Is Metabolic Syndrome Truly a Risk Factor for Male Lower Urinary Tract Symptoms or Just an Epiphenomenon?

Zamuner, Marina; Laranja, Walker W.; Alonso, Jonas Bodini; Simões, Fabiano A.; Rejowski, Ronald F.; Reis, Leonardo Oliveira

doi:10.1155/2014/203854

Cited by 12 publications

(6 citation statements)

References 22 publications

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“…In the Boston Area Community Health (BACH) Survey, results from 1899 men between the ages of 30 – 79 revealed that men experiencing LUTS had higher odds of metabolic syndrome comorbidity (Kupelian et al, 2013). A study of 490 male patients with metabolic syndrome from a community hospital urologic clinic in Brazil demonstrated a 2-fold increased risk in developing LUTS (Zamuner et al, 2014). Metabolic syndrome correlated with higher IPSS scores and treatment for LUTS, and LUTS severity increased when more components of the syndrome were present in a study of 4666 European men visiting a general practitioner (Pashootan et al, 2015).…”

Section: Causes Of Lutsmentioning

confidence: 99%

Links between lower urinary tract symptoms, intermittent hypoxia and diabetes: Causes or cures?

Abler

Vezina

2018

Respiratory Physiology & Neurobiology

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Bothersome lower urinary tract symptoms (LUTS) manifest as urinary frequency, urgency, incontinence and incomplete bladder emptying. Existing treatments ameliorate but do not eliminate most symptoms, leading to financial and personal burdens attributable to sustained medical therapies that may last a lifetime. The purpose of this review is to highlight evidence of causal associations between LUTS and several common comorbidities, including intermittent hypoxia (IH) concomitant with obstructive sleep apnea (OSA), obesity, metabolic syndrome and type 2 diabetes. Links between these conditions, including therapies targeted to co-occurring complications that have demonstrated benefits for LUTS, suggest compelling avenues of research and also underscore critical gaps in understanding the mechanisms underlying urinary dysfunction. These gaps are prominent in the IH field, where an acknowledged link between OSA and LUTS has gone largely uninvestigated. New tools, models, or reappropriation of existing ones, especially rodent models, is required to parse the associations between IH/OSA, LUTS and obesity/diabetes and to elucidate their underlying, and potentially shared, etiologies.

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Section: Causes Of Lutsmentioning

confidence: 99%

Links between lower urinary tract symptoms, intermittent hypoxia and diabetes: Causes or cures?

Abler

Vezina

2018

Respiratory Physiology & Neurobiology

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“…There is emerging evidence suggesting associations between LUTS and MetS [ 11 ] or its components including obesity [ 12 ], hypertension and diabetes [ 13 ], although results have not been fairly consistent [ 14 , 15 ]. Therefore, it is of our interest to study the LUTS profiles amongst Asian men and improve the understanding of its potential link with MetS components.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Risk Factors and Ethnicity Are Independent Factors Associated with Lower Urinary Tract Symptoms

et al. 2015

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ObjectivesTo determine the lower urinary tract symptoms (LUTS) profile and factors affecting its degree of severity including cardiovascular risk profile, age, ethnicity, education level and prostate volume in a multiethnic Asian setting.Materials and MethodsWe conducted a cross-sectional study of 1021 men aged 40–79 years with no clinical evidence of prostate cancer, prostate surgery or 5α-reductase inhibitor treatment of known prostate conditions. The severity of LUTS was assessed using the International Prostate Symptom Score (IPSS). Potential factors associated with LUTS including age, ethnicity, education, history of hypertension, diabetes and hypercholesterolemia, height, weight, and prostate volume were evaluated using univariable and multivariable analyses.ResultsThere were 506 (50%) men found to have moderate-to-severe LUTS attaining an IPSS above 7. Overall, nocturia (45.5%) was the most frequently reported symptom. Multivariable analysis showed that age, ethnicity, prostate volume and history of hypertension and hypercholesterolemia were independent factors associated with severity of LUTS (p < 0.05). Considering individual lower urinary tract symptoms, we found a strong association of storage symptom with history of hypertension and hypercholesterolemia. Malay men were significantly bothered by post micturition symptom compared to their Chinese and Indian counterparts. Stratified analyses of LUTS demonstrated a mutually exclusive cardiovascular risk factors profile defined by ethnicity.ConclusionSeverity of LUTS varies between different ethnicities across all age groups. In addition to age and prostate volume, ethnicity and cardiovascular risk factors including hypertension and hypercholesterolemia may also need to be taken into account in managing men with LUTS.

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“…Even though PV is associated with LUTS, some studies did not collect data concerning PV. 66,67,83 Most studies defined general obesity as BMI ⩾30 kg/m 2 , while some studies included overweight participants (BMI = 25–29 kg/m 2 ). According to WHO (1999), BMI ⩾25 kg/m 2 indicates overweight and BMI ⩾30 kg/m 2 indicates obesity.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome is associated with prostate enlargement: a systematic review, meta-analysis, and meta-regression on patients with lower urinary tract symptom factors

Omran

Leca

Oštarijaš

et al. 2021

Therapeutic Advances in Endocrinology

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Background: Metabolic syndrome (MetS) is defined by at least three of the following five criteria: blood pressure ⩾130/85 mmHg, fasting blood glucose ⩾5.6 mmol/l, triglycerides concentration ⩾1.7 mmol/l, waist circumference ⩾102 cm (for men), and high-density lipoprotein cholesterol concentration <1.03 mmol/l (for men). MetS has been associated with worse lower urinary tract symptoms (LUTS) and higher International Prostate Symptom questionnaire scores. Materials and Methods: MEDLINE, Cochrane, ClinicalTrials.gov, and SCOPUS were critically appraised for all peer-reviewed manuscripts that suitably fulfilled our protocol’s inclusion criteria established a priori. Meta-analytical and meta-regression calculations were performed in R using the Sidik–Jonkman and Hartung–Knapp random effects model and predefined covariates. Results: A total of 70 studies ( n = 90,206) were included in qualitative synthesis. From these, 60 studies focused on MetS and LUTS: 44 reported positive correlations, 5 reported negative correlations, 11 reported no association, and 10 studies focused on MetS and total prostate volume (TPV). MetS positively correlated with moderate LUTS [odds ratio (OR) = 1.56, 95% confidence interval (CI) = 1.35–1.80], severe LUTS (OR = 2.35, 95% CI = 1.82–3.03), overactive bladder (OAB; OR = 3.2, 95% CI = 1.6–5.8), and nocturia severity (OR = 2.509, 95% CI = 1.571–4.007) at multivariate analysis. A total of 30 studies ( n = 22,206) were included in meta-analysis; MetS was significantly associated with higher TPV (mean differences = 4.4450 ml, 95% CI = 2.0177–6.8723), but no significant predictive factors for effect sizes were discovered. Conclusion: Our meta-analysis demonstrates a significant association between the aggravating effects of MetS, which commonly coexists with obesity and benign prostate enlargement.

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Is Metabolic Syndrome Truly a Risk Factor for Male Lower Urinary Tract Symptoms or Just an Epiphenomenon?

Cited by 12 publications

References 22 publications

Links between lower urinary tract symptoms, intermittent hypoxia and diabetes: Causes or cures?

Links between lower urinary tract symptoms, intermittent hypoxia and diabetes: Causes or cures?

Cardiovascular Risk Factors and Ethnicity Are Independent Factors Associated with Lower Urinary Tract Symptoms

Metabolic syndrome is associated with prostate enlargement: a systematic review, meta-analysis, and meta-regression on patients with lower urinary tract symptom factors

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