Is Mean Platelet Volume Really a Severity Marker for Obstructive Sleep Apnea Syndrome without Comorbidities?

Abstract

Obstructive sleep apnea syndrome (OSAS) is a common disorder that can lead to significant cardiovascular complications. Several studies have reported increased platelet activation and aggregation in patients with OSAS. In this study we aimed to show a correlation between mean platelet volume (MPV) and severity of OSAS in patients with OSAS without any overt cardiac disease or diabetes. The polysomnography recordings of 556 consecutive patients admitted to the sleep laboratory between January 2012 and July 2012 were retrospectively evaluated. The relationship between polysomnographic parameters and biochemical parameters was assessed. Polysomnographic results of 200 patients (154 males [77%]; mean age, 44.5 ± 11.4 years) were included. No correlation was observed between MPV and the average oxygen saturation index, the minimum desaturation index, or the oxygen desaturation index in the study population as well as in severe OSAS group (AHI > 30). The only correlation was found between MPV and AHI in the severe OSAS group (P = 0.010). MPV was not correlated with OSAS severity in patients without any overt cardiac disease or diabetes. These findings raise doubts about the suggestion that MPV might be a marker for OSAS severity, as recommended in earlier studies. Thus, further prospective data are needed.

Platelet indices in obstructive sleep apnea: the role of mean platelet volume, platelet distribution widht and plateletcrit

“…Other indices including MPV and plateletcrit were not different then the control. As mentioned above, there are several studies reporting no difference in MPV between patients with OSA and control (13)(14)(15)(16)(17)(18). The studies reporting difference in MPV, found that MPV was higher only in patients with severe OSA (but not milt-moderate OSA) than the control group (4)(5)(6)(7)9).…”

“…Moreover in some studies, it was proposed that treatment with continuous positive airway pressure (CPAP) devices and surgical intervention significantly reduce MPV and PDW values in patients with severe OSA (10)(11)(12)24). On contrary, almost similar number of study reported no relationship between MPV and OSA, and between PDW and OSA (13)(14)(15)(16)(17)(18).…”

“…Moreover continuous positive airway pressure treatment (CPAP) reported to cause a significant decrease in the MPV and PDW values in patients with OSA (10)(11)(12). On contrary, some other studies reported no relationship between MPV and OSA, and between PDW and OSA (13)(14)(15)(16)(17)(18). Because there are controversies among studies, we aimed to investigate platelet indices in our patients with OSA.…”

The Severity of Obstructive Sleep Apnea Syndrome is related to Red Cell Distribution Width and Hematocrit Values

“…Red cell and platelets indices have been extensively investigated in various diseases. Limited, controversial information is available, however, on the association between red cell [15][16][17][18][19] and platelets [15,[20][21][22][23][24][25] parameters and the severity of OSAS. Therefore, the aim of this study was to investigate the levels of these parameters in patients with OSAS and to assess whether there is any correlation between the severity of OSAS and any of these parameters.…”

The Relationship of Hemogram Parameters and Night Desaturation in Patients Diagnosed with Obstructive Sleep Apnea Syndrome

“…OUAS'de görülen kardiyovasküler komplikasyonları OTH ile öngörülebileceğini söyleyen çalışmaların sonuçları çelişkilidir. Bazı çalışmalarda OUAS'de OTH hacminin arttığı belirtilmekte iken (6,7), bazı çalışmalarda ise OUAS ağırlığı ile OTH arasında ilişki saptanamamıştır (8). Ayrıca OUAS'nin sadece apne ve hipopneler ile seyreden bir solunum olayı olarak algılanmaması gerektiği, enflamasyonun eşlik ettiği sistemik bir hastalık olarak değerlendirilmesi gerektiği düşünülmektedir.…”