Is multifocal electroretinography an early predictor of glaucoma?

Golemez, Haydar; Yıldırım, Nilgün; Özer, Ahmet

doi:10.1007/s10633-016-9524-3

Cited by 10 publications

(10 citation statements)

References 34 publications

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“…Gölemez et al measures the sensitivity of mfERG in diagnosis, especially in suspected cases. The authors observed that especially the N2 amplitudes were decreased in the central ring (5 degrees) in the early stage and in all rings in advanced-stage patients compared with the control group [15]. In our study, when the mfERG parameters of the patients were compared between the early and middle-advanced glaucoma groups, there was no significant difference in the amplitudes of the N1-P1-N2 waves and implicit time.…”

Section: Resultscontrasting

confidence: 58%

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Spectral-Domain Optical Coherence Tomography and Multifocal Electroretinography Results in the Long-Term Follow-Up of Glaucoma Patients

Çetinkaya

İnan

Yiğit³

et al. 2020

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Objective: To investigate the changes in macular retinal layers and panretinal neuroretinal functions in the long-term follow-up of patients with primary open-angle glaucoma. Materials and Methods: Forty-one patients diagnosed with primary open-angle glaucoma were followed up for 12 months. According to their mean deviation (MD) values), the patients were put into two groups as Group 1 with early stage glaucoma (MD≥-6) and Group 2 with middle-advanced stage glaucoma (MD<-6). Optical coherence tomography (OCT) and multifocal electroretinography (mfERG) were performed at the baseline and at the sixth- and 12th-month evaluations. The OCT, retinal layer and mfERG findings were compared between the two groups. Results: There was no statistically significant difference between the groups in terms of gender and age In Group 2, the mean baseline macula Retina Nerve Fiber Layer, Ganglion Cell Layer and Inner Pleksiform Layer measurements were lower in each quadrant compared to Group 1. Concerning progression in OCT measurements, there was no significant difference between the two groups. However, it was noteworthy that in Group 2, there was a decrease especially in the first and second ring amplitudes of the P1 and N2 waves and prolongation of the implicit time. At the 12-month evaluation, there was prolongation of the implicit time of the N1 wave and a decrease in the P1 wave amplitude in Group 1. Conclusion: Retinal layers are affected in patients with intermediate and advanced stage glaucoma. In the follow-up of early stage glaucoma patients, mfERG measurements can show damage that may occur.

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Section: Resultscontrasting

confidence: 58%

“…As a potentially effective procedure, mfERG produces the simultaneous records of focal retinal response in many different retinal regions and shows the topographic representations of retinal response components [12,13]. The early detection of retinal dysfunction is recommended for the diagnosis of early stage glaucoma [14,15].…”

Section: Introductionmentioning

confidence: 99%

Spectral-Domain Optical Coherence Tomography and Multifocal Electroretinography Results in the Long-Term Follow-Up of Glaucoma Patients

Çetinkaya

İnan

Yiğit³

et al. 2020

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“…The mfERG is a validated methodology for clinical evaluation of several conditions, including retinitis pigmentosa, hydroxychloroquine toxicity, glaucoma, ocular vascular occlusive disorders [22][23][24][25][26][27] . Reveling subclinical abnormalities of retinal function, mfERG can identify patients at risk of retinal damage progression allowing for early therapeutic interventions [28][29][30][31] .…”

Section: Discussionmentioning

confidence: 99%

Neuroretinal Dysfunction in Patients Affected by Neurofibromatosis Type 1

Moramarco

Lucchino

Mallone

et al. 2021

Preprint

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The aim of the study was to examine neuroretinal function by using the mfERG test in patients with neurofibromatosis type 1 (NF1) without optic pathway gliomas (OPGs). This study was conducted on 35 patients (35 eyes) with NF1 and 30 healthy subjects (30 eyes) for the control group. Each subject underwent a complete ophthalmological examination including multifocal electroretinography (mfERG). 1.5-Tesla magnetic resonance imaging (MRI) scan of the brain was performed in NF1 patients to assess the presence of OPGs. All participants were recruited having a best corrected visual acuity (BCVA) of no less than 20/20 in each eye. The amplitude and implicit time of the P1 wave (first-order Kernel component) were evaluated on mfERG. Data analysis was carried out in the two central degrees and in the four quadrants from two to 25 degrees of visual field. Statistically significant results were obtained for the P1 wave amplitudes in the 4 quadrants in NF1 patients compared to healthy subjects, while the reduction was not significant in the 2 central degrees. A statistically significant difference was observed among the P1 wave amplitudes as recorded in the 4 quadrants within the NF1 group, with lower amplitudes in the nasal quadrants. No differences in the implicit times were recorded in the 4 quadrants and in the 2 central degrees as compared between NF1 patients and controls. The present study demonstrates impaired neuroretinal function in NF1 patients. Altered intracellular signal transduction due to abnormal neurofibromin-mediated cyclic adenosine monophosphate (cAMP) generation, could be involved. Our results suggest a possible use of mfERG as subclinical retinal damage indicator with a potential utility in clinical practice for the follow-up of NF1 patients.

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“…It has been suggested that the mfERG N2 component is analogous to the PhNR of the ff-ERG [Viswanathan S, et al IOVS 2009;50: ARVO E-Abstract 4758], which in turn may share retinal generators with the PERG N95 [38,56]. Thus it is not surprising that the mfERG N2 appears to reflect glaucomatous damage [23,57,58]. Significant reduction of LFC amplitudes in mfERG responses to a more complicated stimulus have also been reported in NHP EG [41], which might reflect a similar underlying functional abnormality.…”

Section: Discussionmentioning

confidence: 99%

Comparing three different modes of electroretinography in experimental glaucoma: diagnostic performance and correlation to structure

et al. 2017

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Purpose To compare diagnostic performance and structure-function correlations of multifocal electroretinogram (mfERG), full-field flash ERG (ff-ERG) photopic negative response (PhNR) and transient pattern-reversal ERG (PERG) in a non-human primate (NHP) model of experimental glaucoma (EG). Methods At baseline and after induction of chronic unilateral IOP elevation, 43 NHP had alternating weekly recordings of retinal nerve fiber layer thickness (RNFLT) by spectral domain OCT (Spectralis) and retinal function by mfERG (7F slow-sequence stimulus, VERIS), ff-ERG (red 0.42 log cd-sec/m2 flashes on blue 30 scotopic cd/m2 background, LKC UTAS-E3000), and PERG (0.8° checks, 99% contrast, 100 cd/m2 mean, 5 reversals/sec, VERIS). All NHP were followed at least until HRT-confirmed optic nerve head posterior deformation, most to later stages. mfERG responses were filtered into low- and high-frequency components (LFC, HFC, >75 Hz). Peak-to-trough amplitudes of LFC features (N1, P1, N2) and HFC RMS amplitudes were measured and ratios calculated for HFC:P1 and N2:P1. ff-ERG parameters included A-wave (at 10 ms), B-wave (trough-to-peak) and PhNR (baseline-to-trough) amplitudes as well as PhNR:B-wave ratio. PERG parameters included P50 and N95 amplitudes as well as N95:P50 ratio and N95 slope. Diagnostic performance of retinal function parameters were compared using the area under the receiver operating characteristic curve (A-ROC) to discriminate between EG and control eyes. Correlations to RNFLT were compared using Steiger’s test. Results Study duration was 15 ± 8 months. At final follow-up, structural damage in EG eyes measured by RNFLT ranged from 9% above baseline (BL) to 58% below BL; 29/43 EG eyes (67%) and 0/43 of the fellow control eyes exhibited significant (>7%) loss of RNFLT from BL. Using raw parameter values, the largest A-ROC findings for mfERG were: HFC (0.82) and HFC:P1 (0.90); for ff-ERG: PhNR (0.90) and PhNR:B-wave (0.88) and for PERG: P50 (0.64) and N95 (0.61). A-ROC increased when data were expressed as % change from BL but the pattern of results persisted. At 95% specificity, the diagnostic sensitivity of mfERG HFC:P1 ratio was best, followed by PhNR and PERG. The correlation to RNFLT was stronger for mfERG HFC (R=0.65) than for PhNR (R=0.59) or PERG N95 (R=0.36), (p=0.20 p=0.0006, respectively). The PhNR flagged a few EG eyes at the final time point that had not been flagged by mfERG HFC or PERG. Conclusions Diagnostic performance and structure-function correlation were strongest for mfERG HFC as compared with ff-ERG PhNR or PERG in NHP EG.

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Is multifocal electroretinography an early predictor of glaucoma?

Cited by 10 publications

References 34 publications

Spectral-Domain Optical Coherence Tomography and Multifocal Electroretinography Results in the Long-Term Follow-Up of Glaucoma Patients

Spectral-Domain Optical Coherence Tomography and Multifocal Electroretinography Results in the Long-Term Follow-Up of Glaucoma Patients

Neuroretinal Dysfunction in Patients Affected by Neurofibromatosis Type 1

Comparing three different modes of electroretinography in experimental glaucoma: diagnostic performance and correlation to structure

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