Is Mean Platelet Volume a Predictive Marker for the Diagnosis of COVID-19 in Children?

Gümüş, Hüseyin; Demir, Abit; Yukkaldiran, Ahmet

doi:10.22541/au.159708697.70680949

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…In this study, While ROC Curve analysis of lymphocyte count did not give significant results, the area under the curve of the MPV was below 0.40, and it was found that CRP (0.74) and LDH (0.70) have highest area under the curve (Table 3; Figure ). While Gumus et al (17) stated that there was a difference in the MPV and lymphocyte count values between the patient and control groups, Seyit et al (18) showed that the sensitivity of LDH and CRP was 60% and 66%, respectively, and similar to the results of our study, they found that there was no difference between the patient and control groups in the MPV. Due to the different results in the literature, regression modeling was performed to include more than one parameter in this study (Table 4).…”

Section: Resultssupporting

confidence: 89%

The Role of Some Parameters in Diagnosis in the Absence of PCR in the Children with COVID-19

Solmaz

Ercan²,

Erat

et al. 2022

Konuralp Tıp Dergisi

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Objective: Infectious diseases cause inflammation in the human body and produce numerical and functional changes in peripheral blood cells. Coronavirus disease-19 (COVID-19) is also an infectious disease diagnosed by the Polymerase Chain Reaction (PCR) test. However, PCR testing may not always be available. The aim of this study is to show the effect of numerical and functional changes in blood parameters on the diagnosis of COVID-19 in children. Methods: In this retrospective study, 296 patients and 286 healthy children were included. Nasopharyngeal swabs were collected. The swabs were analyzed by Real-time PCR. Independent-t/Mann-Whitney-U tests were applied; Receiver Operating Characteristic (ROC) curves and logistic regression modelling were evaluated. Results: Gender and age distributions of the groups were similar (p>0.05). There were significant differences between the two groups in terms of white blood cell (WBC) (p<0.001), neutrophil (p<0.001), thrombocyte (p<0.001), lymphocyte (p<0.001), mean platelet volume (MPV) (p=0.009), lactate dehydrogenase (LDH) (p=0.003), C-reactive protein (CRP) (p<0.001) and aspartate aminotransferase (AST) (p=0.002). It was found in ROC curve analyses, while LDH (p<0.001) and CRP (p<0.001) values were higher in patients, MPV (p=0.03), platelet (p=0.04), and neutrophil (p<0.001) values of them were lower. The best model in logistic regression was the model that included hemoglobin, neutrophil, lymphocyte, thrombocyte, LDH and CRP. Conclusions: Rapid diagnosis of COVID-19 are crucial for public health. PCR, required for definitive diagnosis, may not always be achieved, so easier and cheaper methods are needed. This study supports the diagnosis of COVID-19 in the children in the absence of PCR.

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Section: Resultssupporting

confidence: 89%

The Role of Some Parameters in Diagnosis in the Absence of PCR in the Children with COVID-19

Solmaz

Ercan²,

Erat

et al. 2022

Konuralp Tıp Dergisi

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“…In a study recently reported from Turkey, a group of COVID-19 patients were compared with a healthy population in the pediatric age group. It has been emphasized that those with COVID-19 have higher MPV and lower lymphocyte values compared to the healthy group (21). In our study, MPV was found to be significant in predicting the ICU requirement.…”

Section: Resultssupporting

confidence: 46%

Relationship between mean platelet volume and intensive care unit requirement in COVID-19 patients

Doğanay²

2021

Journal of Health Sciences and Medicine

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Objective: Our primary aim in this study is to examine the relationship between the mean platelet volume (MPV) and the intensive care unit (ICU) requirement in patients with 2019 coronavirus disease . The secondary aim of the study is to investigate the relationship between age and the ICU requirement. Material and Method: This retrospective observational study was conducted with patients who were diagnosed with COVID-19 in the emergency department of a tertiary hospital. The relationship between the ICU requirement and MPV was evaluated using the Mann-Whitney U test. ROC analysis was performed to determine the predictive accuracy of the 8.3 cut-off value of MPV in those younger than 58 years old patients. CHAID analysis was used as the decision tree method in analyzing the data. The relationship between ICU requirement and MPV were evaluated. Results: There were 711 patients included in this study. The median age of the population was 64 (49-76). According to the CHAID analysis, the study population was divided into 2 classes as those who aged 58 years or younger (Younger Group) and those who older than 58 years (Older Group), and the relationship between the 8.3 threshold value of MPV and the ICU requirement was analyzed. For the Younger group, a significant difference was found in terms of ICU requirement based on the 8.3 threshold value of MPV. Conclusion: Advanced age, high MPV and PLT values in COVID-19 patients, are associated with the ICU requirement. The 8.3 threshold value of MPV can be used as one of the parameters determining the ICU requirement in relatively young patients. In the geriatric age group, it is not beneficial to use MPV measurement to assign the ICU requirement. Multi-center studies with a large number of patients are needed to present the strength of the results of our study more clearly.

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“…Thrombocytes play a role in the pathogenesis of infectious diseases. Previous studies have suggested that megakaryocytes may be affected by cytokines such as IL-3, IL-6, and lead to more reactive production of thrombocytes (32). Therefore, MPVLR is expected to be higher in severe inflammation.…”

Section: �Correlation Between Mean Platelet Volume and Other Laborato...mentioning

confidence: 98%

Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome

et al. 2022

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Abstract Objective: Multisystem inflammatory syndrome in children (MIS-C), is a newly recognised life-threatening complication of coronavirus disease 2019 (COVID-19). Early determination of clinical severity of the disease is important for early decision of treatment regimens. The aim of this study is to investigate the severity classification value of a number of hematological parameters, inflammatory markers and biochemical tests in patients with MIS-C during the acute stage and after anti-inflammatory treatment. Material and Methods: In this retrospective case-controlled study, 64 children with MIS-C and 95 healthy age and gender matched children were included. Patients were divided into three clinical severity groups; mild, moderate, and severe. Results: Mean platelet volume (MPV), MPV to lymphocyte ratio (MPVLR), D-dimer, ferritin, interleukin 6 (IL-6) levels were significantly higher, while albumin levels were lower in the severe MIS-C group compared to all the other groups on admission. Neutrophil-to-lymphocyte ratio (NLR) and derived (d) NLR (d-NLR) levels were significantly higher in the moderate group compared to the mild group. In the pre-treatment period of MIS-C patients had higher MPV, platelet distribution width (PDW) values while they had lower white blood cell, lymphocyte, monocyte, haemoglobin, mean corpuscular volume (MCV), red cell distribution width (RDW), plateletcrit and platelet values compared to the post-treatment group. Lymphocyte, platelets, and haemoglobin levels were significantly higher in the control group compared to the pre-treatment group. Acute phase reactants, NLR, NMR, PLR, d-NLR, MPVLR and systemic inflammatory index were significantly higher in all MIS-C patients on admission compared to the control group. Conclusion: Specific routine laboratory test results may be useful in determining disease severity of MIS-C, possibly predict the prognosis and allow early initiation of the appropriate treatment. Keywords: disease severity; haematological parameters; inflammatory markers; Multisystem inflammatory syndrome in children ÖZ Amaç: Çocuklarda multisistem inflamatuar sendrom (MIS-C), coronavirus disease 2019 (COVID-19)’un yeni tanımlanan yaşamı tehdit eden bir komplikasyonudur. Hastalığın klinik şiddetinin erken tespiti, tedavi rejimlerine erken karar verilmesinde önemlidir. Bu çalışmanın amacı, MIS-C'li hastalarda hematolojik parametrelerin, inflamatuar belirteçlerin ve biyokimyasal testlerin hastalığın cidiyetine göre, akut dönemde ve antiinflamatuar tedavi sonrasındaki değerlerini araştırmaktır. Gereç ve Yöntem: Retrospektif vaka kontrollü çalışmaya MIS-C tanısı alan 64 çocuk ve yaş ve cinsiyet uyumlu 95 sağlıklı çocuk dahil edildi. Hastalar klinik bulgulara göre; hafif, orta ve şiddetli olarak üç gruba ayrıldı. Bulgular: Ciddi MIS-C kliniğinde olan hastalarda hastaneye başvuruda ortalama trombosit hacmi (MPV), MPV/lenfosit oranı (MPVLR), D-dimer, ferritin, interlökin 6 (IL-6) seviyeleri anlamlı olarak daha yüksekken, albumin düzeyleri daha düşüktü. Klinik şiddeti orta olan hastalarda hafif olan hastalara göre; Nötrofil-lenfosit oranı (NLR) ve derived NLR (d-NLR) seviyeleri anlamlı olarak daha yüksek saptandı. MIS-C hastalarında tedavi öncesinde tedavi sonrasına göre MPV, trombosit dağılım genişliği (PDW) değerleri daha yüksekken; beyaz küre sayısı, lenfosit, monosit, hemoglobin, ortalama korpüsküler hacim (MCV), kırmızı hücre dağılım genişliği (RDW), plateletcrit ve trombosit değerleri daha düşüktü. Kontrol grubunda, tedavi öncesi gruba göre lenfosit, trombosit ve hemoglobin düzeyleri anlamlı derecede yüksekti.Akut faz reaktanları, NLR, nötrofil monosit oranı, plateler lenfosit oranı, d-NLR, MPVLR ve sistemik inflamatuar indeks, kontrol grubuna kıyasla tüm MIS-C hastalarında başvuru sırasında anlamlı derecede yüksekti. Sonuç: Spesifik rutin laboratuvar test sonuçları, MIS-C'nin hastalık şiddetini belirlemede, prognozu öngörmede, ve uygun tedavinin erken başlatılmasında yararlı olabilir. Anahtar kelimeler: hastalık şiddeti; hematolojik parametreler; inflamatuar belirteçler; çocuklarda multisistem inflamatuar sendrom

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Is Mean Platelet Volume a Predictive Marker for the Diagnosis of COVID-19 in Children?

Cited by 6 publications

References 8 publications

The Role of Some Parameters in Diagnosis in the Absence of PCR in the Children with COVID-19

The Role of Some Parameters in Diagnosis in the Absence of PCR in the Children with COVID-19

Relationship between mean platelet volume and intensive care unit requirement in COVID-19 patients

Hematological Parameters and Inflammatory Markers in Children with Multisystem Inflammatory Syndrome

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