Is Negative Pressure Wound Therapy Effectivefor the Management of Chronic Wounds?

Gray, Mikel; Peirce, Ben

doi:10.1097/00152192-200405000-00002

Cited by 17 publications

(7 citation statements)

References 13 publications

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“…In the second study, McCallon et al (28) determined that diabetic foot wounds under NPWT healed faster than saline moistened gauze dressings (23 days vs. 43 days). Although pooled analysis of these two small trials favours NPWT, this conclusion must be interpreted with caution given small sample size ( n = 34) and potential methodological flaws (29). More recently, Vuerstaek et al (30) demonstrated that NPWT was effective in a sample of chronic leg ulcer patients.…”

Section: – Moisture Balancementioning

confidence: 99%

Vacuum‐assisted closure home care training: a process to link education to improved patient outcomes

Woo

Sibbald

2008

International Wound Journal

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Negative pressure wound therapy (NPWT) applies subatmospheric pressure across the wound bed inducing cellular and molecular changes that are beneficial to wound healing. This healing modality may facilitate tissue debridement, infection/inflammation control, and moisture balance; the key components of the wound bed preparation paradigm. To ensure that scientific evidence is diffused into daily clinical practice, we are proposing a knowledge transfer model that articulates an educational plan for the various levels of professional development. The discussion highlights the challenges and potential solutions to integrate NPWT into a seamless continuum of care including a community-based patient care model.

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Section: – Moisture Balancementioning

confidence: 99%

Vacuum‐assisted closure home care training: a process to link education to improved patient outcomes

Woo

Sibbald

2008

International Wound Journal

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“…Further research has pointed to the stimulatory effect of microstrain on cellular mitogenesis, angiogenesis, and amplification of growth factors [3]. It has also been proposed that healing is accelerated by active evacuation of excess interstitial fluid, lowering of the heightened capillary after-load and a qualitative dilution of contained microcontaminants, bacteria, and proinflammatory cytokines [3,4]. Several studies have successfully demonstrated acceleration of healing with negative pressure and this has led to its large scale clinical application [5].…”

Section: Brief Reportmentioning

confidence: 99%

The Sri Lankan prototype of a negative pressure wound therapy device

2011

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“…Rapid elimination of infections and infection-prone material from the wound is critical in expediting primary wound closure by reconstructive surgery [18], which can be effectively achieved by PI-VSD. The modality also increases blood flow to the wound [22] and promotes the accumulation of leukocytes and fibroblasts in the wound that facilitate the healing process [23]. Moreover, PI-VSD reduces edema and third space fluids, the frequency at which wound dressings require changing (and hence the workload of medical staff), and overall medical costs [15, 16, 24].…”

Section: Introductionmentioning

confidence: 99%

Preoperative irrigation and vacuum sealing drainage with antibiotic-containing drainage fluid of foot and ankle wounds improves outcome of reconstructive skin flap surgery

2019

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ObjectivesBy observing the infection and soft tissue defect on the wound surface of the foot and ankle, this paper attempts to explore the effect of preoperative irrigation and vacuum sealing drainage with antibiotic-containing drainage fluid (abPI-VSD) on the bacterial quantity and the local inflammatory response at the flap, and further to provide a basis for applying this technique before a reconstructive skin flap surgery of foot and ankle wounds.MethodsSeventy-five patients were randomly divided into two groups, and all surgeries were done by one physician. The flap reconstructions were done to 31 cases with the abPI-VSD being used (group A); the flap reconstructions were done to the rest 44 cases after wound cleaning using antibiotic irrigation solution without the use of the abPI-VSD (group B). Quantitative bacteriology was made to group A before and after the use of abPI-VSD; quantitative bacteriology was made to group B before and after wound cleaning. Then, the reconstructive skin flap surgery was done. After the surgeries, the time of local inflammatory response at the flap in both groups were recorded. The measured bacterial quantity was evaluated in logarithm and by t test.ResultsThe bacterial quantity was 3.2 ± 1.9 × 107 cfu/g in group A before the use of abPI-VSD and 2.3 ± 2.0 × 107 in group B (P > 0.05) before debridement. The bacterial quantity was 1.2 ± 2.0 × 104 cfu/g in group A after abPI-VSD and was 2.9 ± 4.0 × 106 in group B after wound cleaning (P < 0.05). The time of postoperative inflammatory response in the flap was 8 ± 2.5 days in group A and 13 ± 3.4 days in group B (P < 0.05).ConclusionsabPI-VSD can distinctly reduce the bacterial quantity on the surface of the wound, provide a good condition of tissue bed for the flap reconstruction, and effectively control the local inflammatory response at the flap and hence improve the survival quality of the flap.

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Is Negative Pressure Wound Therapy Effectivefor the Management of Chronic Wounds?

Cited by 17 publications

References 13 publications

Vacuum‐assisted closure home care training: a process to link education to improved patient outcomes

Vacuum‐assisted closure home care training: a process to link education to improved patient outcomes

The Sri Lankan prototype of a negative pressure wound therapy device

Preoperative irrigation and vacuum sealing drainage with antibiotic-containing drainage fluid of foot and ankle wounds improves outcome of reconstructive skin flap surgery

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