Is long-term follow-up without surgical treatment a valid option for hepatic alveolar echinococcosis?

Maimaitinijiati, Yusufukadier; Yuan, Meng; Chen, Xiong

doi:10.3748/wjg.v28.i24.2775

Cited by 2 publications

(3 citation statements)

References 9 publications

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“…HAE is a zoonotic disease with severe clinical manifestations and poor prognosis. Currently, radical surgery combined with albendazole medication remains the most ideal treatment option for HAE patients [25][26] . In recent years, numerous studies have gradually revealed the ability of LncRNAs to regulate the expression of target genes through various pathways, playing a significant role in promoting the occurrence, development, and metastasis of tumors.…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of high-throughput sequencing-based lncRNA-mediated ceRNA network in Hepatic Alveolar Echinococcosis

Liu,

Shang,

Wang

et al. 2024

Preprint

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BackgroundNumerous studies have indicated that long non-coding RNAs (lncRNAs) can modulate the expression of target gene mRNAs by adsorbing microRNAs (miRNAs). The lncRNA–miRNA–mRNA ceRNA network has been theorized to play an indispensable role in many types of tumors, and has been garnering increasing attention. However, the role of the lncRNA-associated ceRNA regulatory network in Hepatic Alveolar Echinococcosis (HAE) remains unclear and requires further exploration.MethodsIn this study, high-throughput sequencing was performed on lesion tissues and adjacent tissues from three patients with Hepatic Alveolar Echinococcosis (HAE) to identify differentially expressed RNAs. We utilized Cytoscape (version 3.10.1) to construct the lncRNA-miRNA-mRNA ceRNA network based on the interactions from the miRcode, miRTarBase, miRDB, and TargetScan databases, and identified hub lncRNAs from within the ceRNA network. Through the use of the “clusterProfiler” package in R, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotations for the DEGs (Differentially Expressed Genes) within the ceRNA network. Concurrently, we utilized these DEGs to construct a protein-protein interaction network (PPI). Finally, an analysis was conducted on the PCBP1-AS1-miR-20b-5p/CAPRIN2 axis within the ceRNA network.ResultsIn HAE, a total of 979 differentially expressed lncRNAs (DELncRNAs) and 870 differentially expressed mRNAs (DEmRNAs) were identified. An HAE-specific ceRNA network comprising 11 lncRNAs, 21 miRNAs, and 56 mRNAs was established, and analysis of this network led to the construction of a sub-network associated with hub lncRNAs. GO and KEGG pathway analyses indicated that the HAE-specific ceRNA network is related to molecular functions and pathways associated with cancer. Subsequent experiments using qPCR and dual-luciferase assays validated the interactions between PCBP1-AS1 and miR-20b-5p, as well as between miR-20b-5p and CAPRIN2. Analysis of the target gene in relation to clinical characteristics of HAE patients suggested that the PCBP1-AS1-miR-20b-5p/CAPRIN2 axis may influence the development of HAE.ConclusionIn this study, we described the gene regulation within the lncRNA-miRNA-mRNA ceRNA network during the development of Hepatic Alveolar Echinococcosis (HAE), which contributes to a deeper exploration of the molecular mechanisms underlying HAE. Additionally, we discovered that PCBP1-AS1 may regulate the expression of CAPRIN2 by adsorbing miR-20b-5p, affecting the onset and progression of HAE. PCBP1-AS1 could potentially serve as a useful target for the diagnosis and treatment of HAE.

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Section: Discussionmentioning

confidence: 99%

Integrated analysis of high-throughput sequencing-based lncRNA-mediated ceRNA network in Hepatic Alveolar Echinococcosis

Liu,

Shang,

Wang

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…Treatment options for echinococcosis include surgery, chemotherapy, and a "watch-andwait" approach (Wen et al 2019). However, the optimal preventive and curative methods for different types or classifications of echinococcosis remain limited and controversial (Stojković et al 2018;Maimaitinijiati et al 2022). Emphasis on prevention of infection and disease occurrence could contribute to the reduction of the global echinococcosis burden.…”

Section: Introductionmentioning

confidence: 99%

“…2018; Maimaitinijiati et al . 2022). Emphasis on prevention of infection and disease occurrence could contribute to the reduction of the global echinococcosis burden.…”

Section: Introductionmentioning

confidence: 99%

China’s prevention and control experience of echinococcosis: A 19-year retrospective

Gu,

Hu,

Guo

et al. 2024

J. Helminthol.

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Echinococcosis poses a significant threat to public health. The Chinese government has implemented prevention and control measures to mitigate the impact of the disease. By analyzing data from the Chinese Center for Disease Control and Prevention and the State Council of the People’s Republic of China, we found that implementation of these measures has reduced the infection rate by nearly 50% between 2004 to 2022 (from 0.3975 to 0.1944 per 100,000 person-years). Nonetheless, some regions still bear a significant disease burden, and lack of detailed information limites further evaluation of the effects on both alveolar and cystic echinococcosis. Our analysis supports the continuing implementation of these measures and suggests that enhanced wildlife management, case-based strategies, and surveillance systems will facilitate disease control.

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Is long-term follow-up without surgical treatment a valid option for hepatic alveolar echinococcosis?

Cited by 2 publications

References 9 publications

Integrated analysis of high-throughput sequencing-based lncRNA-mediated ceRNA network in Hepatic Alveolar Echinococcosis

Integrated analysis of high-throughput sequencing-based lncRNA-mediated ceRNA network in Hepatic Alveolar Echinococcosis

China’s prevention and control experience of echinococcosis: A 19-year retrospective

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