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“…The usage of Mdm2 inhibitors in some cases is significantly limited due to its toxicity in normal cells [29]. Recently, it was reported that the loss of Mdmx induces p53 activation but has much less destructive effects in vivo than Mdm2 inhibition [30]. Therefore, Mdmx remains an interesting and unexplored target of great potential for cancer treatment.…”
Section: Introductionmentioning
confidence: 99%
“…The usage of Mdm2 inhibitors in some cases is significantly limited due to its toxicity in normal cells [29]. Recently, it was reported that the loss of Mdmx induces p53 activation but has much less destructive effects in vivo than Mdm2 inhibition [30]. Therefore, Mdmx remains an interesting and unexplored target of great potential for cancer treatment.…”
Section: Introductionmentioning
confidence: 99%