Is male fertility associated with type 2 diabetes mellitus?

Bener, Abdülbari; Al‐Ansari, Abdulla; Zirie, Mahmoud; Al-Hamaq, Abdulla O.A.A.

doi:10.1007/s11255-009-9565-6

Cited by 107 publications

(80 citation statements)

References 17 publications

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“…Biometric spot evaluation included calculation of a measure which, because of its close relation to the ANOVA effect size parameter, is referred to as "Effect Size Measure" (ESM). ESM values were calculated according to equation (1) …”

Section: Methodsmentioning

confidence: 99%

“…Comparative proteomic studies employing difference gel electrophoresis (DIGE) 1 indicated an accumulation of modified forms of the eppin (epididymal proteinase inhibitor) protein complex (EPC) components semenogelin-1, clusterin, and lactotransferrin in the sperm proteomes of the above disease groups. The established proteomic approach seems appropriate to identify disease-associated marker proteins and is expected to function as a general noninvasive tool in the analysis of molecular mechanisms causing male infertility as well as in the evaluation of fertilityrestoring treatment strategies.…”

Section: Sermentioning

confidence: 99%

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Identification of Increased Amounts of Eppin Protein Complex Components in Sperm Cells of Diabetic and Obese Individuals by Difference Gel Electrophoresis

Paasch

Heidenreich

Pursche

et al. 2011

Molecular & Cellular Proteomics

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Metabolic disorders like diabetes mellitus and obesity may compromise the fertility of men and women. To unveil disease-associated proteomic changes potentially affecting male fertility, the proteomes of sperm cells from type-1 diabetic, type-2 diabetic, non-diabetic obese and clinically healthy individuals were comparatively analyzed by difference gel electrophoresis. The adaptation of a general protein extraction procedure to the solubilization of proteins from sperm cells allowed for the resolution of 3187 fluorescent spots in the difference gel electrophoresis image of the master gel, which contained the entirety of solubilized sperm proteins. Comparison of the pathological and reference proteomes by applying an average abundance ratio setting of 1.6 and a p < 0.05 criterion resulted in the identification of 79 fluorescent spots containing proteins that were present at significantly changed levels in the sperm cells. Biometric evaluation of the fluorescence data followed by mass spectrometric protein identification revealed altered levels of 12, 71, and 13 protein species in the proteomes of the type-1 diabetic, type-2 diabetic, and non-diabetic obese patients, respectively, with considerably enhanced amounts of the same set of one molecular form of semenogelin-1, one form of clusterin, and two forms of lactotransferrin in each group of pathologic samples. Remarkably, ␤-galactosidase-1-like protein was the only protein that was detected at decreased levels in all three pathologic situations. The former three proteins are part of the eppin (epididymal proteinase inhibitor) protein complex, which is thought to fulfill fertilization-related functions, such as ejaculate sperm protection, motility regulation and gain of competence for acrosome reaction, whereas the putative role of the latter protein to function as a glycosyl hydrolase during sperm maturation remains to be explored at the protein/enzyme level. The strikingly similar differences detected in the three groups of pathological sperm proteomes reflect a disease-associated enhanced formation of predominantly proteolytically modified forms of three eppin protein complex components, possibly as a response to enduring hyperglycemia and enhanced oxidative stress. Male fertility is compromised by the hormonal and metabolic changes that are associated with type-1 and type-2 diabetes (1, 2), obesity (3), and the metabolic syndrome, the latter disturbance sharing essential pathologic features with the former diseases (4). The deleterious influence of diabetes and obesity on fertility is receiving increasing attention because their prevalence and incidence is escalating worldwide, whereas the age at first diagnosis of both diseases is continuously declining (5, 6). Because of this situation, the fertility of a growing number of individuals is affected before and during their reproductive years (7,8). Recently, it was shown in a large cohort study that BMI affects fertility potential at the critical age for reproduction, whereas age had a more dominant effect on ...

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Section: Methodsmentioning

confidence: 99%

Section: Sermentioning

confidence: 99%

Identification of Increased Amounts of Eppin Protein Complex Components in Sperm Cells of Diabetic and Obese Individuals by Difference Gel Electrophoresis

Paasch

Heidenreich

Pursche

et al. 2011

Molecular & Cellular Proteomics

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“…between diabetes mellitus and obesity ratio in infertile men increases proportionally [21]. In seminal plasma of overweight and obese men adiponectin, progranulin and alpha-glucosidase levels are lower and fructose levels are higher than in men with normal weight.…”

Section: Discussionmentioning

confidence: 93%

Markers of accessory glands and seminal parameters in infertile men with overweight and obesity

Lozano-Hernndez¹,

Gualdrón²,

Camejo³

et al. 2017

J Metabolic Synd

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“…This lack is of particular relevance given the increasing interest in the negative impact of DM on sperm parameters, and consequently on male reproductive function (Bener et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Seminal Vesicles and Diabetic Neuropathy: Ultrasound Evaluation

Vignera

Condorelli

Mauro

et al. 2010

Journal of Andrology

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The aim of the study was to evaluate the ultrasound characteristics of the seminal vesicles (SV) of infertile patients with diabetes and neuropathy, and possible changes in relation to duration of diabetes. Sixty infertile patients with type 2 diabetes and symptomatic neuropathy were selected. Patients were divided into 3 groups according to duration of diabetes (group A #5 years, group B between 5 and 15 years, and group C $15 years). A pathological control group of 20 infertile patients without diabetes and a real control group of 20 healthy fertile men were selected and compared. Patients underwent prostate-vesicular transrectal ultrasonography and sperm analysis. The following ultrasound parameters were recorded: 1) body anteroposterior diameter (APD); 2) fundus APD; 3) parietal thickness of the right and left SVs; 4) number of polycyclic areas within both SVs; 5) fundus-to-body ratio; 6) difference of the parietal thickness between the right and the left SVs; and 7) pre-ejaculatory and postejaculatory APD difference. All patients with diabetes had a significantly (P , .05) higher fundus-tobody ratio compared with controls. Group C had a significantly (P , .05) higher fundus-to-body ratio compared with other diabetes groups. There was no significant difference (P . .05) relative to the number of polycyclic areas in patients with diabetes and controls. All patients with diabetes had a significantly lower (P , .05) preejaculatory and postejaculatory difference in body SV APD compared with controls. Group A and group B had a similar preejaculatory and postejaculatory difference in body SV APD, whereas this difference was significantly (P , .05) lower in group C. In conclusion, infertile patients with diabetes and neuropathy have peculiar SV ultrasound features suggestive of functional atony, and duration of disease is associated with worse changes in ultrasound findings.

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Is male fertility associated with type 2 diabetes mellitus?

Cited by 107 publications

References 17 publications

Identification of Increased Amounts of Eppin Protein Complex Components in Sperm Cells of Diabetic and Obese Individuals by Difference Gel Electrophoresis

Identification of Increased Amounts of Eppin Protein Complex Components in Sperm Cells of Diabetic and Obese Individuals by Difference Gel Electrophoresis

Markers of accessory glands and seminal parameters in infertile men with overweight and obesity

Seminal Vesicles and Diabetic Neuropathy: Ultrasound Evaluation

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