Is Ovarian Cancer Prevention Currently Still a recommendation of Our Grandparents?

Jammal, Millena Prata; Lima, Cid Almeida de; Murta, Eddie Fernando Cândido; Nomelini, Rosekeila Simões

doi:10.1055/s-0037-1608867

Cited by 9 publications

(12 citation statements)

References 100 publications

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“…Ovarian cancer is one of the malignant tumours of the female reproductive system. Its incidence has risen in recent years . Ovarian cancer is a highly lethal malignancy that is prone to blood and lymph node metastasis and local infiltration and easily develops resistance to chemotherapeutic drugs.…”

Section: Discussionmentioning

confidence: 99%

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Roflumilast enhances cisplatin‐sensitivity and reverses cisplatin‐resistance of ovarian cancer cells via cAMP/PKA/CREB‐FtMt signalling axis

et al. 2018

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Section: Discussionmentioning

confidence: 99%

“…The incidence of ovarian cancer is ranked third in female genital malignant tumours . But the mortality rate of ovarian cancer is ranked first in female genital malignant tumours, which seriously threatens the life and health of women .…”

Section: Introductionmentioning

confidence: 99%

Roflumilast enhances cisplatin‐sensitivity and reverses cisplatin‐resistance of ovarian cancer cells via cAMP/PKA/CREB‐FtMt signalling axis

et al. 2018

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“…Ovarian cancer (OVC) ranks the seventh most common cause of cancer mortality among women with the worst prognosis and high mortality rate ( https://gco.iarc.fr/ ). In addition to family history, the risk factors for OVC include obesity, smoking, alcoholism, late menopause, hormone replacement therapy, early menarche, nulliparity, and mutations in BRCA1/2 (Brett et al 2017 ; Jammal et al 2017 ). Besides this, exposure to EDCs is reported as one of the significant risk factors for OVC (Rachoń 2015 ).…”

Section: Ovarian Cancermentioning

confidence: 99%

A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence

Khan

Correia

Adiga

et al. 2021

Environ Sci Pollut Res

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Bisphenol A [BPA; (CH3)2C(C6H4OH)2] is a synthetic chemical used as a precursor material for the manufacturing of plastics and resins. It gained attention due to its high chances of human exposure and predisposing individuals at extremely low doses to diseases, including cancer. It enters the human body via oral, inhaled, and dermal routes as leach-out products. BPA may be anticipated as a probable human carcinogen. Studies using in vitro cell lines, rodent models, and epidemiological analysis have convincingly shown the increasing susceptibility to cancer at doses below the oral reference dose set by the Environmental Protection Agency for BPA. Furthermore, BPA exerts its toxicological effects at the genetic and epigenetic levels, influencing various cell signaling pathways. The present review summarizes the available data on BPA and its potential impact on cancer and its clinical outcome.

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“… Poole et al (2013) called for identifying modifiable risk factors. Jammal et al (2017) believe that ovarian cancer prevention can be accomplished with clinical approaches.…”

Section: Introductionmentioning

confidence: 99%

Lifestyle and reproductive health: the aetiology of ovarian cancer in Pakistan

et al. 2020

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Ovarian cancer is a fatal gynaecological cancer and eighth most common cancer in women globally. Lifestyle, reproductive and sociodemographic factors are among the influential parameters that may significantly affect the risk of ovarian cancer and its mortality rate. However, the epidemiological investigations have shown that the risk of ovarian cancers associated with these factors is different in varied geographical distributions. Lifestyle and reproductive factors have not been investigated thoroughly across a wide cultural diversity. The objective of this study is to investigate the association of these factors with ovarian cancer in Pakistan. This investigation will focus on the lifestyle effects of fat intake, intake of tea, habitual exercise, use of talc, personal hygiene, habit of holding urine for long time, obesity on ovarian cancer among Pakistani women. Reproductive variables will include age at menarche, natural menopausal age, parity, nulliparity (miscarriages, abortion, stillbirths), infertility, fertility treatment, tubal ligation, oral contraceptive use, and family history of breast or ovarian cancer. Sociodemographic variables will include effect of age, income, education, and geographical location. A case-control study will be conducted in the major cancer hospitals of Pakistan and the patients will also be interviewed. The controls will be recruited outside the hospital. For controls the same age limit and residency requirements will be applied. The information gained from this research will be an important contribution to develop programs for health promotion, with a focus on ovarian cancer prevention and women’s health. The findings could be used for health policies and planning to prevent ovarian cancer. The research will pave the way for a public policy and interventions to reduce the burden of ovarian cancer in Pakistan.

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Is Ovarian Cancer Prevention Currently Still a recommendation of Our Grandparents?

Cited by 9 publications

References 100 publications

Roflumilast enhances cisplatin‐sensitivity and reverses cisplatin‐resistance of ovarian cancer cells via cAMP/PKA/CREB‐FtMt signalling axis

Roflumilast enhances cisplatin‐sensitivity and reverses cisplatin‐resistance of ovarian cancer cells via cAMP/PKA/CREB‐FtMt signalling axis

A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence

Lifestyle and reproductive health: the aetiology of ovarian cancer in Pakistan

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