Is mean platelet volume associated with the angiographic severity of coronary artery disease?

Ekici, Berkay; Erkan, Aycan Fahri; Alhan, Aslıhan; Sayin, Irmak; Aylı, Meltem; Töre, Hasan Fehmi

doi:10.5603/kp.2013.0195

Cited by 44 publications

(35 citation statements)

References 26 publications

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“…Patients with higher MPV levels had high GS and had more severe and critical lesions concurrently. Additionally, a correlation ( p = 0.010) between platelet count and the severity of CAD was observed in this study, in contrast to previous studies [29,30]. The relationship between elevated MPV, platelet counts and the severity of atherosclerosis might be explained by the increase in the metabolic and enzymatic activation of platelets and the increased secretion of mediators from the hemostatically active and larger platelets.…”

Section: Discussioncontrasting

confidence: 99%

Blood count parameters can predict the severity of coronary artery disease

Uysal

Dağlı

Akgüllü³

et al. 2016

Korean J Intern Med

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Background/AimsBecause of the inflammatory nature of coronary artery disease (CAD), both platelets and white blood cells have been investigated for years. The aim of this study was to investigate the relationships between some prominently hematologic blood count parameters (mean platelet volume [MPV], neutrophil to lymphocyte ratio [NLR]) and the severity of CAD by using Gensini scores.MethodsA total of 194 patients, who had undergone coronary angiography, enrolled in this study. The control group consisted of 42 patients who had normal coronary arteries. Remaining CAD patients were divided into two groups according to their Gensini scores.ResultsNLR and MPV were higher in the severe atherosclerosis group compared with the mild atherosclerosis group (p = 0.007, p = 0.005, respectively). The Gensini score showed significant correlations with NLR (r = 0.20, p = 0.011), MPV (r = 0.23, p = 0.004) and high density lipoprotein cholesterol (r = –0.161, p = 0.047). Using a cut-off level of 2.54, NLR predicted severe atherosclerosis with a sensitivity of 74% and specificity of 53% (area under curve [AUC], 0.627; 95% confidence interval [CI], 0.545 to 0.704; p = 0.004). MPV values above 10.4 predicted severe atherosclerosis with a sensitivity of 39% and specificity of 90% (AUC, 0.631; 95% CI, 0.549 to 0.708; p = 0.003). In the multiple logistic regression analysis, high levels of NLR (odds ratio [OR], 1.450; 95% CI, 1.080 to 1.945; p = 0.013) and MPV (OR, 1.622; 95% CI, 1.147 to 2.295; p = 0.006) were found to be independent predictors of severe atherosclerosis.ConclusionsOur study suggests that both NLR and MPV are predictors of severe atherosclerosis and may be used for the prediction and identification of cardiac risks in CAD patients.

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Section: Discussioncontrasting

confidence: 99%

Blood count parameters can predict the severity of coronary artery disease

Uysal

Dağlı

Akgüllü³

et al. 2016

Korean J Intern Med

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“…MPV is one of the most commonly used hematology tests that measures the size of platelets. A higher MPV is a risk factor for CVD, besides other risk factors [11]. MPV can also be used in determining the severity of CAD and is associated with adverse cardiovascular outcomes in patients with CVD [12,13].…”

Section: Discussionmentioning

confidence: 99%

“…The Gensini score was correlated with age, time on dialysis (both p < 0.001), NLR (p = 0.004), and C-reactive protein levels (p = 0.034) and inversely correlated with left ventricular ejection fraction (p = 0.023). Multivariate regression analysis showed that age (p = 0.001), time on dialysis 1 3 which can be derived from the complete blood count, have been studied as novel markers of the presence and severity of coronary artery disease (CAD) [8][9][10][11][12][13][14][15]. These markers could help to estimate the prognosis of CAD in patients with CVD.…”

Section: Introductionmentioning

confidence: 99%

Hematological parameters can predict the extent of coronary artery disease in patients with end-stage renal disease

Bal

Okyay

et al. 2015

Int Urol Nephrol

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“…Plateletendothelial interactions facilitate the secondary capture of neutrophils and other leukocytes, which stimulates interaction with various immune and endothelial cells (23,24). Elevated MPV reflects increased inflammation in numerous processes, including atherogenesis and sepsis (7,25). In addition, it has been shown that oxidative stress leads to increased MPV levels (26,27).…”

Section: Discussionmentioning

confidence: 99%

Alterations in platelet count and mean platelet volume as predictors of patient outcome in the respiratory intensive care unit

Sezgı

Taylan

Kaya

et al. 2014

Clinical Respiratory J

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Admission PC and MPV levels were not different in the survived and dead groups. But in the survived group, admission WBC, MPV and PDW levels decreased, while PC increased when compared with admission levels. In the dead group, admission MPV and PDW levels increased, while PC decreased with respect to admission levels. The admission mean PC of the dead group was 182 103, which was above the thrombocytopenia limit. The ratio of admission thrombocytopenia was 45.3% in the dead group, which was significantly higher than that of the survived group (13.8%) (P < 0.001) CONCLUSIONS: Increasing MPV and decreasing platelet count may alert intensivists to the worse course of disease in patients who had normal platelet counts at ICU admission. The development of thrombocytopenia may also be essential to assessing the outcome of ICU patients.

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Is mean platelet volume associated with the angiographic severity of coronary artery disease?

Cited by 44 publications

References 26 publications

Blood count parameters can predict the severity of coronary artery disease

Blood count parameters can predict the severity of coronary artery disease

Hematological parameters can predict the extent of coronary artery disease in patients with end-stage renal disease

Alterations in platelet count and mean platelet volume as predictors of patient outcome in the respiratory intensive care unit

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