Is peritoneal dialysis causing a measurable burden of inflammatory and endothelial injury on top of metabolic syndrome?

Miler, Marijana; Nikolac, Nora; Šegulja, Dragana; Maslac, S. Kackov; Ćelap, Ivana; Altabas, Karmela; Šefer, Siniša; Šimundić, Ana-Maria

doi:10.1007/s40618-016-0540-7

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…The elevation of CRP and proinflammatory cytokines, such as IL‐6, due to the interaction between blood and dialyzer membrane is an important contributing factor in HD patients . Some recent studies report that in PD patients, endothelial dysfunction and oxidative stress cause subtle chronic inflammation . Interestingly, chronic inflammation leads to higher occurrence of NODM in PD patients .…”

Section: Diagnosis Of Nodm In Pd Patientsmentioning

confidence: 99%

New‐Onset Diabetes Mellitus in Peritoneal Dialysis and Hemodialysis Patients: Frequency, Risk Factors, and Prognosis—A Review

2019

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New‐onset diabetes mellitus (NODM) is observed in both hemodialysis (HD) and peritoneal dialysis (PD) patients. The prevalence of NODM in dialysis patients is slightly higher compared to subjects of the general population. Based on currently published data there is no convincing evidence that the risk of NODM is different between HD and PD patients. Data on the effect of glucose load on risk of NODM in dialysis patients remain controversial. PD modality (automated or continuous ambulatory PD) has no significant influence on NODM incidence. Chronic inflammation is associated with NODM in dialysis patients. Reported differences in NODM between PD and HD patients are possibly also influenced by differences in demographic factors between these patient groups. Mortality in NODM patients is lower than mortality in patients with preexisting DM. This may be partly explained by the younger age and lower number of comorbidities in patients with NODM.

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Section: Diagnosis Of Nodm In Pd Patientsmentioning

confidence: 99%

New‐Onset Diabetes Mellitus in Peritoneal Dialysis and Hemodialysis Patients: Frequency, Risk Factors, and Prognosis—A Review

2019

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“…Patients with MS who are receiving PD always have low-grade, chronic inflammation. 21,22 Our findings may indicate a stronger inflammatory reaction in patients with MS than in those without MS. MS has been reported as an independent risk marker for CVD morbidity and mortality in patients without DM who are undergoing PD. 1,23 Patients with MS had a higher risk of arteriosclerosis incidence than those without MS.…”

Section: Discussionmentioning

confidence: 68%

Clinical characterization and prognostic implications of metabolic syndrome in patients undergoing peritoneal dialysis at a Chinese center

et al. 2019

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ObjectiveMetabolic syndrome (MS) is a common clinical condition associated with cardiovascular disease in patients undergoing peritoneal dialysis (PD); however, its prognostic implication among patients receiving PD remains controversial.MethodsIn a prospective study from January 2013 and June 2016, we enrolled 190 patients undergoing PD and followed them for 46.4 ± 30.7 months. We assessed the associations of clinical characteristics and measurements with diabetes mellitus (DM) status, MS, and prognostic outcomes among the included patients.ResultsWe found that DM was associated with shortened duration of dialysis and poor survival. The prevalence of MS was 58.9% among all patients. We found significant differences in age, body weight, body mass index, triglycerides, high-density lipoprotein cholesterol, fasting plasma glucose, leukocytes, platelets, neutrophil percentage, and pre-albumin between patients with and without MS. We found a negative correlation trend between serum intact parathyroid hormone and MS among our patients. The arteriosclerosis index was significantly elevated in the MS group compared with the non-MS group. Serum calcium concentration and frequency of hospital admissions were significantly associated with mortality and technique failure.ConclusionsMS was positively associated with cardiovascular disease. DM, and hypocalcemia. Frequent hospital admissions can predict poor prognosis in patients undergoing PD.

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“…Malnutrition may affect the normal function of the vascular endothelium, leading to abnormal regulation of vasodilation and constriction, thereby increasing the risk of cardiovascular events. [36,37] Notably, although no significant association of the GNRI with technique failure or peritonitis was observed, only 2 included studies performed relevant explorations. Therefore, it is still necessary to identify the predictive role of the GNRI for technique failure and peritonitis among PD patients in future research.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between the geriatric nutritional risk index and clinical outcomes among peritoneal dialysis patients: A meta-analysis

Wang,

Liang,

Jiang

2024

Medicine

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Background: To identify the relationship between the geriatric nutritional risk index (GNRI) and clinical outcomes in patients receiving peritoneal dialysis (PD). Methods: The PubMed, EBASE, Web of Science and CNKI databases were searched for available studies up to December 25, 2023. The primary outcome was all-cause mortality, and the secondary outcomes included the incidence of PD dropout, major adverse cardiac and cerebrovascular events (MACCEs), technique failure and peritonitis. Hazard ratios (HRs) and 95% confidence intervals (CIs) were combined to evaluate the predictive value of the GNRI for the occurrence of the above endpoints. Results: Ten cohort studies with 3897 patients were included. The pooled results demonstrated that a lower GNRI was significantly associated with a greater incidence of all-cause mortality (HR = 0.71, 95% CI: 0.55–0.91; P = .007). In addition, a decreased GNRI predicted the occurrence of dropout from PD (HR = 0.971, 95% CI: 0.945–0.998, P = .034) and MACCE (HR = 0.95, 95% CI: 0.92–0.98, P = .001). However, no significant associations of the GNRI with technique failure (P = .167) or peritonitis (P = .96) were observed. Conclusion: A low GNRI is significantly associated with poor clinical outcomes and might serve as a novel and valuable prognostic indicator among PD patients.

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Is peritoneal dialysis causing a measurable burden of inflammatory and endothelial injury on top of metabolic syndrome?

Abstract: In patients on PD, inflammatory reaction is higher than in patients with MS. On the contrary, patients with MS have stronger oxidative stress response and adipose tissue activity caused probably by the chronic low level of inflammation and underlying metabolic disorders.

Cited by 3 publications

References 22 publications

New‐Onset Diabetes Mellitus in Peritoneal Dialysis and Hemodialysis Patients: Frequency, Risk Factors, and Prognosis—A Review

New‐Onset Diabetes Mellitus in Peritoneal Dialysis and Hemodialysis Patients: Frequency, Risk Factors, and Prognosis—A Review

Clinical characterization and prognostic implications of metabolic syndrome in patients undergoing peritoneal dialysis at a Chinese center

Association between the geriatric nutritional risk index and clinical outcomes among peritoneal dialysis patients: A meta-analysis

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