Is &lt;i&gt;Lactobacillus rhamnosus&lt;/i&gt; GG Effective in Preventing the Onset of Antibiotic-Associated Diarrhoea: A Systematic Review

Hawrelak, Jason; Whitten, Dawn; Myers, Stephen P

doi:10.1159/000087637

Cited by 77 publications

(45 citation statements)

References 41 publications

(33 reference statements)

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“…[45][46][47][48] Treatment with a probiotic was started when antibiotic therapy was initiated for treatment of an acute respiratory infection (otitis media) in most of these studies. Treatment with probiotics compared with placebo reduced the risk of developing antibiotic-associated diarrhea from 28.5% to 11.9% (relative risk [RR]: 0.44 [95% CI: 0.25-77]; P ϭ .006).…”

Section: Prevention Of Antibiotic-associated Diarrheamentioning

confidence: 99%

Probiotics and Prebiotics in Pediatrics

Thomas¹,

Greer²

2010

Pediatrics

356

220

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This clinical report reviews the currently known health benefits of probiotic and prebiotic products, including those added to commercially available infant formula and other food products for use in children. Probiotics are supplements or foods that contain viable microorganisms that cause alterations of the microflora of the host. Use of probiotics has been shown to be modestly effective in randomized clinical trials (RCTs) in (1) treating acute viral gastroenteritis in healthy children; and (2) preventing antibiotic-associated diarrhea in healthy children. There is some evidence that probiotics prevent necrotizing enterocolitis in very low birth weight infants (birth weight between 1000 and 1500 g), but more studies are needed. The results of RCTs in which probiotics were used to treat childhood Helicobacter pylori gastritis, irritable bowel syndrome, chronic ulcerative colitis, and infantile colic, as well as in preventing childhood atopy, although encouraging, are preliminary and require further confirmation. Probiotics have not been proven to be beneficial in treating or preventing human cancers or in treating children with Crohn disease. There are also safety concerns with the use of probiotics in infants and children who are immunocompromised, chronically debilitated, or seriously ill with indwelling medical devices. Prebiotics are supplements or foods that contain a nondigestible food ingredient that selectively stimulates the favorable growth and/or activity of indigenous probiotic bacteria. Human milk contains substantial quantities of prebiotics. There is a paucity of RCTs examining prebiotics in children, although there may be some long-term benefit of prebiotics for the prevention of atopic eczema and common infections in healthy infants. Confirmatory well-designed clinical research studies are necessary.

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Section: Prevention Of Antibiotic-associated Diarrheamentioning

confidence: 99%

Probiotics and Prebiotics in Pediatrics

Thomas¹,

Greer²

2010

Pediatrics

356

220

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“…Lactobacillus GG, Saccharomyces boulardii ) significantly reduce the risk of diarrhea in children treated with antibiotics [8, 9]. Other meta-analyses have shown that probiotics are modestly effective also in the general population [10,11,12,13]. …”

Section: Introductionmentioning

confidence: 99%

Bifidobacterium longum PL03, Lactobacillus rhamnosus KL53A, and Lactobacillus plantarum PL02 in the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Controlled Pilot Trial

et al. 2008

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Aim: To determine the efficacy of a combination of Bifidobacterium longum PL03, Lactobacillus rhamnosus KL53A and Lactobacillus plantarum PL02 for the prevention of antibiotic-associated diarrhea in children. Methods: Seventy-eight children (age: 5 months to 16 years) with otitis media, and/or respiratory tract infections, and/or urinary tract infections were enrolled in a double-blind randomized control trial in which they received standard antibiotic treatment plus a food supplement containing 10⁸ colony-forming units of B. longum, L. rhamnosus and L. plantarum (n = 40) or a placebo (n = 38) orally twice daily for the duration of antibiotic treatment. Results: Patients receiving probiotics had a similar rate of diarrhea (≧3 loose or watery stools/day for ≧48 h occurring during or up to 2 weeks after the antibiotic therapy) as those receiving placebo (relative risk 0.5, 95% CI 0.06–3.5). The mean number of stools per day was significantly lower in the experimental group (mean difference –0.3 stool/day, 95% CI –0.5 to –0.07). No adverse events were reported. Conclusion: The administration of the 3 probiotics did not significantly alter the rate of diarrhea, although it reduced the frequency of stools per day. As the overall frequency of diarrhea was surprisingly low, these results should be interpreted with caution.

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“…Unfortunately, the studies differ in design, sample population, types of antibiotics studied and formulation of bacterial enriched drinks, end points and definition of diarrhoea. Therefore, it is difficult to assess the efficacy of probiotics on AAD (Hawrelak et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Prevention of antibiotic-associated diarrhoea by a fermented probiotic milk drink

et al. 2007

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Objective: To study the preventive effect of a milk drink fermented with multistrain probiotics on antibiotic associated diarrhoea (AAD). Design: Double-blind placebo controlled study. Setting: University Hospital of North Norway. Subjects and methods: Of 853 patients treated with antibiotics, 87 met the inclusion criteria, and were randomized to ingestion of a fermented milk drink containing LGG, La-5 and Bb-12 (n ¼ 46) or placebo with heat-killed bacteria (n ¼ 41), during a period of 14 days. A diary was recorded, and stool samples were collected for microbiological analyses. Results: Sixty-three patients completed the study according to the protocol; two patients (5.9%) in the treatment group and eight (27.6%) in the placebo group developed AAD (P ¼ 0.035). The relative risk of developing AAD was 0.21 (95% confidence interval: 0.05-0.93) when given probiotic milk drink. Conclusion: A fermented multistrain probiotic milk drink may prevent four of five cases of AAD in adult hospitalized patients. Sponsorship: TINE BA, Oslo, Norway.

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Is <i>Lactobacillus rhamnosus</i> GG Effective in Preventing the Onset of Antibiotic-Associated Diarrhoea: A Systematic Review

Cited by 77 publications

References 41 publications

Probiotics and Prebiotics in Pediatrics

Probiotics and Prebiotics in Pediatrics

<i>Bifidobacterium longum</i> PL03, <i>Lactobacillus rhamnosus</i> KL53A, and <i>Lactobacillus plantarum</i> PL02 in the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Controlled Pilot Trial

Prevention of antibiotic-associated diarrhoea by a fermented probiotic milk drink

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