Is plasma caveolin-1 level a prognostic biomarker in metastatic pancreatic cancer?

Demi̇rci, Nebi̇ Serkan; Doğan, Mutlu; Erdem, Gökmen Umut; Kaçar, Sabite; Turan, Turhan; Kılıçkap, Saadettin; Cigirgan, Lutfi C; Kayaçeti̇n, Ertuğrul; Bozkaya, Yakup; Zengi̇n, Nurullah

doi:10.4103/sjg.sjg_483_16

Cited by 9 publications

(4 citation statements)

References 52 publications

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“…In cancer cells, Cav-1 has been shown to regulate a multitude of critical pro-tumorigenic functions including invasion ( 45 ), apoptosis ( 46 ), cell signaling ( 47 ), cholesterol metabolism ( 48 ), autophagy ( 49 ), metabolism ( 23 ), angiogenesis ( 22 ), and treatment resistance ( 19 , 50 ). Specifically, in patients with PDAC, our work and that of others have shown that elevated Cav-1 expression correlates with worse clinical outcomes ( 15 , 51 , 52 ). We showed that genetic ablation of CAV1 in the pancreata of mice that spontaneously developed pancreatic tumors resulted in longer survival and reduced tumor burden compared to CAV1 wild-type mice, corroborating our patient data that showed elevated Cav-1 expression in pancreatic cancer occurs late in the disease course and predicts poor prognosis for cancer progression (Fig.…”

Section: Discussionsupporting

confidence: 51%

Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions

Wolfe,

Cui,

Baie

et al. 2024

Sci. Adv.

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Pancreatic ductal adenocarcinoma (PDAC) is characterized by its nutrient-scavenging ability, crucial for tumor progression. Here, we investigated the roles of caveolae-mediated endocytosis (CME) in PDAC progression. Analysis of patient data across diverse datasets revealed a strong association of high caveolin-1 (Cav-1) expression with higher histologic grade, the most aggressive PDAC molecular subtypes, and worse clinical outcomes. Cav-1 loss markedly promoted longer overall and tumor-free survival in a genetically engineered mouse model. Cav-1–deficient tumor cell lines exhibited significantly reduced proliferation, particularly under low nutrient conditions. Supplementing cells with albumin rescued the growth of Cav-1–proficient PDAC cells, but not in Cav-1–deficient PDAC cells under low glutamine conditions. In addition, Cav-1 depletion led to significant metabolic defects, including decreased glycolytic and mitochondrial metabolism, and downstream protein translation signaling pathways. These findings highlight the crucial role of Cav-1 and CME in fueling pancreatic tumorigenesis, sustaining tumor growth, and promoting survival through nutrient scavenging.

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Section: Discussionsupporting

confidence: 51%

Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions

Wolfe,

Cui,

Baie

et al. 2024

Sci. Adv.

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“…In breast cancer, CAV1 activity has been shown to be associated with resistance to radio-and chemotherapy (Qian et al 2019). High CAV1 levels have been reported in pancreatic cancer (Demirci et al 2017), while decreased CAV1 levels were observed in colorectal cancer (Torrejón et al 2017) and hepatocellular carcinoma (Tang et al 2012). Furthermore, Yang et al noticed that a high CAV1 level reduces the metastatic potential of colon cells (line SW480) and may indicate a promising outcome in patients with this cancer (Yang et al 2018).…”

Section: Discussionmentioning

confidence: 99%

The influence of selected microRNAs on the expression profile of genes and proteins related to the tumor necrosis factor-alpha signaling pathways in endometrioid endometrial cancer

Zmarzły¹,

Januszyk²,

Mieszczański

et al. 2023

J Cancer Res Clin Oncol

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Purpose Tumor necrosis factor exerts many adverse biological effects, from cell proliferation to cell death. Accurate diagnosis and treatment are therefore difficult due to many factors influencing tumor necrosis factor-alpha (TNF-α) signaling, including microRNAs (miRNAs), especially in tumors. The aim of the study was to determine the influence of miRNAs on the expression profile of genes and proteins related to TNF-α signaling in endometrial cancer. Methods The material consisted of 45 endometrioid endometrial cancer and 45 normal endometrium tissue samples. Gene expression was determined with microarrays and then validated for TNF-α, tumor necrosis factor receptor 1 (TNFR1) and 2 (TNFR2), caveolin 1 (CAV1), nuclear factor kappa B subunit 1 (NFKB1), and TGF-beta activated kinase 1 (MAP3K7)-binding protein 2 (TAB2) using real-time quantitative reverse transcription reaction (RT-qPCR). The protein concentration was assessed by enzyme-linked immunosorbent assay (ELISA). In addition, differentiating miRNAs were identified using miRNA microarrays and their relationships with TNF-α signaling genes were evaluated using the mirDIP tool. Results TNF-α, TNFR1, TNFR2, CAV1, NFKB1, and TAB2 were upregulated both on the mRNA and protein levels. The decrease in the activity of miR-1207-5p, miR-1910-3p, and miR-940 may be related to CAV1 overexpression. Similarly for miR-572 and NFKB1 as well as miR-939-5p and TNF-α. In turn, miR-3178 may partially inhibit TNFR1 activity up to grade 2 cancer. Conclusion TNF-α signaling, especially the TNF-α/NF-κB axis, is disrupted in endometrial cancer and worsens with disease progression. The observed changes may be the result of miRNAs’ activity in the initial stage of endometrial cancer and its gradual loss in later grades.

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“…Several blood biomarkers, such as carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic antigen (CEA), lactate dehydrogenase, caveolin-1, C-reactive protein, and cathepsin L, have prognostic importance in pancreatic cancer. [6–9]…”

Section: Introductionmentioning

confidence: 99%

“…Several blood biomarkers, such as carbohydrate antigen , carcinoembryonic antigen (CEA), lactate dehydrogenase, caveolin-1, C-reactive protein, and cathepsin L, have prognostic importance in pancreatic cancer. [6][7][8][9] These markers are inexpensive and simple to evaluate in blood samples. However, due to the poor prognosis of patients with pancreatic cancer, novel biomarkers are still required to determine the prognosis of the disease and predict the response to treatment.…”

Section: Introductionmentioning

confidence: 99%

Is the serum level of survivin, an antiapoptotic protein, a potential predictive and prognostic biomarker in metastatic pancreatic cancer?

et al. 2023

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In the present study, we aimed to assess the association between the serum survivin level and overall survival and treatment response rates in metastatic pancreatic cancer (MPC). Serum samples were prospectively collected from 41 patients with newly diagnosed MPC patients and 41 healthy individuals (control group) to assess the survivin levels. The median survivin level was 136.2 ng/mL in patients with MPC and 52 ng/mL in healthy individuals (P = .028). Patients were divided into low- and high-survivin groups according to the baseline median survivin level. Patients with a high serum survivin level compared with a low serum survivin level had shorter median progression-free survival (2.39 vs 7.06 months; P = .008, respectively) and overall survival (3.74 vs 9.52 months; P = .026, respectively). Patients with higher serum survivin levels had significantly worse response rates (P = .007). The baseline high level of serum survivin in patients with MPC may be associated with treatment resistance and poor prognosis. A confirmation will be needed for these results in future large multicenter prospective studies.

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Is plasma caveolin-1 level a prognostic biomarker in metastatic pancreatic cancer?

Cited by 9 publications

References 52 publications

Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions

Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions

The influence of selected microRNAs on the expression profile of genes and proteins related to the tumor necrosis factor-alpha signaling pathways in endometrioid endometrial cancer

Is the serum level of survivin, an antiapoptotic protein, a potential predictive and prognostic biomarker in metastatic pancreatic cancer?

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