Is povidone iodine mouthwash effective against SARS‐CoV‐2? First in vivo tests

Lamas, Lucía Martínez; Dios, Pedro Diz; Pérez-Rodríguez, M. Teresa; Pérez, Victor Del Campo; Cabrera-Alvargonzález, Jorge Julio; Domínguez, Ana María López; Feijoo, Javier Fernández; Diniz‐Freitas, Márcio; Posse, Jacobo Limeres

doi:10.1111/odi.13526

Cited by 98 publications

(114 citation statements)

References 13 publications

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“…37 On the basis of an in vitro study demonstrating inactivation of SARS-CoV-2 and a small case series showing a significant reduction in COVID-19 viral loads in 2 of 4 patients using a povidone-iodine mouthwash, we have started to use 0.5% povidone-iodine irrigation during our mastoidectomy procedures. 38,39 Samplers that are commonly used for bioaerosol sampling are not designed to collect nanosized viral aerosols. 14…”

Section: Discussionmentioning

confidence: 99%

Airborne Aerosolized Mouse Cytomegalovirus From Common Otolaryngology Procedures: Implications for COVID‐19 Infection

Sayahi

Nielson

et al. 2020

Otolaryngol.--head neck surg.

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Objectives To determine whether common otolaryngology procedures generate viable aerosolized virus through a murine cytomegalovirus (mCMV) model for infection. Study Design mCMV model of infection. Setting University of Utah laboratory. Methods Three-day-old BALB/c mice were inoculated with mCMV or saline. Five days later, each mouse underwent drilling, microdebrider, coblation, and electrocautery procedures. Particle size distribution and PM2.5 (particulate matter <2.5 µm) concentration were determined with a scanning mobility particle sizer and an aerosol particle sizer in the range of 15 nm to 32 µm. Aerosolized samples from these procedures were collected with an Aerosol Devices BioSpot sampler for viral titer based on polymerase chain reaction and for viable virus through viral culture. Results As compared with the background aerosol concentrations, coblation and electrocautery showed statistically significant increases in airborne aerosols (Tukey-adjusted P value <.040), while microdebrider and drilling at 30,000 rpm did not (.870 < Tukey-adjusted P value < .930). We identified viral DNA in samples from coblation and drilling procedures, although we did not identify viable viruses in aerosol samples from any of the 4 procedures. Conclusion Coblation and electrocautery procedures generate >100-fold increases in aerosol concentrations over background; only coblation and drilling produce aerosolized viral DNA. The high concentration of aerosols from coblation and electrocautery suggests the need for appropriate safeguards against particle exposure to health care workers. The presence of viral DNA from drilling and coblation procedures warrants the need for appropriate protection against droplet and aerosol exposure.

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Section: Discussionmentioning

confidence: 99%

Airborne Aerosolized Mouse Cytomegalovirus From Common Otolaryngology Procedures: Implications for COVID‐19 Infection

Sayahi

Nielson

et al. 2020

Otolaryngol.--head neck surg.

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“…The first case report on efficacy of mouth-rinses in reducing the SARS-CoV-2 viral load in the saliva was reported in Korea [ 10 ]. Subsequently, Martínez Lamas et al, 2020 in a case-series of four patients suggested that PI mouth-rinse could reduce the saliva viral load of SARS-CoV-2 in patients with higher viral loads [ 11 ]. A recent in vitro study has shown the efficacy virucidal activity of certain commercially available mouth-rinses against SARS-CoV-2 [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore

et al. 2020

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“…A partir da análise do impacto que um enxaguante bucal com povidine causou na carga viral salivar de SARS-CoV-2 em 4 pacientes com COVID-19, Martínez Lamas et al 50 identificaram que, até o momento, a eficácia do povidine contra SARS-CoV-2 não está confirmada. Contudo, mesmo diante das limitações do estudo, esses resultados preliminares in vivo sugeriram que um enxágue com povidine poderia reduzir a concentração da carga viral salivar de SARS-CoV-2 em pacientes com cargas virais mais altas.…”

Section: Discussionunclassified

Uso de enxaguante bucal na prática odontológica durante a pandemia de COVID-19

Brito¹,

Melo²,

Júnior³

et al. 2020

Arch Health Invest

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Introdução: A transmissão SARS-CoV-2 de humano para humano pode ocorrer e o risco de propagação no ar durante os procedimentos odontológicos geradores de aerossóis permanece uma preocupação. Acredita-se que um enxaguatório bucal antimicrobiano pré-operacional reduza o número de micróbios orais. No entanto, a eficácia do enxaguatório bucal pré-procedimento na redução do número de microrganismos disseminados por meio do aerossol gerado por procedimentos odontológicos ainda não está clara. Objetivo: avaliar através de uma revisão de literatura o uso de enxaguantes bucais na redução da carga viral do SARS-CoV-2. Materiais e Método: O levantamento literário para esta pesquisa foi realizado no período de dezembro de 2019 a 10 de agosto de 2020 nas bases de dados Scielo e Medline/PubMed. Na estratégia de busca, foram utilizadas as palavras “SARS-CoV-2”, “2019-nCoV”, “COVID-19”, “Dentistry”, “Odontologia”, “Odontología”, “Mouthwashes”, “Antissépticos Bucais” e “Antisépticos Bucales”. Resultados: Uma busca sistematizada foi realizada, foram encontrados 661 artigos, após a realização da leitura criteriosa dos artigos completos foram selecionados 42 artigos. 88% dos estudos indicavam o uso de Peróxido de hidrogênio a 1%, 76% indicavam Povidine 0,2% e apenas 19% o uso da Clorexidina a 0,12%. Conclusão: Os estudos presentes na literatura apresentam divergências nas indicações e porcentagens dos enxaguantes indicados. Os protocolos clínicos devem ser avaliados para reduzir o risco de transmissão e proteger pacientes e profissionais.Descritores: Infecções por Coronavírus; Betacoronavirus; Odontologia; Antissépticos Bucais.ReferênciasGe ZY, Yang LM, Xia JJ, Fu XH, Zhang YZ. Possible aerosol transmission of COVID-19 and special precautions in dentistry. J Zhejiang Univ Sci B. 2020;21(5):361-68. Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Transmission routes of 2019-nCoV and controls in dental practice. 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show abstract

Is povidone iodine mouthwash effective against SARS‐CoV‐2? First in vivo tests

Cited by 98 publications

References 13 publications

Airborne Aerosolized Mouse Cytomegalovirus From Common Otolaryngology Procedures: Implications for COVID‐19 Infection

Airborne Aerosolized Mouse Cytomegalovirus From Common Otolaryngology Procedures: Implications for COVID‐19 Infection

Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore

Uso de enxaguante bucal na prática odontológica durante a pandemia de COVID-19

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