Is Neuronal Histamine Signaling Involved in Cancer Cachexia? Implications and Perspectives

Zwickl, Hannes; Zwickl-Traxler, Elisabeth; Pecherstorfer, Martin

doi:10.3389/fonc.2019.01409

Cited by 13 publications

(13 citation statements)

References 173 publications

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“…These symptoms are all consistent with histamine signaling. Anosmia, ageusia, and other symptoms relating to cachexia are often reported in both COVID-19 and mast cell degranulation syndrome, and the potential role of histamine signaling in driving the pathophysiology of cachexia has been reviewed 82,83 . As summarized in Figure 11, the distinctive later ndings of abnormal coagulation, involvement of other organ systems and ARDS occur in the second week after the appearance of symptoms.…”

Section: Famotidine Reaches Functionally Relevant Systemic Concentratmentioning

confidence: 99%

COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms

Malone

Tisdall²,

Fremont-Smith

et al. 2020

Preprint

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SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. Currently, there are no pre- or post-exposure prophylactic COVID-19 medical countermeasures. Clinical data suggest that famotidine may mitigate COVID-19 disease, but both mechanism of action and rationale for dose selection remain obscure. We explore several plausible avenues of activity including antiviral and host-mediated actions. We propose that the principal famotidine mechanism of action for COVID-19 involves on-target histamine receptor H2 activity, and that development of clinical COVID-19 involves dysfunctional mast cell activation and histamine release.

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Section: Famotidine Reaches Functionally Relevant Systemic Concentratmentioning

confidence: 99%

COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms

Malone

Tisdall²,

Fremont-Smith

et al. 2020

Preprint

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“…Further supporting evidence of the primary role of histamine in COVID-19 progression include early symptoms such as anosmia, ageusia, skin rashes, neuropsychiatric symptoms, silent hypoxia and cachexia, all of which are consistent with dysfunctional histamine signaling (Becker et al, 2012;Lechien et al, 2020;Zwickl et al, 2019). In Ghana, the most common symptoms include cough, headache, sore throat, myalgia and anorexia (E. Oduro-Mensah, personal communication, August 14, 2020), also linked to elevated histamine levels.…”

Section: Discussionmentioning

confidence: 95%

Hydro ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation

Antwi¹,

Oduro-Mensah²,

Obiri³

et al. 2020

Preprint

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Background: Holarrhena floribunda stem bark has anecdotal use in Ghanaian folk medicine for management of inflammatory conditions. This study was conducted to investigate the in vivo anti-inflammatory activity of the bark extract using models of acute inflammation in male Sprague Dawley rats, C57BL/6 mice and 36 ICR mice. Methods: A 70 % hydro-ethanol extract of the stem bark (HFE) was evaluated at doses of 5–500 mg/kg bw. Local anaphylaxis was modelled by the pinnal cutaneous anaphylactic test. Systemic anaphylaxis or sepsis were modeled by compound 48/80 or lipopolysaccharide, respectively. Clonidine-induced catalepsy was used to investigate effect on histamine signaling. Anti-oedematogenic effect was assessed by induction with carrageenan. Effects on mediators of biphasic acute inflammation were studied using histamine and serotonin (early phase) or prostaglandin E2 (late phase).Results: HFE demonstrated anti-inflammatory and/or anti-oedematogenic activity comparable to standard doses of aspirin and diclofenac (inhibitors of cyclooxygenases-1 and -2), chlorpheniramine (histamine H1-receptor antagonist), dexamethasone (glucocorticoid receptor agonist), granisetron (serotonin receptor antagonist) and sodium cromoglycate (inhibitor of mast cell degranulation). All observed HFE bioactivities increased with dose.Conclusions: The data provide evidence that the extract of H. floribunda stem bark has anti-anaphylactic and anti-oedematogenic effects; by interfering with signalling or metabolism of histamine, serotonin and prostaglandin E2 which mediate progression of inflammation. The anti-inflammatory and antihistaminic activities of HFE may be relevant in the context of management of COVID-19.

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“…These symptoms are all consistent with histamine signaling. Anosmia, ageusia, and other symptoms relating to cachexia are often reported in both COVID-19 and mast cell degranulation syndrome, and the potential role of histamine signaling in driving the pathophysiology of cachexia has been reviewed 81,82 . As summarized in Figure 11, the distinctive later ndings of abnormal coagulation, involvement of other organ systems and ARDS occur in the second week after the appearance of symptoms.…”

Section: Discussionmentioning

confidence: 99%