Is neuropilin-1 the neuroimmune initiator of multi-system hyperinflammation in COVID-19?

Saleki, Kiarash; Alijanizadeh, Parsa; Azadmehr, Abbas

doi:10.1016/j.biopha.2023.115558

Cited by 5 publications

(3 citation statements)

References 177 publications

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“…For the future, we suggest design of therapeutics targeting infammatory pathways in COVID-19. Using in silico vaccinology to target key infammatory molecules may be a rapid and promising approach to achieve this goal [29,30].…”

Section: Discussionmentioning

confidence: 99%

Mortality in ICU COVID-19 Patients Is Associated with Neutrophil-to-Lymphocyte Ratio (NLR): Utility of NLR as a Promising Immunohematological Marker

Seyfi,

Azadmehr,

Ezoji

et al. 2023

Interdisciplinary Perspectives on Infectious Diseases

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Background. Achieving a suitable medical laboratory index is very important for the prediction of clinical outcome of COVID-19 patients hospitalized to the intensive care unit (ICU). The correlation between neutrophil-to-lymphocyte ratio (NLR) and unfavorable outcome of COVID-19 patients hospitalized to ICU was the aim of this study. Methods. We evaluated a cross-sectional study of 312 COVID-19 patients who were hospitalized to the ICU (confirmed by PCR and CT-Scan), in Babol city, Mazandaran province. WBC, RBC, lymphocyte, neutrophil, monocyte, platelet count, NLR, C-reactive protein (CRP), ESR, MCV, MHC, and other factors were evaluated. Results. Our findings indicated that all patients aged 56 to 69 years with COVID-19 had a significant difference ( P < 0.05 ) in neu, lymph, PLT count, NLR, ESR, Hb, and CRP. Also, NLR was significantly ( P < 0.05 ) correlated with the death or discharge of the ICU hospitalized patients. The cut-off of NLR was 7.02 and the mean of NLR was 11.3 ± 10.93 and 5.8 ± 7.45 in death and discharge COVID-19 patients hospitalized to ICU, respectively. ROC curve indicated that, for NLR, the area under curve was 0.76. Conclusions. Our findings showed that NLR can be utilized as a clinical laboratory predictive parameter for mortality of COVID-19 patients admitted to ICU.

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Section: Discussionmentioning

confidence: 99%

Mortality in ICU COVID-19 Patients Is Associated with Neutrophil-to-Lymphocyte Ratio (NLR): Utility of NLR as a Promising Immunohematological Marker

Seyfi,

Azadmehr,

Ezoji

et al. 2023

Interdisciplinary Perspectives on Infectious Diseases

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“…4 Thus, hyperinflammation is a major problem in COVID-19 cases. 5 As the pathological damage caused by COVID-19 involves the immune system, any factor that regulates the immune response may likewise regulate the consequences of COVID-19. 6 The pathological features of human severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) remain to be completely discovered; however its immune pathogenesis is known to be related to the feedback imbalance of the immune system.…”

Section: Introductionmentioning

confidence: 99%

Circulating Inflammatory Factor Levels in the Early Phase of COVID-19 are Associated with the Progression of Respiratory Failure: A Single-Center Retrospective Study

Xiang,

Zhang,

Liu

et al. 2023

JIR

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To evaluate the potential relationships between serum interleukin (IL)-2, IL-4, IL-6, IL-10, IL-17, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α levels and occurrence of respiratory failure in patients with early-stage COVID-19 disease. Patients and Methods: We analyzed clinical characteristics, laboratory parameters, and immunoinflammatory markers in 302 patients diagnosed with SARS-CoV-2 infection who required hospitalization at Changshu Hospital of Nantong University. IL-2, IL-4, IL-6, IL-10, IL-17, IFN-γ, and TNF-α levels in the peripheral blood of patients hospitalized five days after disease onset were measured using multiplex bead-based flow fluorescent immunoassay (MBFFI). Results: Patients with respiratory failure had higher serum IL-4 [0 (0, 0.54) pg/mL], 90.28) pg/mL], 11.34) pg/mL], and 12.13) pg/mL] levels than patients without respiratory failure (P=0.042, P<0.0001, P=0.012, and P=0.036, respectively). Serum IL-2, IFN-γ, and TNF-α levels were not significantly different between the two groups. The occurrence of respiratory failure was positively correlated with sex (R=0.122, P=0.034), lactic acid (R=0.193, P=0.007), white blood cell count (R=0.121, P=0.038), erythrocyte distribution width (R=0.131, P=0.024), thyrocalcitonin (R=0.280, P<0.0001), and D-dimer levels (R=0.214, P<0.0001) but negatively correlated with oxygen partial pressure (R=−0.208, P=0.004), oxygen saturation (R=−0.220, P=0.002), lymphocyte count (R=−0.129, P=0.026), and calcium (R=−0.152, P=0.042). Among the immunoinflammatory biomarkers, the occurrence of respiratory failure was positively correlated with IL-4 (R=−0.117, P=0.042), IL-6 (R=0.206, P<0.0001), IL-10 (R=0.145, P=0.012), and IL-17 (R=0.121, P=0.036) levels. Conclusion: Serum levels of pro-inflammatory cytokines IL-6 and IL-17 and anti-inflammatory cytokines IL-4 and IL-10 were significantly elevated in patients with respiratory failure and weakly positively correlated with the occurrence of respiratory failure. Further studies are required to explore these key immune mechanisms to help clinicians better manage acute complications, long-term sequelae, and possible future COVID-19 variants and be flexible in managing future epidemics and similar public health threats.

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“…In addition, NRPs play a major role in the hyperinflammatory injury of the lung, nervous system, kidneys, liver, pancreas, and heart in COVID-19 cases. These effects result from interaction with specific regions of the SARS-CoV2 spike protein, and vascular endothelial growth factor (VEGF) receptors (VEGFR1/2) ( 5 , 6 ), highlighting the role of multi-organ neuroimmunopathological injury in COVID-19.…”

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confidence: 99%

Editorial: Neuroimmune cell signaling in COVID-19

Saleki,

Mojtahedi,

Ulrichs

et al. 2024

Front. Immunol.

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Is neuropilin-1 the neuroimmune initiator of multi-system hyperinflammation in COVID-19?

Cited by 5 publications

References 177 publications

Mortality in ICU COVID-19 Patients Is Associated with Neutrophil-to-Lymphocyte Ratio (NLR): Utility of NLR as a Promising Immunohematological Marker

Mortality in ICU COVID-19 Patients Is Associated with Neutrophil-to-Lymphocyte Ratio (NLR): Utility of NLR as a Promising Immunohematological Marker

Circulating Inflammatory Factor Levels in the Early Phase of COVID-19 are Associated with the Progression of Respiratory Failure: A Single-Center Retrospective Study

Editorial: Neuroimmune cell signaling in COVID-19

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