Is Overt Stuttered Speech a Prerequisite for the Neural Activations Associated with Chronic Developmental Stuttering?

Ingham, Roger J.; Fox, Peter T.; Ingham, Janis C.; Zamarripa, Frank

doi:10.1006/brln.2000.2351

Cited by 92 publications

(71 citation statements)

References 52 publications

(54 reference statements)

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“…Using MEG, Biermann-Ruben et al (2005) showed that both the left inferior frontal and the right rolandic areas of stuttering speakers played similar roles in speech perception and production. Ingham et al (2000) found similar types of neural differences between stuttering and non-stuttering speakers during imagined stuttering (i.e., speech planning without execution) and overt stuttering. These two studies seem to suggest that stuttering speakers differ from non-stuttering speakers in their brain activations regardless of the stage of speech process.…”

Section: Introductionmentioning

confidence: 69%

“…Correspondingly, we also found an additional backprojection from the left PMA to the right cerebellum among stuttering speakers, which was absent among non-stuttering controls. This backprojection may be closely related to the widely reported overactivation of the right cerebellum in stuttering speakers (e.g., Braun et al, 1997;Fox et al, 1996;Ingham et al, 2000). The alteration in the cerebellum-PMA circuit indicates that when producting rapid rhythmic speech, the motor cortex of stuttering speakers may be out-ofcontrol even when the linguistic plan is intact.…”

Section: The Neural Substrates For Atypical Execution Process In Stutmentioning

confidence: 80%

“…The contribution from the left IFG to the discrimination of stuttering is consistent with the altered anatomical structure (i.e., reduced grey matter volume and fractional anisotropy) in this region among stuttering children . However, among previous functional imaging studies, some reported the involvement of the left IFG in stuttering (e.g., Braun et al, 1997;De Nil et al, 2008;Lu et al, 2009;Neumann et al, 2003;Watkins et al, 2008;Wu et al, 1995), whereas others did not (Chang et al, 2009;Fox et al, 2000;Ingham et al, 2000). This discrepency may have resulted from the fact that previous studies did not separately examine planning and execution processes in which the left IFG may play different roles.…”

Section: The Neural Substrates For Atypical Planning Process In Stuttmentioning

confidence: 96%

“…However, it is still unclear what the neural substrates for atypical planning or execution are and how the neural substrates for the two atypical processes interact with each other. Previous brain imaging studies have revealed widely distributed neural differences between stuttering and non-stuttering speakers, such as the the over-activation in the right frontal operculum/anterior insula and the right cerebellum, absent activation in the bilateral auditory areas, and increased or decreased activation in the motor areas and the basal ganglia (Brown et al, 2005;De Nil et al, 2008Fox et al, 2000;Ingham et al, 2000Ingham et al, , 2004Neumann et al, 2003;Wu et al, 1995). However, it is not clear which of the above neural differences are associated with atypical planning, execution, or interface between them.…”

Section: Introductionmentioning

confidence: 99%

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The neural substrates for atypical planning and execution of word production in stuttering

Chen

Ning

et al. 2010

Experimental Neurology

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a b s t r a c t a r t i c l e i n f oUsing an fMRI-based classification approach and the structural equation modeling (SEM) method, this study examined the neural bases of atypical planning and execution processes involved in stuttering. Twelve stuttering speakers and 12 controls were asked to name pictures under different conditions (single-syllable, multi-syllable, or repeated-syllable) in the scanner. The contrasts between conditions provided information about planning and execution processes. The classification analysis showed that, as compared to nonstuttering controls, stuttering speakers' atypical planning of speech was evident in their neural activities in the bilateral inferior frontal gyrus (IFG) and right putamen and their atypical execution of speech was evident in their activations in the right cerebellum and insula, left premotor area (PMA), and angular gyrus (AG). SEM results further revealed two parallel neural circuits-the basal ganglia-IFG/PMA circuit and the cerebellum-PMA circuit-that were involved in atypical planning and execution processes of stuttering, respectively. The AG appeared to be involved in the interface of atypical planning and execution in stuttering. These results are discussed in terms of their implications to the theories about stuttering and to clinical applications.

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Section: Introductionmentioning

confidence: 69%

Section: The Neural Substrates For Atypical Execution Process In Stutmentioning

confidence: 80%

Section: The Neural Substrates For Atypical Planning Process In Stuttmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The neural substrates for atypical planning and execution of word production in stuttering

Chen

Ning

et al. 2010

Experimental Neurology

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“…Our inclusion criteria were that: (1) the studies presented coordinate-based analyses of the data; (2) all or most of the brain was imaged; and (3) overt speech was used as part of the task. Using these criteria, the following stuttering articles had to be excluded: Wu et al [1995] and Van Borsel et al [2003] because neither reported spatial coordinates for brain locations; De Nil et al [2001], because only a fraction of the brain was imaged; and Ingham et al [2000], because only covert speech was employed. As an aside, gender was not a factor in this meta-analysis.…”

Section: Inclusion Criteria For Articlesmentioning

confidence: 99%

Stuttered and fluent speech production: An ALE meta‐analysis of functional neuroimaging studies

Brown¹,

Ingham²,

Ingham³

et al. 2005

Human Brain Mapping

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357

347

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Abstract:This study reports an activation likelihood estimation (ALE) meta-analysis of imaging studies of chronic developmental stuttering in adults. Two parallel meta-analyses were carried out: (1) stuttered production in the stutterers; (2) fluent production in the control subjects. The control subjects' data replicated previous analyses of single-word reading, identifying activation in primary motor cortex, premotor cortex, supplementary motor area, Rolandic operculum, lateral cerebellum, and auditory areas, among others. The stuttering subjects' analysis showed that similar brain areas are involved in stuttered speech as in fluent speech, but with some important differences. Motor areas were over-activated in stuttering, including primary motor cortex, supplementary motor area, cingulate motor area, and cerebellar vermis. Frontal operculum, Rolandic operculum, and anterior insula showed anomalous rightlaterality in stutterers. Auditory activations, due to hearing one's own speech, were essentially undetectable in stutterers. The phenomenon of efference copy is proposed as a unifying account of the pattern activation revealed within this ALE meta-analysis. This provides the basis for a stuttering system model that is testable and should help to advance the understanding and treatment of this disorder. Hum Brain Mapp 25:105-117, 2005.

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Separation of trait and state in stuttering

Connally

Ward

Pliatsikas

et al. 2018

Human Brain Mapping

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Stuttering is a disorder in which the smooth flow of speech is interrupted. People who stutter show structural and functional abnormalities in the speech and motor system. It is unclear whether functional differences reflect general traits of the disorder or are specifically related to the dysfluent speech state. We used a hierarchical approach to separate state and trait effects within stuttering. We collected sparse‐sampled functional MRI during two overt speech tasks (sentence reading and picture description) in 17 people who stutter and 16 fluent controls. Separate analyses identified indicators of: (1) general traits of people who stutter; (2) frequency of dysfluent speech states in subgroups of people who stutter; and (3) the differences between fluent and dysfluent states in people who stutter. We found that reduced activation of left auditory cortex, inferior frontal cortex bilaterally, and medial cerebellum were general traits that distinguished fluent speech in people who stutter from that of controls. The stuttering subgroup with higher frequency of dysfluent states during scanning (n = 9) had reduced activation in the right subcortical grey matter, left temporo‐occipital cortex, the cingulate cortex, and medial parieto‐occipital cortex relative to the subgroup who were more fluent (n = 8). Finally, during dysfluent states relative to fluent ones, there was greater activation of inferior frontal and premotor cortex extending into the frontal operculum, bilaterally. The above differences were seen across both tasks. Subcortical state effects differed according to the task. Overall, our data emphasise the independence of trait and state effects in stuttering.

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Is Overt Stuttered Speech a Prerequisite for the Neural Activations Associated with Chronic Developmental Stuttering?

Cited by 92 publications

References 52 publications

The neural substrates for atypical planning and execution of word production in stuttering

The neural substrates for atypical planning and execution of word production in stuttering

Stuttered and fluent speech production: An ALE meta‐analysis of functional neuroimaging studies

Separation of trait and state in stuttering

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