Is physical activity a protective factor against pancreatic cancer?

Kollarova, Hellena; Azeem, Kateřina; Tomášková, Hana; Horáková, D; Procházka, Vladimír; Martínek, Arnošt; Shonová, Olga; Ševčíková, Jarmila; Sevcikova, V.; Janout, Vladimí­r

doi:10.4149/bll_2014_091

Cited by 8 publications

(14 citation statements)

References 16 publications

(19 reference statements)

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“…That is why risk factors for PDA are an important issue. It appears, from descriptive and retrospective studies, that tobacco smoking and aging are seriously involved in the development of pancreatic cancer [1, 2, 6, 7, 14, 18, 19]. It was reported that smoking is responsible for nearly 25% of PDA, and that carbon monoxide, benzene, vinyl chloride, and many other compounds play a destructive role not only in the development, but also in the progression of PDA.…”

Section: Risk Factorsmentioning

confidence: 99%

“…That is why our weight is one of the most important factors of our health. If we are becoming overweight earlier in life, we have a greater risk of consuming carcinogenic substances, energy imbalance, and inflammation [1, 3, 4, 6, 8, 15, 18]. …”

Section: Risk Factorsmentioning

confidence: 99%

“…Some authors hypothesise that physical activity reduces glucose levels and unhealthy triglycerols, and prevent type 2 diabetes mellitus, which can reduce PDA thereafter. It was proven that physical exercise protects against being overweight and obese, and can reduce insulin resistance [1, 6, 10, 13]. …”

Section: Risk Factorsmentioning

confidence: 99%

“…When PDA spreads to other organs, as in stage IV, the five-year survival rate is below 2%. Unfortunately, more than 50% of PDA patients are diagnosed in stage IV [1]. Worldwide PDA is the fourth leading cause of cancer-related mortality.…”

Section: Introductionmentioning

confidence: 99%

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Prevention of pancreatic cancer

Kuroczycki-Saniutycz¹,

Grzeszczuk

Zwierz³

et al. 2017

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Pancreatic ductal adenocarcinoma (PDA) accounts for 95% of all pancreatic cancers. About 230,000 PDA cases are diagnosed worldwide each year. PDA has the lowest five-year survival rate as compared to others cancers. PDA in Poland is the fifth leading cause of death after lung, stomach, colon and breast cancer.In our paper we have analysed the newest epidemiological research, some of it controversial, to establish the best practical solution for pancreatic cancer prevention in the healthy population as well as treatment for patients already diagnosed with pancreatic cancer.We found that PDA occurs quite frequently but is usually diagnosed too late, at its advanced stage. Screening for PDA is not very well defined except in subgroups of high-risk individuals with genetic disorders or with chronic pancreatitis.We present convincing, probable, and suggestive risk factors associated with pancreatic cancer, many of which are modifiable and should be introduced and implemented in our society.

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Section: Risk Factorsmentioning

confidence: 99%

Section: Risk Factorsmentioning

confidence: 99%

Section: Risk Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevention of pancreatic cancer

Kuroczycki-Saniutycz¹,

Grzeszczuk

Zwierz³

et al. 2017

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“…However, other evidence suggest that mTOR may also play a positive role in cancer patients. It has been demonstrated that physical exercise stimulates the mTOR pathway and this is correlated with the prevention of certain type of cancers [34][35][36]. mTOR can also increase tolerability of chemotherapy and can protect against autophagy (frequently associate with cancer resistance to therapy) and improve prognosis [37][38][39].…”

Section: Amino Acids Supplementation As a Cancer Fighting Weaponmentioning

confidence: 99%

Nutrition, Nitrogen Requirements, Exercise and Chemotherapy-Induced Toxicity in Cancer Patients. A puzzle of Contrasting Truths?

Flati¹,

Corsetti²,

Pasini³

et al. 2015

ACAMC

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Amino acids can modulate cell metabolism and control cell fate by regulating cell survival and cell death. The molecular mechanisms involved are mediated by the mTOR complexes mTORC1 and mTORC2 activity. These complexes are finely regulated and the continuous advancement of the knowledge on their composition and function is revealing that their balance may represent the condition that determines the cell fate. This is important for normal healthy cells but it is becoming clear, and it is even more important, that the balance of the mTORCs activity may also condition the cell fate of cancer cells. Here, we discuss the evidences supporting the amino acids supplementation as a cancer fighting weapon and a possible strategy to counteract the myocyte toxicity associated with chemotherapy, possibly by tipping the balance of mTORCs activity.

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Environmental risk factors for pancreatic cancer: an update

et al. 2016

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Pancreatic cancer (PC) is one of the most aggressive diseases. Only 10 % of all PC cases are thought to be due to genetic factors. Here, we analyzed the most recently published case-control association studies, meta-analyses, and cohort studies with the aim to summarize the main environmental factors that could have a role in PC. Among the most dangerous agents involved in the initiation phase, there are the inhalation of cigarette smoke, and the exposure to mutagenic nitrosamines, organ-chlorinated compounds, heavy metals, and ionizing radiations. Moreover, pancreatitis, high doses of alcohol drinking, the body microbial infections, obesity, diabetes, gallstones and/or cholecystectomy, and the accumulation of asbestos fibers seem to play a crucial role in the progression of the disease. However, some of these agents act both as initiators and promoters in pancreatic acinar cells. Protective agents include dietary flavonoids, marine omega-3, vitamin D, fruit, vegetables, and the habit of regular physical activity. The identification of the factors involved in PC initiation and progression could be of help in establishing novel therapeutic approaches by targeting the molecular signaling pathways responsive to these stimuli. Moreover, the identification of these factors could facilitate the development of strategies for an early diagnosis or measures of risk reduction for high-risk people.

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Is physical activity a protective factor against pancreatic cancer?

Cited by 8 publications

References 16 publications

Prevention of pancreatic cancer

Prevention of pancreatic cancer

Nutrition, Nitrogen Requirements, Exercise and Chemotherapy-Induced Toxicity in Cancer Patients. A puzzle of Contrasting Truths?

Environmental risk factors for pancreatic cancer: an update

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