Is Metabolic Syndrome A Risk Factor for Colorectal Adenoma?

Kim, Jeong Hwan; Lim, Yun Jeong; Kim, Young‐Ho; Sung, In‐Kyung; Shim, Sang Goon; Oh, Sung-Ook; Park, Sin-Sil; Yang, Sun Young; Son, Hee Jung; Rhee, Poong–Lyul; Kim, Jae J.; Rhee, Jong Chul; Choi, Yoon–Ho

doi:10.1158/1055-9965.epi-07-0199

Cited by 159 publications

(150 citation statements)

References 26 publications

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“…Nine studies were conducted in the USA (16,18,20,32,35,(37)(38)(39)(40) , one in Sweden (42) , five in Korea (6,9,10,22,27) , two in China (23,30) , eight in Japan (8,24,26,28,29,31,36,43) , one in Austria (41) and three in European countries (4,17,34) (Tables 1 and 2). Pooled analysis showed a significant association between serum TAG and CRN (n 29 studies; summary RR = 1·08; 95 % CI 1·05, 1·12, P < 0·00001; Fig.…”

Section: Study Characteristicsmentioning

confidence: 99%

The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis

Tian

Wang

et al. 2015

Public Health Nutr.

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Objective: There have been inconsistent results published regarding the relationship between dyslipidaemia and an increased risk of colorectal neoplasia (CRN), including colorectal adenoma (CRA) and colorectal cancer (CRC). We conducted a meta-analysis to explore the relationship between dyslipidaemia and CRN. Design: We identified studies by performing a literature search using PubMed, EMBASE and the Science Citation Index through October 2013. Setting: We analysed thirty-three independent studies reporting the association between CRN and at least one of the selected lipid components, including total cholesterol (TC), TAG, HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C). Subjects: CRN cases (n 21 809) were identified. Results: Overall, people with high levels of serum TAG (risk ratio (RR) = 1·08; 95 % CI 1·05, 1·12, P < 0·00001) and LDL-C (RR = 1·07; 95 % CI 1·00, 1·14, P = 0·04) presented an increased prevalence of CRN. Subgroup analyses revealed that high levels of serum TC (RR = 1·04; 95 % CI 1·01, 1·09, P = 0·02), TAG (RR = 1·06; 95 % CI 1·03, 1·10, P = 0·0009) and LDL-C (RR = 1·11; 95 % CI 1·04, 1·19, P = 0·003) increased the risk of CRA but not of CRC. No association between serum HDL-C and risk for CRN (including CRA and CRC) was observed. Conclusions: Both TAG and LDL-C were significantly associated with an increasing prevalence of CRN. High levels of serum TC, TAG and LDL-C were positively associated with CRA but not with CRC. No significant association was observed between levels of serum HDL-C and CRN. Keywords Serum lipids Colorectal adenomaColorectal cancer TAG Meta-analysis Colorectal cancer (CRC) is reported to be the fourth most commonly diagnosed cancer and is the second most common cause of cancer deaths in North America (1) . CRC is believed to arise from colorectal adenoma (CRA) through a sequence from adenoma to adenocarcinoma as a consequence of a limited set of molecular events that largely originate with a relatively benign adenoma that progresses to cancer (2) . Accumulated data indicate that metachronous lesions occur at a rate of 20 to 30 % per year in post-polypectomy patients. The propensity to develop CRA identifies a sizeable subgroup of the population at an enhanced risk for subsequent adenoma formation and colorectal carcinoma. This indicates that identifying risk factors associated with CRN is essential for the reduction of colorectal carcinoma.The positive association between obesity and CRA prevalence demonstrates an underlying dose-response relationship according to BMI (3) . Timely screening of obese patients for CRA is thus recommended. Dyslipidaemia is an important component of metabolic syndrome and is demonstrated to contribute to colorectal tumorigenesis through insulin resistance, oxidative stress and inflammatory † The first three authors contributed equally to this work.

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Section: Study Characteristicsmentioning

confidence: 99%

The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis

Tian

Wang

et al. 2015

Public Health Nutr.

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“…None of the three suggested a significant association. Seven (1,5,7,10,12,29,34) found some association between drinking and adenoma (26 (26,39,40) …”

Section: T a B L E 3 Ad J U S T E D Od D S Ra T I O S F O R Co L O mentioning

confidence: 99%

Modifiable Risk Factors for Colorectal Neoplasms and Hyperplastic Polyps

et al. 2009

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“…Показано, что люди с МС и его отдельными компонентами также имеют более высокий риск развития колоректальных аденом, кото-рые более чем в 95% случаев являются предшествен-никами злокачественных новообразований толстой кишки [20,21]. Некоторые компоненты МС более тесно связаны с развитием рака ободочной кишки, чем с раком прямой кишки, также имеются различия в ассоциации МС и его компонентов со злокачествен-ными образованиями толстой кишки в зависимости от пола [19,22,23].…”

Section: ожирение и метаболизмunclassified

“…В корейском исследовании (Kim J.H., et al, 2007) показано, что МС (NCEP ATP III, 2001) ассо-циирован с колоректальными аденомами, это косвенно может свидетельствовать о большей распространен-ности МС и у пациентов с КРР [20]. По данным ис-следования EPIC (Aleksandrova K., et al, 2011), МС встречался у 33,2% пациентов с раком ободочной кишки и у 30% пациентов с раком прямой кишки по критериям NCEP ATP III (2005), а также у 40,6% пациентов с раком ободочной кишки и 35,6% пациен-тов с раком прямой кишки по критериям IDF (2005), что достоверно выше, чем в группе контроля для рака ободочной кишки по обоим критериям и для рака пря-мой кишки по критериям IDF (2005) [19].…”

Section: результатыunclassified

“…По данным Me-Can, значимая ассоциация между повышенным уровнем ТГ и КРР на-блюдалась у мужчин: RR=1,17; 95% CI: 1,06-1,28 [31], О р и г и н а л ь н ы е р а б о т ы в метаанализе высокие квинтили концентрации ТГ против низких были связаны с риском КРР: RR=1,18; 95% CI: 1,04-1,34 [37]. Повышенный уровень ТГ также связан с риском развития колоректальных аде-ном [20,38]. По другим работам, повышенный уровень ТГ сыворотки крови не является предиктором разви-тия КРР [19,11].…”

Section: результатыunclassified

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The metabolic syndrome as a risk factor for colorectal cancer

et al. 2017

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Objective. To evaluate the prognostic significance of metabolic syndrome (MS) in the development of colorectal cancer (CRC) using various MS criteria in Novosibirsk population. Materials and Methods. The study was designed as nested «case-control». Baseline population cohort (9360 men, women aged 45-69) was examined in the HAPIEE project and followed-up during 11 years. The "cases" included all subjects, who had CRC during 11-year follow-up according to the Register of Cancer (n=99, M-52, M-47). The matched control group (2/1) was selected from HAPIEE cohort (n=198, m-104, w-94). The prospective study of CRC was supported by RSF. MS criteria were determined in accordance to VNOK (2009), IDF (2005, NCEP ATP III (2001). Statistical package SPSS v.11.0 was used. Logistic regression was used to estimate the association between MS and risk of CRC. Results. Women with glucose levels ≥6.1 mmol/l had 3 times higher 11-year risk of CRC then those with glucose <6.1 mmol/l (OR=3.11; 95%CI:1. 23-7.87, VNOK, 2009; OR=3.20; 95%CI:1.27-8.08, NCEP ATP III, 2001). Blood pressure (BP) ≥130/85 mmHg was associated with decreased risk of CRC in women and in both sexes, but the relationship became insignificant after controlling for antihypertensive treatment. Other components of the MS were not significantly associated with CRC risk. Conclusions. In studied sample the 11-year risk of developing CRC was significantly increased in women with elevated glucose levels. The negative relationship between elevated BP and the risk of CRC in women and both sexes became insignificant when adjusted for antihypertensive treatment; this finding requires further exploration. Keywords: metabolic syndrome, colorectal cancer, components of the metabolic syndrome, colon and rectum cancer.

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Is Metabolic Syndrome A Risk Factor for Colorectal Adenoma?

Cited by 159 publications

References 26 publications

The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis

The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis

Modifiable Risk Factors for Colorectal Neoplasms and Hyperplastic Polyps

The metabolic syndrome as a risk factor for colorectal cancer

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