Is maternal smoking during pregnancy associated with an increased risk of congenital heart defects among offspring? A systematic review and meta-analysis of observational studies

Zhang, Dongyu; Cui, Hao; Zhang, Long; Huang, Yanjie; Zhu, Jun; Xiao-hong, LI

doi:10.1080/14767058.2016.1183640

Cited by 40 publications

(39 citation statements)

References 74 publications

(54 reference statements)

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“…Consanguinity increases the prevalence of rare genetic congenital abnormalities and nearly doubles the risk for neonatal and childhood death . The use of social drugs such as alcohol and maternal exposure to tobacco smoke are also culpable factors of congenital malformation . Finally, over 90% of severe congenital anomalies are found in low and middle‐income countries where pregnant women often lack access to adequate and quality food…”

Section: Introductionmentioning

confidence: 99%

“…1,2 The use of social drugs such as alcohol and maternal exposure to tobacco smoke are also culpable factors of congenital malformation. 22,23 Finally, over 90% of severe congenital anomalies are found in low and middle-income countries where pregnant women often lack access to adequate and quality food. 1,2 Some of the public health measures recommended by the WHO to decrease the frequency of certain birth defects include adequate dietary intake of vitamins and minerals, particularly folic acid in adolescent girls and mothers, preventing maternal exposure to harmful substances, adequate prenatal vaccination, rational prescribing in pregnancy, amongst others.…”

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confidence: 99%

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Drug‐related teratogenic and pathologic causes of birth defects in a tertiary hospital in Southwestern Nigeria

Offor

Awodele

Oshikoya

2019

Pharmacology Res & Perspec

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Birth defects are important causes of neonatal morbidity and mortality. A good understanding of the etiology is a vital step toward developing improved treatment and preventive strategies. We conducted an audit of medical records of newborns with birth abnormalities in a tertiary hospital over a 10‐year period, using a Pro forma designed to collect information on obstetric history, antenatal history, sociodemographics of parents, and the type of birth abnormality. Of the 180 medical records reviewed, female babies were 92 (51.1%) and male babies were 86 (47.8%). The mean age of the fathers was 38.2 + 6.2, and mothers 31.8 + 4.9. Majority 115 (63.9%) of the mothers had records of acute illnesses, and 23 (12.8%) chronic illnesses during pregnancy. Unspecified febrile illness 44 (38.3%), malaria 40 (34.8%), typhoid 8 (6.9%), hypertension 13 (56.5%), pregestational diabetes 4 (17.4%), and HIV 3 (13.0%) were the commonest maternal pathologies. Most of the documented birth abnormalities were Down's syndrome 34 (15.2%); congenital hydrocephalus 32 (14.3%); acyanotic congenital heart defect 30 (13.4%); deformity of the digits 26 (11.6%); and ventricular septal defect 20 (8.9%). The prevalence of maternal pathologies calls for concern, as these may be implicated in birth defects, therefore should be further investigated in future studies.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Drug‐related teratogenic and pathologic causes of birth defects in a tertiary hospital in Southwestern Nigeria

Offor

Awodele

Oshikoya

2019

Pharmacology Res & Perspec

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“…According to a survey, the risk of cleft palate increases by maternal smoking during pregnancy (12), while smoking exposure increases the risk of cleft lip and palate (13). The correlation between maternal smoking and heart failure has been reported in another study; they also reported about 10% relative increase in the risk of suffering congenital heart defects (14). In another survey, maternal smoking was found to be associated with an almost 3 times increased risk of congenital heart defects (OR 2.80; 95% CI 1.76 -4.47) (15).…”

Section: Discussionmentioning

confidence: 83%

Addiction Among Mothers Referring to Medico-Legal Centers in Fars for Legal Abortion due to Fetal Causes: A Seven- Year Review

2017

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Background: Substance abuse results in multiple complications for both the mother and the fetus during pregnancy. Objectives: The present study aimed at evaluating the frequency of mothers' addiction in legal abortion with fetal causes in Fars forensic centers. Methods: This was a descriptive-analytical study with a sample size of 1664. The data including demographic characteristics, obstetric variables, and causes of fetal abortion were recorded. The data were analyzed by SPSS16, using analysis of the mean, median, and chi square test. Results: The rate of addiction was reported to be 40.7% in the study population. This study estimated the prevalence of cigarette smoking, drugs, alcohol and other chemical substances as 31.9%, 5.9%, and 2.9%, respectively. Mother addiction had a significant

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“…Nicotine, the potent stimulant present in tobacco, is a neuroteratogen and it is believed to be the most likely cause of cognitive impairment seen in children of smokers (Rogers, 2008). Epidemiologic studies have reported a positive association between maternal smoking during pregnancy and the risk of CHDs (Lee and Lupo, 2013;Sullivan et al, 2015;Zhang et al, 2016). The highest risk was associated with septal and conotruncal defects (Alverson et al, 2011;Lee and Lupo, 2013).…”

Section: Congenital Anomalies Associated With Prenatal Cigarette Smokmentioning

confidence: 99%

“…The highest risk was associated with septal and conotruncal defects (Alverson et al, 2011;Lee and Lupo, 2013). Doseresponse analysis showed increased risk of septal defects, particularly atrial septal defect and ventricular septal defect, with higher maternal cigarette consumption during pregnancy (Alverson et al, 2011;Lee and Lupo, 2013;Zhang et al, 2016). Genetics appears to influence the susceptibility of offspring to maternal smoking-induced CHDs (Tang et al, 2015).…”

Section: Congenital Anomalies Associated With Prenatal Cigarette Smokmentioning

confidence: 99%

Common congenital anomalies: Environmental causes and prevention with folic acid containing multivitamins

Sarmah

Muralidharan

Marrs

2016

Birth Defects Research Pt C

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Congenital anomalies, congenital defects, or birth defects are significant causes of death in infants. The most common congenital defects are congenital heart defects (CHDs) and neural tube defects (NTDs). Defects induced by genetic mutations, environmental exposure to toxins, or a combination of these effects can result in congenital malformations, leading to infant death or long-term disabilities. These defects produce significant mortality and morbidity in the affected individuals, and families are affected emotional and financially. Also, society is impacted on many levels. Congenital anomalies may be reduced by dietary supplements of folic acid and other vitamins. Here, we review the evidence for specific roles of toxins (alcohol, cigarette smoke) in causing common severe congenital anomalies like CHDs, NTDs, and ocular defects. We also review the evidence for beneficial effects for dietary supplementation, and highlight gaps in our knowledge, where research may contribute to additional benefits of intervention that can reduce birth defects. Extensive discussion of common severe congenital anomalies (CHDs, NTDs, and ocular defects) illustrates the effects of diet on the frequency and severity of these defects. Birth Defects Research (Part C) 108:274-286, 2016. © 2016 Wiley Periodicals, Inc.

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Is maternal smoking during pregnancy associated with an increased risk of congenital heart defects among offspring? A systematic review and meta-analysis of observational studies

Abstract: Our study presents evidence to support the cardiovascular teratogenic effect of maternal smoking during pregnancy, and their offspring may suffer from approximately a 10% relative increase in the risk of CHDs on average.

Cited by 40 publications

References 74 publications

Drug‐related teratogenic and pathologic causes of birth defects in a tertiary hospital in Southwestern Nigeria

Drug‐related teratogenic and pathologic causes of birth defects in a tertiary hospital in Southwestern Nigeria

Addiction Among Mothers Referring to Medico-Legal Centers in Fars for Legal Abortion due to Fetal Causes: A Seven- Year Review

Common congenital anomalies: Environmental causes and prevention with folic acid containing multivitamins

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