Is metabolic dysregulation associated with antidepressant response in depressed women in climacteric treated with individualized homeopathic medicines or fluoxetine? The HOMDEP-MENOP Study

Macías-Cortés, Emma del Carmen; Lopez-Serra, Lidia; Aguilar-Faisal, Leopoldo; Asbún-Bojalil, Juan

doi:10.1016/j.homp.2016.11.002

Cited by 15 publications

(13 citation statements)

References 31 publications

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“…Sanguinarine has also been shown to block angiotensin II in a slow, nearly irreversible and non-competitive manner: thus it probably has implications in blood pressure regulation. 72 Though a high prevalence of obesity, dyslipidemia and insulin resistance in menopausal women has been demonstrated, only the two case reports, 48,54 one observational study 53 and two RCTs 51,52 in homeopathy have evaluated the lipid profile. Pre-clinical studies of homeopathic medicines have shown positive results in this field.…”

Section: Discussionmentioning

confidence: 99%

Menopause is more than Hot Flashes: What is Missing in Homeopathic Research? A Narrative Review

Macías-Cortés

2021

Homeopathy

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Background Menopausal complaints are frequently treated with homeopathy in daily practice worldwide. Recently, vasomotor symptoms have been understood to have implications as predictors of other important and long-term outcomes, causing increased risk of mortality and/or disability. Methods A comprehensive search of the literature was conducted to investigate whether homeopathic treatments for menopausal women with vasomotor symptoms have a positive effect on other important health outcomes associated with menopause, such as cardiovascular disease, neurocognitive impairment, metabolic and mood disorders, or osteoporosis. Results Though observational studies have shown encouraging results in reducing the severity and frequency of hot flashes in women treated with homeopathy, few randomized controlled trials have shown positive results. In most of the studies using homeopathy, the primary outcome is reduction in the frequency and severity of hot flashes, and other menopausal complaints are assessed secondarily as a part of the symptoms evaluated in the menopausal scales. Quality of life improves with homeopathic treatments for hot flashes, but there is scarce evidence of the effect of homeopathy on other health outcomes associated with menopause. Limited evidence exists in the case of menopausal women treated with individualized homeopathy for depression and metabolic disorders. Conclusion A more comprehensive approach for treating menopause in routine homeopathic practice constitutes a valuable opportunity to increase knowledge and high-quality research in this field. Future homeopathic research for menopause should be focused on well-designed, double-blind, placebo-controlled, randomized trials as well as on pragmatic trials to show whether homeopathic treatments for vasomotor symptoms can also improve outcomes that are well-known to increase the risk of mortality and/or disability.

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Section: Discussionmentioning

confidence: 99%

Menopause is more than Hot Flashes: What is Missing in Homeopathic Research? A Narrative Review

Macías-Cortés

2021

Homeopathy

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“…Selective serotonin reuptake inhibitors are antidepressants used for the treatment of anxiety disorders ( 27 ). Fluoxetine, a selective 5-HT reuptake inhibitor, is the most commonly used drug to treat patients with T2DM ( 28 , 29 ).…”

Section: Discussionmentioning

confidence: 99%

Fluoxetine regulates glucose and lipid metabolism via the PI3K‑AKT signaling pathway in diabetic rats

et al. 2020

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“…According to World Health Organization (WHO), depression, which has a lifetime prevalence of more than 15 %, may become the second leading cause of death worldwide after cancer [1]. Climacteric depression is a common mental disorder in women.…”

Section: Introductionmentioning

confidence: 99%

“…The physiological changes which precede mental symptoms aggravate depression, especially in women [3]. The results of clinical studies show that the incidence of climacteric depression accounts for about 6 % of climacteric population and 78 % of climacteric syndrome, and about 80 % of menopausal women usually experience mood disorders [4]. The incidence of suicide is higher in menopausal women than in men of same age [4].…”

Section: Introductionmentioning

confidence: 99%

Effect of polyphenol extract from Zanthoxylum bungeanum Maxim. on endocrine hormones and monoamine oxidase activity in a mouse model of climacteric depression

Song¹,

Zhang²,

You³

et al. 2020

Trop. J. Pharm Res

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Purpose: To investigate the effects of polyphenol extract from Zanthoxylum bungeanum Maxim. (ZPPC) on endocrine hormones, monoamine oxidase activity and behavior in a mouse model of climacteric depression.Methods: Institute of Cancer Research (ICR) female albino mice (n = 50) weighing 24 – 26 g (mean wt = 25.0 ± 1.0 g) were randomly assigned to five groups of ten rats each: normal control group, negative control, and ZPPC (50 mg/kg), ZPPC (100 mg/kg) and ZPPC (200 mg/kg) groups. Depression was induced in the mice via oral administration of moclobemide at a dose of 20 mg/kg, and intraperitoneal injection of imipramine (20 mg/kg) 1 h and 30 min, before treatment. Tail suspension, forced swimming and voluntary activity tests were performed on the mice. The activity of monoamine oxidase (MAO) in mouse brain and the levels of endocrine hormones were also determined.Results: Treatment of depressed mice with ZPPC significantly and dose-dependently increased their tail suspension and immobility time (p < 0.05). The activity of monoamine oxidase in the brains of mice in the negative control group was significantly higher than that of normal control mice, but was significantly and dose-dependently reduced by ZPPC treatment (p < 0.05). Similarly, treatment of depressed mice with ZPPC significantly and dose-dependently reduced their serum adrenocorticotropin and corticosterone levels (p < 0.05).Conclusion: The results of this study indicate that ZPPC exerts antidepressant effect via suppression of brain MAO activity. Keywords: Climacteric depression, Endocrine hormones, Menopause, Monoamine oxidase, Polyphenols

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Is metabolic dysregulation associated with antidepressant response in depressed women in climacteric treated with individualized homeopathic medicines or fluoxetine? The HOMDEP-MENOP Study

Cited by 15 publications

References 31 publications

Menopause is more than Hot Flashes: What is Missing in Homeopathic Research? A Narrative Review

Menopause is more than Hot Flashes: What is Missing in Homeopathic Research? A Narrative Review

Fluoxetine regulates glucose and lipid metabolism via the PI3K‑AKT signaling pathway in diabetic rats

Effect of polyphenol extract from Zanthoxylum bungeanum Maxim. on endocrine hormones and monoamine oxidase activity in a mouse model of climacteric depression

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