Is Multiple Sclerosis an Autoimmune Disease?

Wootla, Bharath; Eriguchi, Makoto; Rodriguez, Moses

doi:10.1155/2012/969657

Cited by 71 publications

(59 citation statements)

References 138 publications

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“…Although, the prevalence of psoriasis varies considerably by age group, it is most common in the age group 50-69 [3]. Multiple sclerosis (MS) is an autoimmune medicated, inflammatory disease of the central nervous system, characterized by myelin, and various degrees of axonal loss [4,5]. The etiology of MS remains unclear, but genetic, environmental factors might contribute to the immune-mediated destruction of myelin and axon [6,7].…”

Section: Introductionmentioning

confidence: 99%

Increase Risk of Multiple Sclerosis in Patients with Psoriasis Disease: An Evidence of Observational Studies

et al. 2019

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Background: Psoriasis, a common chronic inflammatory disease, increases the risk of developing multiple sclerosis (MS), but evidence for this outcome is still unclear. However, we performed a meta-analysis of relevant studies to quantify the magnitude of the association between psoriasis and MS. It will help to assess the current state of knowledge, fill the gaps in our existing concern, and make a recommendation for future research. Methods: PubMed, EMBASE, and the bibliographies of articles were searched for studies published between January 1, 1990, and November 1, 2017, which reported on the association between psoriasis and MS. Articles were included if they (1) were published in English, (2) reported patients with psoriasis, and the outcome of interest was MS, (3) provided OR/RR/HR with 95% CI or sufficient information to calculate the 95% CI, and (4) if ≥50 patients. All abstracts, full-text articles, and sources were reviewed, with duplicate data excluded. Summary relative risk (ORs) with 95% CI was pooled using a random-effects model. Subgroup and sensitivity analyses were also conducted. Results: We selected 11 articles out of 785 unique abstracts for full-text review using our predetermined selection criteria, and 9 out of these 11 studies met all of our inclusion criteria. The overall pooled increased of developing MS in patients with psoriasis was RR 1.607 (95% CI 1.322–1.953, p < 0.0001) with low heterogeneity (I² = 37.41%, Q = 12.782, τ² = 0.027) for the random effect model. In the subgroup analysis, the MS risk in the patient with psoriasis was also significantly higher in the 6 studies from Europe RR 1.57 (95% CI 1.26–1.94, p < 0.001) with moderate heterogeneity (I² = 50.66%, Q = 10.13, τ² = 0.03) for the random effect model. Conclusion: Our results showed that psoriasis is significantly associated with an increased risk of developing MS. Physicians should carefully be observed symptoms and empower their patients to improve existing knowledge and quality of life. Further studies are warranted to establish the mechanisms underlying this relationship.

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Section: Introductionmentioning

confidence: 99%

Increase Risk of Multiple Sclerosis in Patients with Psoriasis Disease: An Evidence of Observational Studies

et al. 2019

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“…39 The total charge of the system was neutralized with the addition of fourteen Na + ions. The TIP3P water model 40 was 8 used in the solvation of the system and truncated octahedral periodic boundary conditions were applied to the system with a cutoff distances of 10 Å. The system was minimized over 5000 steps, followed by the gentle heating to 300K over 100 ps, using the Langevin dynamics temperature scaling (time step 2 fs).…”

Section: Molecular Dynamics (Md) Simulation Of the Hmog35-55 Complexementioning

confidence: 99%

“…Introduction complex to activate T-cells is correlated with the strength of its binding affinity with TCR. [6][7][8] Conversely, stimulation or not of T-cells that are responsible for MS follows. [9][10][11][12][13] The HLA class II receptors are dimers comprised of two different polypeptide chains (α and β).…”

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confidence: 99%

Molecular dynamics at the receptor level of immunodominant myelin oligodendrocyte glycoprotein 35–55 epitope implicated in multiple sclerosis

Yannakakis

Tzoupis

Michailidou

et al. 2016

Journal of Molecular Graphics and Modelling

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Multiple Sclerosis (MS) is a common autoimmune disease whereby myelin is destroyed by the immune system. The disease is triggered by the stimulation of encephalitogenic T-cells via the formation of a trimolecular complex between the Human Leukocyte Antigen (HLA), an immunodominant epitope of myelin proteins and T-cell Receptor (TCR). Myelin Oligodendrocyte Glycoprotein (MOG) is located on the external surface of myelin and has been implicated in MS induction. The immunodominant 35-55 epitope of MOG is widely used for in vivo biological evaluation and immunological studies that are related with chronic Experimental Autoimmune Encephalomyelitis (EAE, animal model of MS), inflammatory diseases and MS. In this report, Molecular Dynamics (MD) simulations were used to explore the interactions of MOG35-55 at the receptor level. A detailed mapping of the developed interactions during the creation of the trimolecular complex is reported. This is the first attempt to gain an understanding of the molecular recognition of the MOG35-55 epitope by the HLA and TCR receptors. During the formation of the trimolecular complex, the residues Arg(41) and Arg(46) of MOG35-55 have been confirmed to serve as TCR anchors while Tyr(40) interacts with HLA. The present structural findings indicate that the Arg at positions 41 and 46 is a key residue for the stimulation of the encephalitogenic T-cells.

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“…Multiple sclerosis (MS) is understood to be, at least in part, an autoimmune disease of the central nervous system [1]. The disease causes demyelination, resulting in an array of symptoms, including fatigue, depression, neuromuscular problems, pain, sleep disorders, bowel and bladder problems, vision problems, and sexual dysfunction [2].…”

Section: Introductionmentioning

confidence: 99%

Adoption of Oral Disease-Modifying Treatments for Multiple Sclerosis in Europe and the United States between 2012 and 2015

2016

IJSR

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Is Multiple Sclerosis an Autoimmune Disease?

Cited by 71 publications

References 138 publications

Increase Risk of Multiple Sclerosis in Patients with Psoriasis Disease: An Evidence of Observational Studies

Increase Risk of Multiple Sclerosis in Patients with Psoriasis Disease: An Evidence of Observational Studies

Molecular dynamics at the receptor level of immunodominant myelin oligodendrocyte glycoprotein 35–55 epitope implicated in multiple sclerosis

Adoption of Oral Disease-Modifying Treatments for Multiple Sclerosis in Europe and the United States between 2012 and 2015

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