Is neuroendocrine differentiation useful to discriminate primary sinonasal intestinal-type adenocarcinomas from metastatic colorectal adenocarcinomas?

Projetti, Fabrice; Serrano, É.; Vergez, S.; Bissainthe, Anne-Charlotte; Delisle, Marie–Bernadette; Uro‐Coste, Emmanuelle

doi:10.1136/jclinpath-2014-202463

Cited by 5 publications

(2 citation statements)

References 8 publications

(13 reference statements)

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“…RB1 mutation can lead to p16 overexpression [18], as here. Neuroendocrine differentiation of sITAC as seen here was shown previously [19][20][21].…”

Section: Discussionsupporting

confidence: 85%

Intestinal metaplasia is a precursor lesion for sinonasal intestinal‐type adenocarcinoma: genomic investigation of a case proving this hypothesis

Sjöstedt

Schmidt

Vieira

et al. 2021

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Intestinal metaplasia is a precursor lesion for sinonasal intestinal-type adenocarcinoma: genomic investigation of a case proving this hypothesis Intestinal metaplasia (IM) of the sinonasal mucosa is a putative precursor lesion of sinonasal intestinal-type adenocarcinoma (sITAC), a carcinoma associated with wood dust exposure [1][2][3][4][5]. In this article, we compare genomic alterations in matched IM and sITAC to substantiate this connection.

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“…RB1 mutation can lead to p16 overexpression [18], as here. Neuroendocrine differentiation of sITAC as seen here was shown previously [19][20][21].…”

Section: Discussionsupporting

confidence: 85%

Intestinal metaplasia is a precursor lesion for sinonasal intestinal‐type adenocarcinoma: genomic investigation of a case proving this hypothesis

Sjöstedt

Schmidt

Vieira

et al. 2021

APMIS

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“…The immune phenotype of the ITAC is characterized by positivity for cytokeratins 7 and 20 and for intestinal differentiation markers. In particular, cytokeratin 7 is frequently but not constantly positive, while cytokeratin 20 is positive in almost all cases, together with CDX2 [ 48 , 49 , 50 , 51 , 52 ]. The presence of cytological atypia, high mitotic index, and areas of necrosis are helpful in the distinction of ITAC from either benign lesions, such as mucocele, or non-intestinal type adenocarcinomas with a low grade of histological malignancy.…”

Section: Pathological Classification and Histotypesmentioning

confidence: 99%

Malignant Sinonasal Tumors: Update on Histological and Clinical Management

et al. 2021

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Tumors of nasal cavity and paranasal sinuses (TuNSs) are rare and heterogeneous malignancies, presenting different histological features and clinical behavior. We reviewed the literature about etiology, biology, and clinical features of TuNSs to define pathologic features and possible treatment strategies. From a diagnostic point of view, it is mandatory to have high expertise and perform an immunohistochemical assessment to distinguish between different histotypes. Due to the extreme rarity of these neoplasms, there are no standard and evidence-based therapeutic strategies, lacking prospective and large clinical trials. In fact, most studies are retrospective analyses. Surgery represents the mainstay of treatment of TuNSs for small and localized tumors allowing complete tumor removal. Locally advanced lesions require more demolitive surgery that should be always followed by adjuvant radio- or chemo-radiotherapy. Recurrent/metastatic disease requires palliative chemo- and/or radiotherapy. Many studies emphasize the role of specific genes mutations in the development of TuNSs like mutations in the exons 4–9 of the TP53 gene, in the exon 9 of the PIK3CA gene and in the promoter of the TERT gene. In the near future, this genetic assessment will have new therapeutic implications. Future improvements in the understanding of the etiology, biology, and clinical features of TuNSs are warranted to improve their management.

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