Is Nail Fold Capillaroscopy Useful in Normotensive and Primary Open Angle Glaucoma? A Pilot Study

Božić, Marija; Senćanić, Paraskeva-Hentova; Spahić, Goran; Kontić, D; Markovic, Vujica; Marjanović, Ivan; Stojković, Marija Mostarica; Đorđević-Jocić, Jasmina

doi:10.3109/02713683.2010.512113

Cited by 11 publications

(10 citation statements)

References 20 publications

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“…Gasser and Flammer 14 have examined 30 patients with NTG, 30 patients with POAG, and 30 controls and noted markedly reduced blood velocities in NTG patients, especially after cold exposure. Bozic et al 15 have studied various morphologic features (but not hemorrhages) in NTG (n ¼ 30) versus high tension glaucoma (n ¼ 30) and found more vascular tortuosity in NTG patients. In a case-only analysis, Lee et al 16 have found significant correlation between dilated capillaries and serum matrix metalloproteinase (MMP)-9 levels as well as between avascular zones and serum MMP-9 levels in 25 NTG patients.…”

Section: Discussionmentioning

confidence: 99%

Nailfold Capillary Abnormalities in Primary Open-Angle Glaucoma: A Multisite Study

Pasquale

Hanyuda

Ren

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. There is considerable evidence for systemic vascular dysfunction in primary openangle glaucoma (POAG). We performed nailfold capillary video microscopy to observe directly the nature of nonocular microvasculature abnormalities in POAG. METHODS.We enrolled 199 POAG patients and 124 control subjects from four sites. We used JH-1004 capillaroscopes to perform nailfold capillary video microscopy on the fourth and fifth digits of each subject's nondominant hand. Videos were evaluated for hemorrhages, dilated capillary loops > 50 lm, and avascular zones > 100 lm by graders masked to case status. Multivariable odds ratios (ORs) and 95% confidence intervals (CIs) for POAG were obtained by means of logistic regression analyses that were applied to data from all cases and controls. Corresponding estimates of moderate or severe POAG versus mild POAG (based on the Hodapp-Anderson-Parrish scale) were obtained among cases only. RESULTS.After controlling for demographic factors, family history of glaucoma, systemic diseases, and use of anticoagulation and antiplatelet therapy, for each 100 nailfold capillaries assessed, all types of microvascular abnormalities were significantly associated with POAG. Specifically, the presence of any dilated capillaries (OR ¼ 2.9; 95% CI, 1.6-5.6), avascular zones (OR ¼ 4.4; 95% CI, 1.7-11.3) and hemorrhages (OR ¼ 12.2; 95% CI, 5.9-25.1) were associated with POAG. Among cases, the frequency of microvascular abnormalities was not associated with glaucoma severity (P ‡ 0.43).CONCLUSIONS. These data provided support for nonocular capillary bed abnormalities in POAG. Comparable vascular abnormalities in the optic nerve may render it susceptible to glaucomatous damage.

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Section: Discussionmentioning

confidence: 99%

Nailfold Capillary Abnormalities in Primary Open-Angle Glaucoma: A Multisite Study

Pasquale

Hanyuda

Ren

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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“…Nailfold capillary videomicroscopy is used for diagnostic purposes in rheumatology 19 and has served a role in defining vascular changes in primary open-angle glaucoma (POAG). [20][21][22] Although nailfold capillary hemodynamics in XFS have been assessed, 16 the nailfold capillary morphology in XFS/XFG has never been studied. The nailfold capillary bed shares the same hairpin loop architecture as the iris microvasculature 23,24 and thus may serve as a useful surrogate to gain further insight into the systemic manifestations of XFS/XFG.…”

Section: Introductionmentioning

confidence: 99%

Nailfold capillary morphology in exfoliation syndrome

Cousins

Kang

Bovee

et al. 2017

Eye

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Purpose The purpose of the study was to investigate nailfold microvascular morphology in exfoliation syndrome with or without glaucoma (XFS/XFG) compared with primary open-angle glaucoma (POAG) and control subjects using nailfold capillary videomicroscopy. Patients and methods We used a JH-1004 capillaroscope to perform nailfold capillary videomicroscopy on the fourth and fifth digit of the non-dominant hand. We enrolled 56 XFS/XFG patients, 87 POAG patients, and 75 control subjects. Masked observers graded the videos for hemorrhages, avascular zones ≥ 200 microns (μm), and degree of microvascular tortuosity on a four-point subjective scale. Multivariable odds ratios, 95% confidence intervals and P-for trends for assessing the relation between morphological changes and POAG or XFS/XFG were obtained from logistic regression analyses. We also assessed this relation with XFS/XFG compared with POAG in multivariable models. Results After adjusting for multiple covariates, nailfold hemorrhages, avascular zones ≥ 200 μm, and higher degree of vascular tortuosity were more common in XFS/XFG vs controls (P-for trend ≤ 0.0001) and in POAG vs controls (P-for trend ≤ 0.01). For each 100 capillaries, the number of hemorrhages was similar (P-for trend = 0.91) between XFS/XFG and POAG patients; however, there were more avascular zones per 100 capillaries with borderline significance (P-for trend = 0.04) in the XFS/XFG group. XFS/XFG patients had more tortuosity than POAG patients; specifically, having a tortuosity score ≥ 1.5 was associated with a 4.4-fold increased odds of XFS/XFG (95% confidence interval: 1.5-13.3) relative to a tortuosity score o1.0 (P-for trend = 0.005). Conclusion A high degree of nailfold capillary tortuosity is a distinct non-ocular feature associated with XFS/XFG compared with either POAG or controls.

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“…In the sample examined as a part of the present study, no statistically significant differences in the capillary row density were noted among the XFG, POAG, NC and XFS groups. In their study, Bozic et al [23] also conducted nailfold capillaroscopy using the same method and capillaroscopy protocol as those adopted in the present investigation. However, their sample comprised of patients with POAG and normotensive glaucoma (NTG).…”

Section: Discussionmentioning

confidence: 99%

“…Nailfold capillaroscopy can provide valuable information regarding the state of the vascular system at the capillary level, as well as the microvasculature at the junction of the fingernail and skin. Nailfold capillaroscopy is presently used for diagnostic purposes in rheumatology [20], while assisting in defining vascular changes in POAG and normal-tension glaucoma (NTG) [21,22,23].…”

Section: Introductionmentioning

confidence: 99%

Nailfold capillary morphology and platelet function in patients with exfoliative glaucoma

et al. 2019

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Purpose The purpose of the present study was to evaluate the nailfold capillary morphological features in patients with exfoliative glaucoma (XFG) and compare them with those pertaining to primary open-angle glaucoma (POAG), normal controls and subjects with exfoliation syndrome (XFS). The second purpose was to investigate all parameters related to platelet function on the hemogram, including the platelet count (PLT), the mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in patients with XFG. These parameters were subsequently compared with those belonging to normal controls, POAG and XFS subjects. Methods This case control study involved 152 consecutive patients that were examined at the Glaucoma Department of Clinic for Eye Diseases, Clinical Centre of Serbia, as the referral center for glaucoma in Serbia, between June 2016 and December 2017. Results Regarding capillaroscopic characteristics, statistically significant difference was found in capillary diameter and tortuosity between the XFG and POAG group (p = 0.050 and p = 0.035) and the XFG and NC group (p = 0.003 and p = 0.044), as well as in the distribution of capillary loops and avascular zones between the XFG and NC group (p = 0.014 and p = 0.004). The subjects with XFG had lower PLT values compared to POAG patients (p = 0.022). Conclusions In conclusion, to the best of our knowledge, this study marks the first attempt to evaluate capillary morphology as well as to investigate all parameters related to platelet function on the hemogram, in patients with newly diagnosed XFG. Our findings revealed nailfold capillary morphological vascular changes in XFG patients. The subjects with XFG had lower PLT values and a higher MPV serum parameter compared to normal controls and patients with POAG. Further research in this field should therefore aim to evaluate the consequences of the aforementioned microvascular abnormalities in patients with XFG.

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Is Nail Fold Capillaroscopy Useful in Normotensive and Primary Open Angle Glaucoma? A Pilot Study

Cited by 11 publications

References 20 publications

Nailfold Capillary Abnormalities in Primary Open-Angle Glaucoma: A Multisite Study

Nailfold Capillary Abnormalities in Primary Open-Angle Glaucoma: A Multisite Study

Nailfold capillary morphology in exfoliation syndrome

Nailfold capillary morphology and platelet function in patients with exfoliative glaucoma

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