Is periodontitis a risk factor for infections in cirrhotic patients?

Profio, Bruna Di; Villar, Cristina Cunha; Saraiva, Luciana; Ortega, Karem L.; Pannuti, Cláudio Mendes

doi:10.1016/j.mehy.2017.06.022

Cited by 7 publications

(5 citation statements)

References 70 publications

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“…The practical implications of the findings of our study are that considering the poor periodontal condition of LTCs, dental and periodontal care should be given to cirrhotic patients on the waiting list. The altered immunological defense of patients with cirrhosis has been associated with increased prevalence of systemic infections .…”

Section: Discussionmentioning

confidence: 81%

“…The altered immunological defense of patients with cirrhosis has been associated with increased prevalence of systemic infections . It has been postulated that periodontal pathogens may translocate from periodontal pockets to distant sites, where they may cause development of infections, what may result in cancellation or postponement of a transplantation surgery . Consequently, periodontal care should assume a key role in the management of patients with liver disease, particularly those on the waiting list.…”

Section: Discussionmentioning

confidence: 99%

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Periodontal status of liver transplant candidates and healthy controls

Profio

Inoue

Marui

et al. 2018

Journal of Periodontology

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Periodontal status of liver transplant candidates and healthy controls

Profio

Inoue

Marui

et al. 2018

Journal of Periodontology

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“…The chronic inflammatory response to bacterial plaques results in periodontitis, an epidemic that causes periodontal inflammation featuring tartar deposition on the teeth. This accumulation potentially leads to loss of the periodontal ligament and alveolar bone 1 . Generally, periodontitis upregulates pro-inflammatory cytokines, which stimulate inflammatory cells and destroy the alveolar bone 2 .…”

Section: Introductionmentioning

confidence: 99%

Ixeris dentata and Lactobacillus gasseri media protect against periodontitis through Nrf2-HO-1 signalling pathway

Lee

Kim

et al. 2023

Sci Rep

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Periodontitis is an infectious inflammation in the gums characterized by loss of periodontal ligaments and alveolar bone. Its persistent inflammation could result in tooth loss and other health issues. Ixeris dentata (IXD) and Lactobacillus gasseri media (LGM) demonstrated strong antioxidant activity, which may prevent oxidative and inflammatory periodontitis. Here, IXD and LGM extracts were investigated for antioxidative activity against oral discomfort and evaluated for their synergistic effect against oxidative and inflammatory periodontitis in a mouse model. IXD/LGM suppressed pro-inflammatory cytokines like interleukin (IL)-1β, IL-6, and TNF-α. Additionally, it reduced pro-inflammatory mediators, nitric oxide, iNOS (inducible nitric oxide synthase), and COX-2 (cyclooxygenase-2) and enhanced AKT, Nrf2, and HO-1 activation. Similarly, IXD/LGM treatment elevated osteogenic proteins and mRNAs; alkaline phosphatase, collagen type 1 (COL1), osteopontin (OPN), and runt-related transcription factor 2 (RUNX2). Hematoxylin and Eosin (H&E) staining and micro-CT analysis confirm the positive impact of IXD/LGM on the periodontal structure and its associated inflammation. These findings demonstrate that IXD/LGM inhibits oxidative stress, periodontal inflammation, and its resultant alveolar bone loss in which Akt (also known as protein kinase B)-nuclear factor-erythroid 2-related factor 2 (Nrf2)-hemoxygenase-1 (HO-1) signaling is involved. Thus, IXD/LGM is a potential candidate against oxidative/inflammatory stress-associated periodontitis.

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“…Periodontitis results from chronic inflammatory reaction to bacterial plaques and is an epidemic that causes periodontal inflammation, which is characterized by the accumulation of tartar on the teeth and loss of the periodontal ligament (PDL) and alveolar bone [1,2], Periodontitis results in the upregulation of pro-inflammatory cytokines that stimulate inflammatory cells and destroy connective tissues, such as the PDL and alveolar bone [3]. In various pathogen-related molecular patterns, including inflammatory responses to lipopolysaccharides (LPS), tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-1 are activated by the formation of nitric oxide (NO) and prostaglandin E2 (PGE2), which are synthesized by inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively [4].…”

Section: Introductionmentioning

confidence: 99%

Panax ginseng Fruit Has Anti-Inflammatory Effect and Induces Osteogenic Differentiation by Regulating Nrf2/HO-1 Signaling Pathway in In Vitro and In Vivo Models of Periodontitis

Kim

Park

et al. 2020

Antioxidants

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Periodontitis is an infectious inflammatory disease of tissues around teeth that destroys connective tissues and is characterized by the loss of periodontal ligaments and alveolar bone. A new treatment strategy is needed owing to the limitations of the current surgical treatment method and the side effects of anti-inflammatory drugs. Therefore, here, we assessed whether Panax ginseng fruit extract (PGFE) is a new therapeutic agent for periodontitis in vitro and in vivo. According to the results, PGFE suppressed pro-inflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β, and IL-6, and pro-inflammatory mediators such as inducible nitric oxide synthase and cyclooxygenase-2 through heme oxygenase-1 expression in human periodontal ligament cells stimulated with Porphyromonas gingivalis lipopolysaccharide (PG-LPS). In addition, the osteogenic induction of human periodontal ligament cells was inhibited by PG-LPS, and protein and mRNA levels of osteogenic markers such as alkaline phosphatase, collagen type 1 (COL1), osteopontin (OPN), and runt-related transcription factor 2 (RUNX2) were increased. The efficacy of PGFE for inhibiting periodontitis in vitro was demonstrated in a representative in vitro model of periodontitis induced by ligature and PG-LPS. Subsequently, hematoxylin and eosin staining and micro-computed tomography of the euthanized experimental animal model confirmed suppressed periodontal inflammation, which is an important strategy for treating periodontitis and for recovering the resulting alveolar bone loss. Therefore, PGFE is a potential, novel therapeutic agent for periodontal diseases.

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Is periodontitis a risk factor for infections in cirrhotic patients?

Cited by 7 publications

References 70 publications

Periodontal status of liver transplant candidates and healthy controls

Periodontal status of liver transplant candidates and healthy controls

Ixeris dentata and Lactobacillus gasseri media protect against periodontitis through Nrf2-HO-1 signalling pathway

Panax ginseng Fruit Has Anti-Inflammatory Effect and Induces Osteogenic Differentiation by Regulating Nrf2/HO-1 Signaling Pathway in In Vitro and In Vivo Models of Periodontitis

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