Is ocular vascularity affected in young migraine patients? A pilot study

Hamamcı, Mehmet; Songur, Murat Serkan; Bayhan, Seray Aslan; Bayhan, Hasan Alı

doi:10.1016/j.jocn.2021.06.045

Cited by 8 publications

(25 citation statements)

References 45 publications

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“…Among the four studies that reported foveal SCP VD in MO patients, only one of them (17) discovered decreased foveal SCP VD in MO patients (MO vs. HC: 21.1 ± 6.7 vs. 24.2 ± 9.6), while the rest (1,18,19) showed no statistical difference. Foveal SCP VD in MA and MO patients was compared in two studies, and both studies indicated no statistical difference (1,17). Parafoveal SCP VD was reported in five studies (1,(17)(18)(19)22), with no statistical differences among MA, MO, and HC.…”

Section: Scpmentioning

confidence: 98%

“…Measurement of FAZ was performed by eight authors (1,17,19,20,22,23,28,29). Six studies (1,17,20,22,23,29) reported FAZ in patients with MA, three of which (1,23,29) showed increased FAZ compared with HC, while the other three (17, 20, 22) reported no significant difference. Among the six studies that reported FAZ in MO patients, only one study (28) stated that FAZ increased in MO patients compared with HC (MA vs. HC: 0.35 ± 0.11 vs. 0.24 ± 0.12), while the remaining five (1,17,19,20,23) showed no significant difference.…”

Section: Fazmentioning

confidence: 99%

“…Three studies (1,17,22) reported foveal SCP VD in patients with MA, two of which (1,17) showed decreased foveal SCP VD in patients with MA compared with HC, while one (22) found no statistical difference (MA vs. HC: 30.93 ± 5.46 vs. 30.21 ± 5.12). Among the four studies that reported foveal SCP VD in MO patients, only one of them (17) discovered decreased foveal SCP VD in MO patients (MO vs. HC: 21.1 ± 6.7 vs. 24.2 ± 9.6), while the rest (1,18,19) showed no statistical difference. Foveal SCP VD in MA and MO patients was compared in two studies, and both studies indicated no statistical difference (1,17).…”

Section: Scpmentioning

confidence: 99%

“…Four studies (1,17,20,23) with 198 (90 MA and 108 MO) participants were included in the meta-analysis. Analysis of the FAZ was significantly larger in the MA group compared with the MA, migraine with aura; MO, migraine without aura; HC, healthy control; WMD, weighted mean difference; CI, confidence interval; †Original WMD and 95% CI; ‡WMD and 95% CI after using the trim and fill method.…”

Section: Ma Vs Momentioning

confidence: 99%

“…Migraine is considered a chronic neurovascular disease, usually characterized by unilateral throbbing pain, moderate to severe, which may last 4–72 h and may be accompanied with stomachache, nausea, and vomiting ( 1 ). With an overall prevalence of 14.7% in the general population (10.7% in men and 18.8% in women), migraine is the third most common disorder in the world for both sexes ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

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Analysis of macular microvasculature with optical coherence tomography angiography for migraine: A systematic review and meta-analysis

Yu²,

Liu³

et al. 2022

Front. Neurol.

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ObjectiveThis study aimed to evaluate the features of macular microvasculature with optical coherence tomography angiography (OCTA) among migraine patients.MethodsWe systematically searched PubMed, Web of Science, Embase, and Cochrane Library for studies that evaluated the macular microvasculature of migraine patients. The weighted mean differences (WMDs) of the foveal avascular zone (FAZ), foveal superficial capillary plexus (SCP) vessel density (VD), parafoveal SCP VD, foveal deep capillary plexus (DCP) VD, and parafoveal DCP VD with 95% confidence intervals (CIs) among migraine with aura (MA) group, migraine without aura (MO) group, and healthy controls (HC) group were analyzed using a random-effect model. P < 0.05 was considered significant in statistical analyses. Publication bias was assessed using funnel plots and statistical tests (Egger's test and Begg's test).ResultsNine studies covering 675 individuals were enrolled in this meta-analysis ultimately. The FAZ of MA patients was not significantly different from HC (WMD = 0.04, 95% CI −0.00 to 0.09). However, the FAZ of MA was significantly larger than that of HC after correction of publication bias by trim and fill method (WMD = 1.03, 95% CI 0.99 to 1.08). The FAZ of MO patients was similar to that of HC (WMD = 0.03, 95% CI −0.00 to 0.07), while smaller than that of MA patients (WMD = 0.05, 95% CI 0.01 to 0.09). VD of the SCP, either in the foveal or parafoveal area, was not significantly different among the three groups. As for DCP, VD in MA patients was lower when compared with HC in the parafovea (WMD = −1.20, 95% CI −1.88 to −0.51).ConclusionsWe found that there was a larger FAZ in MA compared with HC after adjusting for publication bias. The FAZ in MO was not significantly different from that in HC, but significantly lower than that in MA. There was no significant difference in either foveal or parafoveal VD of SCP among MA, MO, and HC participants, while the parafoveal VD of the DCP in MA was lower than that of the HC.

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Section: Scpmentioning

confidence: 98%