Is Lysergic-Acid Diethylamide a Teratogen ?

Zellweger, H; Mcdonald, JohnS.; Abbo, G

doi:10.1016/s0140-6736(67)90339-x

Cited by 80 publications

(8 citation statements)

References 17 publications

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“…Although birth defects in man attributed to LSD have been reported [36], this observation must be interpreted with extreme caution. Considering the relatively high frequency of spontaneous birth defects in the normal population, occurrence of malformed children may indeed be entirely coincidental with ingestion of LSD by the mother.…”

Section: Discussionmentioning

confidence: 84%

“…Several groups of investigators have observed increased chromosomal breakage in cells from LSD users [11,15,20,36], while others have.been unable to confirm these findings [5,24,33]. Several possible explanations for these discrepancies exist because of obvious variables in the populations studied.…”

Section: Discussionmentioning

confidence: 97%

“…21]. Additionally, an increase in chromosomal breakage in peripheral leukocytes of users of LSD has also Materials and Methods been observed by several investigators [11,15,20,36]. During these studies, preliminary evidence of trans-The mother-child pairs, both of the subject and of the placental passage suggested that chromosomal damage control groups, were volunteers from a middle class background and all had completed varying levels of college education.…”

Section: Introductionmentioning

confidence: 93%

“…to the developing human fetus might be observed following maternal ingestion of LSD during pregnancy The ability of the hallucinogen, lysergic acid diethyl- [11,15,36]. Therefore, additional children exposed to amide , to induce chromosomal damage in LSD during various times of gestation were investihuman leukocytes has been demonstrated in vitro [10, gated.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of LSD-25 on the Chromosomes of Children Exposed in Utero

et al. 1968

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ExtractThis paper reports the cytogenetic investigation of nine children exposed to LSD-25 ,in utero, four children of'other LSD users not exposed in utero, the mothers of these children, and six additional adults taking the drug. In comparison with matched controls, significantly elevated frequencies of chromosomal damage were observed in all the individuals exposed. The frequencies of aberrations, however, were markedly reduced in those children not exposed in utero. Eight structural rearrangements were observed, six dicentric chromosomes and two quadriradial formations, among those individuals exposed to the drug, but none was observed in the controls. In spite of obvious chromosomal aberrations, all of the individuals in this study were apparently healthy and showed no obvious birth defects. Speculation

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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The Effect of LSD-25 on the Chromosomes of Children Exposed in Utero

et al. 1968

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“…Cohen et al (1967) reported a high frequency of chromosome breaks in 2 of 4 newborns of mothers taking LSD. These babies did not have recognizable malformations; however, Zellweger, McDonald, and Abbo (1967) reported a case of unilateral fibular aplastic syndrome in a child of parents taking LSD. Father, mother, and child showed an increased incidence of chromatid breaks.…”

Section: Methodsmentioning

confidence: 90%