Is Presence of Interferon Predictive for Aids?

Buimovici‐Klein, Elena; Lange, Michael; Klein, Richardj .; Cooper, Louis Z.; Grieco, MichaelH.

doi:10.1016/s0140-6736(83)90322-7

Cited by 48 publications

(14 citation statements)

References 5 publications

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“…HIV-1 infection in hu-mice resulted in sustained plasma viremia ( Figure 1A). Similar to clinical observations (4,27), HIV-1 infection in hu-mice also led to induction of IFN-Is including IFN-α and IFN-β ( Figure 1B) and the induction of ISGs, including Mx2, IFITM3, Trim22, ISG15, OAS1, MxA, and IFN regulatory factor 7 (IRF7) both in peripheral blood mononuclear cells (PBMCs) ( Figure 1C) and in the spleen ( Figure 1D). …”

Section: Persistent Hiv-1 Infection Leads To Sustained and Systemic Isupporting

confidence: 81%

Type I interferons suppress viral replication but contribute to T cell depletion and dysfunction during chronic HIV-1 infection

Liu¹,

Yu²,

Li³

et al. 2017

JCI Insight

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Section: Persistent Hiv-1 Infection Leads To Sustained and Systemic Isupporting

confidence: 81%

Type I interferons suppress viral replication but contribute to T cell depletion and dysfunction during chronic HIV-1 infection

Liu¹,

Yu²,

Li³

et al. 2017

JCI Insight

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“…Human pDC are rapidly activated by HIV-1 infection [41] and the level of pDC activation is reversely correlated with CD4 + T-cell numbers [41], which is consistent with the observation from HIV-1 infected patients [15], [20], [21] and SIV infected monkeys [16], [23]. To define the role of human pDC in HIV-1 replication and immunopathogenesis in vivo, we developed a monoclonal antibody that specifically and efficiently depletes human pDC in all lymphoid organs in humanized mice in vivo.…”

Section: Introductionsupporting

confidence: 86%

“…Persistent activation of pDC and IFN-I have been correlated with HIV-1 infection induced immune activation both in HIV-infected patients and in SIV-infected rhesus monkeys [15], [20], [21],[16], [18], [23], [49], [50], [51]. The role of pDC in HIV-1 infection and immunopathogenesis, however, remains unclear [52], [53], [54].…”

Section: Discussionmentioning

confidence: 99%

“…Sustained IFN-I production is correlated with HIV-1 induced immune activation and disease progression both in HIV-1 infected patients [15] and pathogenic SIV infected monkey models [16], [17], [18]. Although IFN-I inhibits HIV-1 replication in vitro [19], the high level IFN-I in HIV-1 patients is not correlated with viral control but is predictive of HIV-1 disease progression [20], [21]. IFN-I is induced during acute phase of SIV infection in both pathogenic and non-pathogenic hosts.…”

Section: Introductionmentioning

confidence: 99%

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Plasmacytoid Dendritic Cells Suppress HIV-1 Replication but Contribute to HIV-1 Induced Immunopathogenesis in Humanized Mice

et al. 2014

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The role of plasmacytoid dendritic cells (pDC) in human immunodeficiency virus type 1 (HIV-1) infection and pathogenesis remains unclear. HIV-1 infection in the humanized mouse model leads to persistent HIV-1 infection and immunopathogenesis, including type I interferons (IFN-I) induction, immune-activation and depletion of human leukocytes, including CD4 T cells. We developed a monoclonal antibody that specifically depletes human pDC in all lymphoid organs in humanized mice. When pDC were depleted prior to HIV-1 infection, the induction of IFN-I and interferon-stimulated genes (ISGs) were abolished during acute HIV-1 infection with either a highly pathogenic CCR5/CXCR4-dual tropic HIV-1 or a standard CCR5-tropic HIV-1 isolate. Consistent with the anti-viral role of IFN-I, HIV-1 replication was significantly up-regulated in pDC-depleted mice. Interestingly, the cell death induced by the highly pathogenic HIV-1 isolate was severely reduced in pDC-depleted mice. During chronic HIV-1 infection, depletion of pDC also severely reduced the induction of IFN-I and ISGs, associated with elevated HIV-1 replication. Surprisingly, HIV-1 induced depletion of human immune cells including T cells in lymphoid organs, but not the blood, was reduced in spite of the increased viral replication. The increased cell number in lymphoid organs was associated with a reduced level of HIV-induced cell death in human leukocytes including CD4 T cells. We conclude that pDC play opposing roles in suppressing HIV-1 replication and in promoting HIV-1 induced immunopathogenesis. These findings suggest that pDC-depletion and IFN-I blockade will provide novel strategies for treating those HIV-1 immune non-responsive patients with persistent immune activation despite effective anti-retrovirus treatment.

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“…Il est particulièrement intéressant de noter que la découverte d 'un taux sérique élevé d 'interféron endo gène chez des patients atteints du syndrome d'immu nodéficience acquise et porteurs d 'un sarcome de Kaposi évolutif signe un pronostic fort sombre et contre-indique en pratique le recours à l'interféron exogène [1,4,7,9,25]. Ces dosages n'ont malheureuse ment pas été réalisés dans le sarcome de Kaposi médi terranéen où ils devraient revêtir une signification identique.…”

Section: Etude De Casunclassified

Sarcome de Kaposi: traitement par facteur de transfert et interféron-alpha-2

Bourlond¹,

Dubois²,

Deselys³

1987

Dermatology

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Immunotherapy with interferon and transfer factor has been tried in 2 cases of Kaposi’s sarcoma of the Mediterranean type, without visceral involvement. Clinical benefits appeared almost worthless and biological data hardly improved. On the contrary, side effects such as leucopenia, malaise, mental confusion proved quite impressive. From these 2 observations it might be concluded that interferon is not the treatment of choice of Kaposi’s sarcoma. Transfer factor, much more easy to use, displayed transient efficacity in 1 patient. Fundamentals about Kaposi’s sarcoma and interferon are reviewed.

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Is Presence of Interferon Predictive for Aids?

Cited by 48 publications

References 5 publications

Type I interferons suppress viral replication but contribute to T cell depletion and dysfunction during chronic HIV-1 infection

Type I interferons suppress viral replication but contribute to T cell depletion and dysfunction during chronic HIV-1 infection

Plasmacytoid Dendritic Cells Suppress HIV-1 Replication but Contribute to HIV-1 Induced Immunopathogenesis in Humanized Mice

Sarcome de Kaposi: traitement par facteur de transfert et interféron-alpha-2

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