Is mirex still a contaminant of concern for the North American Great Lakes?

Gandhi, Nilima; Tang, Rex W.K.; Bhavsar, Satyendra P.; Reiner, Eric J.; Morse, David G.; Arhonditsis, George B.; Drouillard, Ken G.; Chen, Tony

doi:10.1016/j.jglr.2015.09.015

Cited by 14 publications

(6 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7 D Rt) were identified by the library as Mirex. Mirex, an OCP, is also used as the flame retardant Dechlorane [51]. Analogues of Dechlorane have been studied in environmental samples under EI conditions.…”

Section: Identification Of Ohcsmentioning

confidence: 99%

Comprehensive two-dimensional gas chromatography coupled to high resolution time-of-flight mass spectrometry for screening of organohalogenated compounds in cat hair

Brits

Gorst-Allman²,

Rohwer

et al. 2018

Journal of Chromatography A

View full text Add to dashboard Cite

The coupling of comprehensive two-dimensional gas chromatography with high-resolution time-of-flight mass spectrometry offers the best separation efficiency combined with accurate mass measurements over a wide mass range. The tremendous power of this screening tool is illustrated by trace qualitative screening analysis of organohalogenated compounds (OHCs) in pet cat hair. Tentative identification was supported by mass spectral database searches and elemental formula prediction from the experimentally determined accurate mass data. This screening approach resulted in the first tentative identification of pentabromoethylbenzene, decabromodiphenyl ethane, hexabromocyclododecane, trisbromoneopentyl alcohol, tris(2-chloroethyl) phosphate and tris(2-chloroisopropyl)phosphate in the South African indoor environment. A total of seventy-two OHCs were identified in the samples and include known flame retardants, such as polybrominated diphenyl ethers, and legacy contaminants such as polychlorinated biphenyls and organochlorine, organophosphorous and pyrethroid pesticides. The results obtained from cat hair indicate that these pets are exposed to complex mixtures of OHCs and the detection of these compounds suggests that non-invasive cat hair samples can be used to model indoor exposure with reference to external deposition of OHCs present in the air and dust surrounding people. Toddlers share the same environment as pet cats and therefore also the same health risks.

show abstract

Section: Identification Of Ohcsmentioning

confidence: 99%

Comprehensive two-dimensional gas chromatography coupled to high resolution time-of-flight mass spectrometry for screening of organohalogenated compounds in cat hair

Brits

Gorst-Allman²,

Rohwer

et al. 2018

Journal of Chromatography A

View full text Add to dashboard Cite

show abstract

“…As such, the assumption of additive toxicity, rather than synergistic or less than additive toxicity, presents a reasonable scenario that also incorporates scientific uncertainty. Our previous work has shown that in the absence of PCBs, mercury, toxaphene, and mirex/photomirex would cause more stringent advisories than they do at present (Bhavsar et al 2011; Gandhi et al 2014, 2015). However, it is not clear if consideration of additive effects of the major contaminants known to exist in Great Lake fish would result in only slightly or substantially more stringent advisories.…”

Section: Introductionmentioning

confidence: 93%

“…Mercury and dioxins/furans are secondary causes of restrictions (Bhavsar et al 2011; OMOECC 2015). Levels of toxaphene and mirex/photomirex only occasionally cause restrictive advisories (Gandhi et al 2014, 2015; OMOECC 2015). Exposures to these and to other major contaminants detected in Great Lakes fish can cause a variety of adverse health impacts in humans (Table 1; Murphy et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Multiple contaminants can generate health effects that are additive, more than additive (synergistic), or less than additive (i.e., some effects are alleviated). Previous studies have highlighted that PCBs and mercury are the two most important contaminants found in Great Lakes fish (Bhavsar et al 2007c, 2011; Gandhi et al 2014, 2015; OMOECC 2015). Although in some cases, the combined effects of PCB and mercury can be less than additive or uncertain, many studies support their additive or synergistic effects (Bemis and Seegal 1999; Fischer et al 2008; Piedrafita et al 2008; Powers et al 2009; Roegge et al 2004).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Are Fish Consumption Advisories for the Great Lakes Adequately Protective against Chemical Mixtures?

Gandhi

Drouillard

Arhonditsis

et al. 2017

Environ Health Perspect

Self Cite

View full text Add to dashboard Cite

Background:The North American Great Lakes are home to > 140 types of fish and are famous for recreational and commercial fishing. However, the presence of toxic substances has resulted in the issuance of fish consumption advisories that are typically based on the most restrictive contaminant.Objectives:We investigated whether these advisories, which typically neglect the existence of a mixture of chemicals and their possible additive adverse effects, are adequately protective of the health of humans consuming fish from the Canadian waters of the Great Lakes.Methods:Using recent fish contaminant monitoring data collected by the government of Ontario, Canada, we simulated advisories using most-restrictive-contaminant (one-chem) and multi-contaminant additive effect (multi-chem) approaches. The advisories from the two simulations were compared to determine if there is any deficiency in the currently issued advisories.Results:Approximately half of the advisories currently issued are potentially not adequately protective. Of the four Great Lakes studied, the highest percentage of advisories affected are in Lake Ontario if an additive effect is considered. Many fish that are popular for consumption, such as walleye, salmon, bass and trout, would have noticeably more stringent advisories.Conclusions:Improvements in the advisories may be needed to ensure that the health of humans consuming fish from the Great Lakes is protected. In this region, total polychlorinated biphenyls (PCBs) and mercury are the major contaminants causing restrictions on consuming fish, whereas dioxins/furans, toxaphene, and mirex/photomirex are of minor concern. Regular monitoring of most organochlorine pesticides and metals in fish can be discontinued.Citation:Gandhi N, Drouillard KG, Arhonditsis GB, Gewurtz SB, Bhavsar SP. 2017. Are fish consumption advisories for the Great Lakes adequately protective against chemical mixtures? Environ Health Perspect 125:586–593; http://dx.doi.org/10.1289/EHP104

show abstract

“…Synthetic polychlorinated biphenyls (PCBs) are chemically stable and have been widely used in the electricity industry, plastics processing industry, chemical industry, and printing industry. PCBs can be discharged into environment through wastes, leakages, and volatilization during the process of production and use, and stable existence, it is involved in surface circulation, and then accumulates in organisms and human bodies through the food chain [1][2]. Only a low dose of PCBs exposure will cause liver damage, nervousl and endocrine disorders, immunosuppression, reproduction abnormality, and infant dysplasia [3][4].…”

Section: Introductionmentioning

confidence: 99%

A Novel PCB77 Electrochemical Sensor Based on Nano-functionalized Electrode and Selected Aptamer

Yao¹,

Chen²,

Chen³

et al. 2020

JNMES

View full text Add to dashboard Cite

3,3'4,4'-tetrachlorobiphenyl (PCB77) is a highly toxic substance that endanger ecological environment and human health. In our study, a novel PCB77 electrochemical sensor based on nano-functionalized electrode and selected aptamer was designed. β-cyclodextrin-Au nanoparticles (β-CD-AuNPs)/Nafion modified glassy carbon electrode (GCE) was used for amplify signal that enable sensitivity advanced, and the selected electroactive ferrocene (Fc) labed aptamer was assembled on the electrode surface via the host-guest recognition between β-CD and Fc. The detection was carried out according to the signal changed caused by transformation in the configuration of aptamer before and after the existence of PCB77. By this strategy, a detection limit down to 1.6×10-8 g/L was achieved. Moreover, it exhibited reliable selectivity against co-existing chemicals.

show abstract

Is mirex still a contaminant of concern for the North American Great Lakes?

Cited by 14 publications

References 55 publications

Comprehensive two-dimensional gas chromatography coupled to high resolution time-of-flight mass spectrometry for screening of organohalogenated compounds in cat hair

Comprehensive two-dimensional gas chromatography coupled to high resolution time-of-flight mass spectrometry for screening of organohalogenated compounds in cat hair

Are Fish Consumption Advisories for the Great Lakes Adequately Protective against Chemical Mixtures?

A Novel PCB77 Electrochemical Sensor Based on Nano-functionalized Electrode and Selected Aptamer

Contact Info

Product

Resources

About