Is overactive bladder microvasculature disease a component of systemic atheroscleorosis?

Yeniel, Ahmet Özgür; Ergenoğlu, Ahmet Mete; Meseri, Reci; Kısmalı, Erkan; Ari, Anıl; Kavukçu, Gülgün; Aydin, Hikmet Hakan; Ak, Handan; Atay, Sevcan; Mete, İsmail

doi:10.1002/nau.23452

Cited by 19 publications

(19 citation statements)

References 28 publications

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“…Yeniel et al assessed women with OAB vs controls and demonstrated a link between carotid and femoral artery intima-media thickness, OAB severity, and impaired vascular bladder perfusion. 9 Uzun et al carried out a cross-sectional study to investigate carotid artery IMT in patients with LUTS/OAB. 19 AH, diabetes mellitus (DM), and CVD were exclusion criteria.…”

Section: Discussionmentioning

confidence: 99%

“…2 Hypoxia-induced oxidative stress has been related to neural dysfunction and increased collagen content in the bladder wall. 9,10 Inaba et al demonstrated that cardiovascular risk factors are associated with increased intima-media thickness (IMT) of the common carotid artery on vascular ultrasound. 11 Measures of common carotid artery (CCA) subclinical atherosclerosis, such as intima-media thickness (IMT), adventitial diameter (AD), and carotid plaque (CP), are clinically important predictors of future CVD events.…”

Section: Introductionmentioning

confidence: 99%

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<p>Is There a Link Between Carotid Atherosclerosis and Idiopathic Overactive Bladder Among Women with Metabolic Syndrome?</p>

Schimit

Gregório

Averbeck

et al. 2020

RRU

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Purpose: To evaluate the association between increased intima-media thickness (IMT) and atherosclerotic carotid plaque (CP) with idiopathic overactive bladder syndrome (OAB) in women with metabolic syndrome (MetS). Methods: This is a cross-sectional study, which included consecutive women aged 40-75 years with MetS, seeking medical assistance at a reference center between April and December 2016. OAB-V8 questionnaire was used to estimate the prevalence of OAB symptoms, which were defined by a score ≥8 points. All patients underwent bilateral carotid artery ultrasound to assess IMT and CP. Atherosclerosis was defined by the identification of CP during ultrasound, which was diagnosed according to the Mannheim carotid intimamedia thickness and plaque consensus. Results: Forty-five women were prospectively included. Mean age was 60±9.3 years (range 40-75 ys). Eighteen (40%) patients were diagnosed with OAB. IMT in the general population was 0.72 mm (SD = 0.20). Overall prevalence of atherosclerosis, defined by the presence of the carotid artery plaque, was 51%. OAB prevalence among women with atherosclerosis was higher than in those without atherosclerosis (56.52% versus 22.73%), with a prevalence ratio of 2.49 (p=0.04). Additionally, OAB was associated with degree of carotid stenosis (p = 0.029). Conclusion: In this cohort of female patients with MetS, there was an association between carotid atherosclerosis and OAB. Identification of carotid ultrasound abnormalities may lead to refined treatment decision-making among OAB patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Is There a Link Between Carotid Atherosclerosis and Idiopathic Overactive Bladder Among Women with Metabolic Syndrome?</p>

Schimit

Gregório

Averbeck

et al. 2020

RRU

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“…Yeniel et al assessed atherosclerosis indicators and blood perfusion in the bladder necks in women with OAB. They found that the OAB severity correlated with systemic atherosclerosis and impaired vascular perfusion of the urinary bladder [29]. In diabetic mice, Inouye et al found that Evans blue extravasation in bladder vessels, an index of peripheral and neurogenic inflammation, correlated with bladder dysfunction [30].…”

Section: Diabetes and Bladder Inflammationmentioning

confidence: 99%

The Pharmacological Mechanism of Diabetes Mellitus-Associated Overactive Bladder and Its Treatment with Botulinum Toxin A

Wang

Jiang

Kuo

2020

Toxins

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Diabetes mellitus (DM) is an independent risk factor for overactive bladder (OAB). The pathophysiology of DM-associated OAB is multifactorial and time-dependent. Diabetic bladder dysfunction is highly associated with diabetic complications, mainly including diabetic neuropathy and atherosclerosis. Chronic systemic inflammation and bladder urothelial inflammation may contribute to the onset of OAB. Intravesical botulinum toxin A (BoNT-A) injection has proved to be a successful treatment for idiopathic and neurogenic OAB. BoNT-A can inhibit the efferent pathways of the bladder as well as the chronic inflammation and hypersensitivity via the afferent pathways. We conducted a review of the published literature in Pubmed using a combination of two keywords, namely “botulinum toxin A” (BoNT-A) and “overactive bladder”, with or without the additional keywords “detrusor overactivity”, “diabetes mellitus”, “inflammation”, and “urodynamic study”. We also reviewed the experience of our research teams, who have published several studies of the association between DM and OAB. Since limited data support the effectiveness and safety of BoNT-A for treating patients with DM-associated OAB, a comprehensive evaluation of diabetic complications and urodynamic study is needed before treatment. In the future, it is imperative to explore the clinical characteristics and inflammatory biomarkers of diabetes as determining predictors of the treatment efficacy.

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“…Atherosclerosis has been considered to be one of the important factors, and a possible underlying mechanism of OAB and LUTS in men and women . Thus, the involvement of atherosclerosis in the etiology of OAB has recently attracted attention.…”

Section: Introductionmentioning

confidence: 99%

“…Atherosclerosis has been considered to be one of the important factors, and a possible underlying mechanism of OAB and LUTS in men and women. 9 Thus, the involvement of atherosclerosis in the etiology of OAB has recently attracted attention. Consequently, we presumed that atherosclerosis is involved in not only the emergence of OAB symptoms after RARP, but also the chronological changes of lower urinary tract dysfunction after RARP, and that the seriousness of atherosclerosis serves as a marker for predicting protracted OAB symptoms.…”

Section: Introductionmentioning

confidence: 99%

Atherosclerosis as a predictor of transient exacerbation of overactive bladder symptoms after robot‐assisted laparoscopic radical prostatectomy

et al. 2018

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Objectives To assess whether atherosclerosis is involved in the development of overactive bladder and the function of lower urinary tract after robot‐assisted radical prostatectomy. Methods The present cohort consisted of 80 consecutive participants. The preoperative cardio‐ankle vascular index was used to evaluate the presence of atherosclerosis. The present cohort was split into two groups, the atherosclerotic group, whose cardio‐ankle vascular index was ≥9.0, and the control group, whose index was <9.0. The overactive bladder symptom score and lower urinary tract function were compared for 12 months after surgery. Results The total score of the questionnaire was significantly higher at 6 and 9 months after surgery in the atherosclerosis group (P = 0.04, P = 0.03, respectively). Both the urgency and urgency incontinence subscores of the questionnaire showed a parallel tendency to that of the total score after surgery. At 3 months after surgery, there was a significant increase in the prevalence of de novo overactive bladder in the atherosclerosis group (P = 0.04). At 9 and 12 months after surgery, there was a significant decrease of voided volume in the atherosclerotic group (P < 0.01, P = 0.04, respectively). Conclusions Atherosclerosis delays the improvement in both overactive bladder symptoms and storage function postoperatively, and it is involved in the transient increase in the prevalence of de novo overactive bladder. Atherosclerosis might be a predictor of the development of overactive bladder after robot‐assisted radical prostatectomy.

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Is overactive bladder microvasculature disease a component of systemic atheroscleorosis?

Abstract: Decreased perfusion at the bladder neck, the Framingham scores in severe OAB, and the correlation between them suggest that OAB microvascular disease may be a component of systemic atherosclerosis rather than a separate process.

Cited by 19 publications

References 28 publications

<p>Is There a Link Between Carotid Atherosclerosis and Idiopathic Overactive Bladder Among Women with Metabolic Syndrome?</p>

<p>Is There a Link Between Carotid Atherosclerosis and Idiopathic Overactive Bladder Among Women with Metabolic Syndrome?</p>

The Pharmacological Mechanism of Diabetes Mellitus-Associated Overactive Bladder and Its Treatment with Botulinum Toxin A

Atherosclerosis as a predictor of transient exacerbation of overactive bladder symptoms after robot‐assisted laparoscopic radical prostatectomy

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