Is Obstructive Sleep Apnea (Osa) in Non-Obese Patients a Less Serious Disease Than in Obese Patients?

Ghanem, Ammar; Mahmood, Syed

doi:10.1378/chest.128.4_meetingabstracts.231s-a

Cited by 8 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study showed that nonobese patients with OSA tend to have significantly milder OSA compared with obese patients regarding parameter such as apnea–hyponea index (AHI), which are consistent with previous studies ( P < 0.05). [ 11 12 13 ] There was significantly higher proportion of nonobese patients who maintained their minimum oxygen saturation above 90% as compared with nonobese during sleep study ( P < 0.05), which is in line with other study. [ 14 ] The upper airway soft-tissue enlargement playa an important role in pathogenesis of obese patients with OSA, whereas bony structure discrepancies may be the dominant contributing factors among nonobese patients.…”

Section: Discussionsupporting

confidence: 88%

Comparison of clinical and polysomnographic parameters between obese and nonobese obstructive sleep apnea

Kumar¹,

Deependra

Kanwar

2020

J Family Med Prim Care

View full text Add to dashboard Cite

Introduction: Obstructive sleep apnea (OSA) is one of the most common sleep-disordered breathing characterized by repeated cessation or reduction in airflow during sleep. OSA occurs in both obese and nonobese individual. This study was designed to compare the clinical and polysomnographic data between obese and nonobese patients with OSA. Materials and Methods: This was a retrospective study that included all the patients diagnosed as between November 2013 and December 2014. The patients were classified into nonobese ( n = 23) and obese ( n = 72) groups if their body mass index (BMI) was <27.5 and ≥27.5, respectively. Data were analyzed using Statistical Package for the Social Sciences (SPSS) software program, version 20.0 (SPSS, Chicago, Illinois). A value of P < 0.05 was considered statistically significant. Results: There were 95 patients of OSA, of which 23 (44.4%) were nonobese and 72 (75.78%) were obese with a mean BMI of 24.37 ± 3.09 and 34.27 ± 8.34 kg/m 2 , respectively. Characteristics, such as male predominance, higher BMI, neck circumference, and loud snoring, were significantly higher in obese group ( P < 0.05) as compared to nonobese. Mild OSA (AHI 5-15) was significantly higher in nonobese patients (39.13% vs. 5.55%, P < 0.00001), whereas severe OSA (AHI >30) was higher in obese patients as compared with nonobese (66.66% vs. 30.43%, P = 0.002). When comparing comorbidities, the hypertension was significantly higher in the obese (47.22% vs. 13.04%, P = 0.003) than the nonobese patients. The incidence of diabetes (37.50% vs. 17.39%) and hypothyroidism (16.66% vs. 4.34%) was also higher in obese group as compared with nonobese. No significant difference was found for mean age, racial origin (Asian/African), and ESS score between obese and nonobese patients. Conclusion: Obstructive sleep apnoea is not restricted to only obese individual; rather it also occurs in nonobese. The severity of OSA in nonobese has generally less as compared with obese and its early identification required high index of suspicion.

show abstract

Section: Discussionsupporting

confidence: 88%

Comparison of clinical and polysomnographic parameters between obese and nonobese obstructive sleep apnea

Kumar¹,

Deependra

Kanwar

2020

J Family Med Prim Care

View full text Add to dashboard Cite

show abstract

“…Garg et al [4] reported that nonobese subjects were more likely in habit of taking sedatives for sleeping when compared to obese counterpart, which was in concordance with other study conducted by Ghanem and Mahmood on 102 patients with OSA [51].…”

Section: Causes For Osa In Nonobese Patientssupporting

confidence: 77%

Obstructive Sleep Apnea: Beyond Obesity

Garg¹,

Srivastava²,

Halekote³

2017

Sleep Apnea - Recent Updates

View full text Add to dashboard Cite

Sleep disorders are of growing concern and are a major public health problem. The obstructive sleep apnea (OSA) is the most common among diferent sleep-related breathing disorders (SRBDs). Obesity is a known associated risk factor for the OSA but is not limited to them. OSA is also recognized in nonobese population. The description of OSA in non obese patients in the literature is sparse. The clinical presentation is similar as in obese but has few diferences as far as pathophysiology and polysomnographic features are concerned. The severity of OSA in nonobese has less severe manifestations thus requires early recognition and diferent treatment strategy to prevent mismanagement of these patients.

show abstract

“…[21] The incidence of hypertension was observed to be more in the obese OSA patients than the non-obese patients. This finding has been supported by several cross-sectional, longitudinal, and treatment studies.…”

Section: Discussionmentioning

confidence: 99%

“…The present nonobese subjects were more likely in habit of taking sedatives for sleeping as compared to obese counterpart which is in concordance with study conducted by Ghanem and Mahmood on 102 patients with OSA. [ 21 ] The incidence of hypertension was observed to be more in the obese OSA patients than the non-obese patients. This finding has been supported by several cross-sectional, longitudinal, and treatment studies.…”

Section: Discussionmentioning

confidence: 99%

A comparative study on the clinical and polysomnographic pattern of obstructive sleep apnea among obese and non-obese subjects

Garg¹,

Singh²,

Prasad³

et al. 2012

Ann Thorac Med

View full text Add to dashboard Cite

OBJECTIVE:This study was designed to compare the pattern of obstructive sleep apnea (OSA) among obese and nonobese subjects regarding clinical and polysomnographic data obtained for a polysomnographic study.METHODS:A cross-sectional retrospective descriptive study was conducted by analyzing polysomnographic data in 112 consecutive patients underwent a sleep study at our sleep laboratory from January 2009 to July 2010. Out of them, 81 were diagnosed to have OSA (apnea-hypopnoea Index ≥5). These patients were classified in two groups with body mass index (BMI) < 27.5 kg/m2 as nonobese and BMI≥27.5 kg/m2 as obese. Clinical as well as polysomnographic data were evaluated and compared between the two groups. Patients were also evaluated for other risk factors such as smoking, alcoholism, and use of sedatives. Data were subjected to statistical analysis (χ2-test, P value <0.05 considered to be significant). The Fisher Exact test was applied wherever the expected frequency for a variable was ≤5.RESULTS:Of 81 patients with OSA, 36 (44.4%) were nonobese with a mean BMI of 26.62 ± 2.29 kg/m2 and 45 (55.6%) were obese with a mean BMI of 35.14 ± 3.74 kg/m2. Mean AHI per hour was significantly more in the obese than in the nonobese group (50.09 ± 29.49 vs. 24.36 ± 12.17, P<0.001). The use of one or more sedatives was more in nonobese as compared to obese (58.3% vs. 24.4%, P=0.002). The obese group had significantly higher desaturation and arousal index (P<0.001). The minimal oxygen saturation was lower in the obese than the nonobese group (68.5 ± 13.00 vs. 80.3 ± 7.40, P<0.001) and was well below 90% in both groups. Overall, the OSA in nonobese patients was mild-to-moderate as compared to that of the obese and no significant differences were observed between them as regard to age, gender, mean neck circumference, excessive daytime sleepiness, adenoid or tonsillar enlargement, smoking, and remaining polysomnographic parameters.CONCLUSION:Obstructive sleep apnea can occur in nonobese persons though with less severity as compared to obese leading to a concept that OSA is not restricted to obese persons only and there is a high demand of its awareness regarding evaluation, diagnosis, and management in such individuals.

show abstract

Is Obstructive Sleep Apnea (Osa) in Non-Obese Patients a Less Serious Disease Than in Obese Patients?

Cited by 8 publications

References 0 publications

Comparison of clinical and polysomnographic parameters between obese and nonobese obstructive sleep apnea

Comparison of clinical and polysomnographic parameters between obese and nonobese obstructive sleep apnea

Obstructive Sleep Apnea: Beyond Obesity

A comparative study on the clinical and polysomnographic pattern of obstructive sleep apnea among obese and non-obese subjects

Contact Info

Product

Resources

About