Is personality associated with dementia risk? A meta-analytic investigation

Aschwanden, Damaris; Strickhouser, Jason E.; Luchetti, Martina; Stéphan, Yannick; Sutin, Angelina R.; Terracciano, Antonio

doi:10.1016/j.arr.2021.101269

Cited by 83 publications

(59 citation statements)

References 82 publications

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“…The findings indicate that a higher neuroticism score increases risk of neurodegenerative diseases even among people who do not meet the clinical criteria for psychiatric disorders. With the progression of PD, patients who score higher on neuroticism are also at higher risk of developing comorbid anxiety and mood disorders, higher risk of dementia, 9 and experience worse quality of life. 32 The findings have also implications for research and resonate with the National Institutes of Health emphasis on the research domain criteria framework.…”

Section: Discussionmentioning

confidence: 99%

“…Individuals who score high in neuroticism are at higher risk for poor health outcomes across the lifespan, particularly in the domain of mental health [2][3][4] and neurodegenerative diseases, including Alzheimer's disease and related dementias. [5][6][7][8][9] Relatively less is known about the association between neuroticism and Parkinson's disease (PD), 10,11 a multifactorial neurodegenerative disorder characterized by bradykinesia, resting tremor, rigidity, and may include autonomic dysfunctions, cognitive deficits, and mood disorders. 12 The prevalence of PD is about 1% in older adults, 13 and globally it is estimated that over 6 million individuals have PD.…”

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confidence: 99%

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Neuroticism and Risk of Parkinson's Disease: A Meta‐Analysis

et al. 2021

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A BS TRACT: Background: Neuroticism is linked to mood disorders and Alzheimer's disease, but fewer studies have tested the prospective association with Parkinson's disease (PD). Objectives: To examine the association between neuroticism and risk of PD in a large cohort and a meta-analysis of prospective cohort studies. Methods: Participants from the UK Biobank (N = 490,755) completed a neuroticism scale in 2006-2010. Incident PD was ascertained using electronic health records or death records up to 2018. The systematic search and metaanalysis followed the MOOSE guidelines. Results: During 11.91 years of follow-up (mean = 8.88 years; 4,360,105 person-years) 1142 incident PD cases were identified. Neuroticism was associated with higher risk of incident PD, both as continuous (HR = 1.28; 95% CI: 1.21-1.36) and categorical variable (top vs. bottom quartiles: HR = 1.88; 95% CI: 1.60-2.22). The association remained significant after accounting for age, sex, smoking, physical activity, anxiety, and depressed mood, and after excluding cases that occurred within the first 5 years of follow-up. The associations were similar for women and men and across levels of socioeconomic status. Random-effect meta-analysis of four prospective studies (N = 548,284) found neuroticism associated with increased risk of incident PD (HR = 1.82; 95% CI: 1.59-2.08; P = 7.31 −19 ). There was no evidence of heterogeneity across studies with follow-ups ranging from one to four decades. Conclusion:The results from the large UK Biobank and meta-analysis of prospective studies indicate that neuroticism is consistently associated with a higher risk of incident PD.

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Section: Discussionmentioning

confidence: 99%

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Neuroticism and Risk of Parkinson's Disease: A Meta‐Analysis

et al. 2021

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“…Moreover, extraversion was the only personality trait that was significantly related to change in depression. Most studies that explored the relationship between agreeableness and dementia reported a negative association ( Aschwanden et al, 2021 ; Terracciano et al, 2014 , 2017 ). Notably, agreeableness was strongly associated with a better performance of four out of the five cognitive domains in another study ( Sutin et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Do Personality Traits Influence the Association Between Depression and Dementia in Old Age?

Adaralegbe

Egbuchiem²,

Adeoti

et al. 2022

Gerontology and Geriatric Medicine

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Depression and personality traits are independent predictors of dementia or cognitive impairment. Despite the well-established relationship between these two psychosocial factors and dementia, no research has been documented on how personality traits can influence dementia in older adults exhibiting depressive symptoms. This study explores the influence of personality traits on the association between change in depression and dementia in old age. A population-based longitudinal cohort study involving two waves of data collected 5 years apart, containing 2210 American older adults, from the National Social Life, Health, and Aging Project to explore if personality traits influence how change in depression predicts the development of dementia. We assessed these relationships while adjusting for sociodemographic characteristics. Change in depression increased the likelihood of dementia at T2 by 4.2% (AOR = 1.04, p = 0.019) in the co-variate adjusted model. Personality traits, overall, did not influence how depression predicts the development of dementia. However, agreeableness individually nullified the effect of depression on the development of dementia, whereas extraversion was the only personality trait that significantly predicted dementia. Prosocial behaviors should be promoted in old age as these appear to be protective. In addition, early life education and a strong social support can keep the depression–dementia spectrum at bay in old age.

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“…Many experts have shown symptomatic identity in dementia and ASD [ 38 ]. Recently, in a meta-analysis of 12 studies, researchers declared Alzheimer’s disease the most common type of dementia, although they could not significantly differentiate between AD and dementia [ 9 , 39 ]. Some other studies have considered AD to be one of the major causes of dementia [ 40 ].…”

Section: Shared Symptoms Of Asd and Admentioning

confidence: 99%

Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer’s Disease

et al. 2021

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Autism spectrum disorder (ASD) and Alzheimer’s disease (AD) are neurodevelopmental and neurodegenerative disorders affecting two opposite ends of life span, i.e., childhood and old age. Both disorders pose a cumulative threat to human health, with the rate of incidences increasing considerably worldwide. In the context of recent developments, we aimed to review correlated symptoms and genetics, and overlapping aspects in the mechanisms of the pathogenesis of ASD and AD. Dementia, insomnia, and weak neuromuscular interaction, as well as communicative and cognitive impairments, are shared symptoms. A number of genes and proteins linked with both disorders have been tabulated, including MECP2, ADNP, SCN2A, NLGN, SHANK, PTEN, RELN, and FMR1. Theories about the role of neuron development, processing, connectivity, and levels of neurotransmitters in both disorders have been discussed. Based on the recent literature, the roles of FMRP (Fragile X mental retardation protein), hnRNPC (heterogeneous ribonucleoprotein-C), IRP (Iron regulatory proteins), miRNAs (MicroRNAs), and α-, β0, and γ-secretases in the posttranscriptional regulation of cellular synthesis and processing of APP (amyloid-β precursor protein) have been elaborated to describe the parallel and overlapping routes and mechanisms of ASD and AD pathogenesis. However, the interactive role of genetic and environmental factors, oxidative and metal ion stress, mutations in the associated genes, and alterations in the related cellular pathways in the development of ASD and AD needs further investigation.

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Is personality associated with dementia risk? A meta-analytic investigation

Cited by 83 publications

References 82 publications

Neuroticism and Risk of Parkinson's Disease: A Meta‐Analysis

Neuroticism and Risk of Parkinson's Disease: A Meta‐Analysis

Do Personality Traits Influence the Association Between Depression and Dementia in Old Age?

Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer’s Disease

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