015

Veterinary Internal Medicne

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BackgroundThe diseases most frequent associated with SIRS in adult horses are those involving the gastrointestinal tract. An early diagnosis should be the goal in the management of horses with SIRS.ObjectiveThe objective of this study was to evaluate the plasma procalcitonin (PCT) concentration in healthy and SIRS horses to assess differences between the two groups.AnimalsSeventy‐eight horses (30 healthy and 48 SIRS).MethodsProspective in vivo multicentric study. Horses were classified as SIRS if at least 2 of the following criteria were met: abnormal leukocyte count or distribution, hyperthermia or hypothermia, tachycardia, tachypnea. Healthy horses showed no clinical or laboratory signs of SIRS. Plasma PCT concentrations were measured with a commercial ELISA assay for equine species. Results were expressed as mean±standard deviation. T‐test for unpaired data was performed between healthy and SIRS group. SIRS group was divided in 4 subgroups and t‐test was performed between healthy versus each subgroup.Results PCT concentrations in healthy and SIRS horses were 18.28 ± 20.32 and 197.0 ± 117.0 pg/mL, respectively. T‐test showed statistical differences between healthy versus SIRS group and between healthy versus all subgroups.Conclusions and Clinical ImportanceResults showed an increase in PCT concentration in SIRS horses as previously reported in humans and dogs. PCT could be used as a single assay in equine practice for detection of SIRS.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Plasma Procalcitonin Concentration in Healthy Horses and Horses Affected by Systemic Inflammatory Response Syndrome

Bonelli

Meucci

Divers

et al. 2015

Veterinary Internal Medicne

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“…The cut-off value (73.04 pg/mL) is lower compared to findings reported for men, both adults 188 Most recent studies in human medicine on this item evaluated the use of PCT as diagnostic 192 marker to discriminate SIRS of non-infectious origin vs SIRS of infectious [30,31]. 193…”

mentioning

confidence: 87%

“…Moreover, the use of PCT has been recently studied to guide antibiotic therapy in order to 194 shorten antimicrobial treatment [31][32][33] …”

mentioning

confidence: 99%

Evaluation of Plasma Procalcitonin Concentrations in Healthy Foals and Foals Affected by Septic Systemic Inflammatory Response Syndrome

Bonelli

Meucci

Divers

et al. 2015

Journal of Equine Veterinary Science

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Plasma procalcitonin concentration in healthy calves and those with septic systemic inflammatory response syndrome

Bonelli¹,

Meucci²,

Divers

et al. 2018

The Veterinary Journal

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The diagnosis of sepsis in calves is challenging. Blood culture and clinical signs combined with a complete blood count have been used for the diagnosis of sepsis. Recent literature in humans and animal species has been focused on sepsis-specific biomarkers, such as procalcitonin (PCT), that may more accurately and efficiently diagnose sepsis. The aim of this study was to evaluate plasma PCT concentrations in healthy and septic calves. Twenty healthy control calves and 58 sick calves with septic systemic inflammatory response syndrome (SIRS) based on SIRS score and clinical findings were included. Calves with septic SIRS were further divided in septic SIRS survivors (SSS) and non-survivors (SSNS). Plasma PCT concentrations were measured with a commercial ELISA assay for cattle. A receiver operating characteristic curve was used to determine cut-off values and corresponding sensitivity and specificity for the diagnosis of sepsis. Differences in plasma PCT concentration between groups (control vs. SSS vs. SSNS) were evaluated. Plasma PCT concentrations in healthy calves and those with septic SIRS were 33.3pg/mL (0-44.3pg/mL) and 166.5pg/mL (85.9-233.0pg/mL), respectively (P<0.001). The optimal cut-off value to predict septic SIRS was 67.39pg/mL (81.0% sensitivity, 95.0% specificity). Plasma PCT concentrations were 127.4pg/mL (72.2-216.0pg/mL) and 234.3pg/mL (204.5-309.4pg/mL) in the SSS and SSNS subgroups, respectively. Statistically significant differences were found among groups (control vs. SSS and SSNS, P<0.0001; SSS vs. SSNS, P>0.05). These results confirmed an increase in plasma PCT concentrations in calves with septic SIRS, as previously reported in humans and other species.

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Is Procalcitonin a Diagnostic and/or Prognostic Marker in Sepsis?

Cited by 13 publications

References 35 publications

Plasma Procalcitonin Concentration in Healthy Horses and Horses Affected by Systemic Inflammatory Response Syndrome

Plasma Procalcitonin Concentration in Healthy Horses and Horses Affected by Systemic Inflammatory Response Syndrome

Evaluation of Plasma Procalcitonin Concentrations in Healthy Foals and Foals Affected by Septic Systemic Inflammatory Response Syndrome

Plasma procalcitonin concentration in healthy calves and those with septic systemic inflammatory response syndrome

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