Is polypropylene mesh material fundamentally safe for use as a reconstructive material in vaginal surgery: ICI‐RS 2019?

Tayrac, Renaud de; Kirschner‐Hermanns, Ruth; Veit‐Rubin, Nikolaus; Anding, Ralf

doi:10.1002/nau.24312

Cited by 18 publications

(11 citation statements)

References 41 publications

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“…Lighter, more porous and less stiff PP meshes have been reported to have a less negative impact on the metabolism of both collagen and elastin when compared with normal weight PP mesh. 29 PVDF has advantageous physiochemical and handling characteristics. Recent studies have shown the potentially favorable tissue reaction and biocompatibility of PVDF as a mesh material for pelvic floor repair.…”

Section: Discussionmentioning

confidence: 99%

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Transvaginal polytetrafluoroethylene mesh surgery for pelvic organ prolapse: 1‐year clinical outcomes

et al. 2020

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Objectives To evaluate the safety and efficacy of transvaginal mesh surgery using a polytetrafluoroethylene mesh to treat pelvic organ prolapse. Methods This prospective observational study included women undergoing transvaginal mesh surgery for pelvic organ prolapse that used new polytetrafluoroethylene mesh cut into a shape similar to that of Elevate. We evaluated the subjective and objective outcomes at 3 and 12 months, as well as postoperative complication rates. Results This study included 55 patients. The pelvic organ prolapse quantification scores improved significantly at 3 and 12 months after surgery compared with scores before surgery. In four patients (7.3%), a pelvic examination showed stage 2 objective recurrence without subjective symptoms. Clavien–Dindo grades 2 and 3 perioperative complications were observed in 9.1% and 1.8% of the patients, respectively. Vaginal mesh exposure occurred in one patient (1.8%) at the time of the 3‐month follow‐up evaluation. The mesh was exposed at the proximal midline of the anterior vaginal wall. Conclusions These findings show the safe and effective use of the polytetrafluoroethylene mesh for transvaginal mesh surgery.

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Section: Discussionmentioning

confidence: 99%

“…New materials are being considered. Lighter, more porous and less stiff PP meshes have been reported to have a less negative impact on the metabolism of both collagen and elastin when compared with normal weight PP mesh 29 . PVDF has advantageous physiochemical and handling characteristics.…”

Section: Discussionmentioning

confidence: 99%

Transvaginal polytetrafluoroethylene mesh surgery for pelvic organ prolapse: 1‐year clinical outcomes

et al. 2020

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“…Erst mit der Einführung des TVT ("tension free vaginal tape") durch Ulmsten et al [3] verbreitete sich ein günstiges und leicht zu verarbeitendes Material (Polypropylen), dessen Eigenschaften (Typ-1-Mesh nach Amid: monofilamentär, makroporös, leichtgewichtig, weich) den bis dahin verwendeten überlegen war. Aktuell wird das Polypropylen bei genauerer struktureller, mikrobiologischer und immunologischer Betrachtung als Standardmaterial der Beckenbodenchirurgie wieder kontrovers gesehen [20].…”

Section: Alloplastische Bänderunclassified

Therapiemöglichkeiten der weiblichen Belastungsinkontinenz

2021

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ZusammenfassungDie Jahrtausendwende ging in Bezug auf das Thema weibliche Inkontinenz mit vielen wesentlichen Änderungen einher, der Begriff Stressinkontinenz wurde von Belastungsinkontinenz abgelöst, die Integraltheorie von Petros u. Ulmsten sowie das Hammock-Modell von DeLancey erweiterten das Verständnis der weiblichen Inkontinenz, das TVT (Tension-free vaginal tape) setzte sich in kurzer Zeit weltumspannend als Therapiestandard durch. Die vielversprechend gestartete Stammzelltherapie wird trotz inzwischen vorliegender klinischer Studien kontrovers beurteilt. Etablierte Therapieverfahren sind zunächst die konservative Therapie mit gezieltem Beckenbodentraining, minimal-invasive Verfahren wie die suburethrale Injektion, klassische Operationsverfahren wie die Faszienzügelplastik und die Kolposuspension mit ihren Modifikationen sowie die alloplastischen suburethralen Bänder (TVT, TOT [Transobturator tape], SIS [Single incision sling]), entweder spannungsfrei oder adjustierbar. Die Operationsmethoden liefern auch im Langzeitverlauf insgesamt gute Ergebnisse bei geringerer Morbidität der Bandverfahren. In Anbetracht der weltweiten Zulassungsbeschränkungen alloplastischer Bänder sollten die urogynäkologische Expertise in klassischen Operationstechniken aufrechterhalten werden und neue Entwicklungen den IDEAL (Innovation, Development, Exploration, Assessment, Long-term study)-Empfehlungen folgen.

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“…The results obtained with PP are less consistent than other materials and have a variety of weakness in layer adhesion and general adhesion to the bed of the printer as could be observed throughout the print process of our cylinders. Furthermore, even though PP shows clinical benefits, such as its flexibility and tenacity, very useful in operations like hernia repairs and pelvic organ prolapse surgery [35,36], recent studies show that implants made with this material might cause a reaction in the body's immunologic system [30] and therefore we are concerned about possible implications derived from even a short term exposure to this material.…”

Section: Materials Strength Assessmentmentioning

confidence: 99%

3D Printing of Temporary Prostheses for Controlled-Release of Drugs: Design, Physical Characterization and Preliminary Studies

et al. 2021

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In recent years, the use of 3D printing technologies in orthopedic surgery has markedly increased, as they offer the possibility of printing personalized prostheses. The work presented in this article is a preliminary study of a research project which aims to manufacture customized spacers containing antibiotics for use in joint replacement surgery. The objective of this work was to design and print different 3D constructs to evaluate the use of different materials, their properties after the process of 3D printing, such as resistance, and the release kinetics of drugs from the constructs. Different designs and different materials were analyzed to obtain a 3D construct with suitable properties. Our design takes advantage of the micropores created between the layers of the 3D printed filaments to release the contained drug. Using polylactic acid (PLA) we were able to print cylindrical structures with interconnected micropores and a hollow chamber capable of releasing methylene blue, which was selected as a model drug. The final PLA 3D construct was printed with a 10% infill. The physical and technological characteristics, morphological changes at body temperature and interaction with water were considered to be acceptable. The PLA 3D printed constructs were found to have sufficient strength to withstand a force of 500 kg. The results obtained allow to continue research in this project, with the aim of manufacturing prostheses containing a reservoir of antibiotics or other drugs in their interior for their subsequent controlled release.

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Is polypropylene mesh material fundamentally safe for use as a reconstructive material in vaginal surgery: ICI‐RS 2019?

Cited by 18 publications

References 41 publications

Transvaginal polytetrafluoroethylene mesh surgery for pelvic organ prolapse: 1‐year clinical outcomes

Transvaginal polytetrafluoroethylene mesh surgery for pelvic organ prolapse: 1‐year clinical outcomes

Therapiemöglichkeiten der weiblichen Belastungsinkontinenz

3D Printing of Temporary Prostheses for Controlled-Release of Drugs: Design, Physical Characterization and Preliminary Studies

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