Is living in a region with high groundwater arsenic contamination associated with adverse reproductive health outcomes? An analysis using nationally representative data from India

Pinchoff, Jessie; Monseur, Brent; Desai, Sapna; Koons, Katelyn; Alvero, Ruben; Hindin, Michelle J.

doi:10.1016/j.ijheh.2021.113883

Cited by 12 publications

(4 citation statements)

References 20 publications

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“…Relevant epidemiological investigations from Taiwan, China have suggested that blood concentrations of As were significantly higher in infertile women than in pregnant women ( 14 ). Pinchoff et al ( 32 ) examined reproductive outcomes in Indian women and found that As-exposed areas exhibited higher rates of stillbirth, recurrent miscarriage, and infertility compared with unexposed areas. A study reported no correlation between blood As and fertility in New York State women ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Association between heavy metals exposure and infertility among American women aged 20–44 years: A cross-sectional analysis from 2013 to 2018 NHANES data

Lin

Lin²,

Qiu³

et al. 2023

Front. Public Health

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BackgroundInfertility has been confirmed as a significant medical and social problem. Heavy metal exposure refers to a risk factor for infertility, which is capable of damaging the reproductive system of males and females. However, heavy metal exposure and female infertility have rarely been investigated. The aim of this study was to analyze the association between heavy metal exposure and female infertility.MethodsA cross-sectional study using data from three cycles of the National Health and Nutrition Examination Survey (NHANES, 2013–2018) was performed. Female infertility was evaluated by positive responses to question rhq074 in the questionnaire. Cadmium (Cd), lead (Pb), mercury (Hg), and arsenic (As) levels in blood or urine were examined by inductively coupled plasma mass spectrometry. The correlation between heavy metal and female infertility was analyzed through weighted logistic regression.ResultsA total of 838 American women aged 20–44 years were covered in the study. Among all participants, 112 (13.37%) women were subjected to infertility. Urinary Cd and urinary As levels were significantly higher in infertile women than in control women (P < 0.05, P < 0.05). Urinary As showed a positive correlation with the prevalence of female infertility, and the risk of infertility rose with the increase of urinary As levels (P for trend = 0.045). Urinary Cd was associated with female infertility in some weighted logistic regression (Crude, Q2: OR = 3.99, 95% CI 1.82, 8.74, Q3: OR = 2.90, 95% CI 1.42, 5.92. Model 1, Q2: OR = 3.68, 95% CI 1.64, 8.27, Q3: OR = 2.33, 95% CI 1.13, 4.48. Model 2, Q2: OR = 4.11, 95% CI 1.63, 10.07, Q3: OR = 2.44, 95% CI 1.07, 5.53. Model 3, Q2: OR = 3.77, 95% CI 1.52, 9.35). Moreover, blood Pb (OR = 1.52, 95% CI 1.07, 2.16), urinary Pb (OR = 1.68, 95% CI 1.11, 2.55), and urinary As (OR = 1.02, 95% CI 1.00, 1.03) were positively correlated with the risk of infertility in women aged 35–44 years. The blood Pb (OR = 1.67, 95% CI 1.16, 2.40, 2.49) and urinary Pb (OR = 1.54, 95% CI 1.00, 2.38) in women with BMI ≥25 were positively correlated with the risk of infertility.ConclusionsUrinary As was significantly associated with female infertility, and the risk of infertility increased with higher urinary As levels. To some extent, urinary Cd was correlated with infertility. Blood/urine Pb was related to infertility in advanced age and overweight/obese women. The results of this study need to be further validated in future prospective studies.

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Section: Discussionmentioning

confidence: 99%

Association between heavy metals exposure and infertility among American women aged 20–44 years: A cross-sectional analysis from 2013 to 2018 NHANES data

Lin

Lin²,

Qiu³

et al. 2023

Front. Public Health

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“…22 According to a survey, there was a significant positive correlation between arsenic concentration in groundwater and infertility rate in India. 23 After oral intake As (8 mg/kg/d) for 56 days, the sperm count and average diameter of seminiferous tubules in mice were significantly decreased. 24 A recent study has shown that As at 5 mg/kg induces male mice testis oxidative stress, apoptosis, and inflammation.…”

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confidence: 95%

“…In Mexico, scientists have detected As in the blood of pregnant women and the umbilical cord of newborns, which should be an alarm that pregnant women and babies are at risk of As exposure 22 . According to a survey, there was a significant positive correlation between arsenic concentration in groundwater and infertility rate in India 23 . After oral intake As (8 mg/kg/d) for 56 days, the sperm count and average diameter of seminiferous tubules in mice were significantly decreased 24 .…”

Section: Introductionmentioning

confidence: 99%

Arsenic and polystyrene‐nano plastics co‐exposure induced testicular toxicity: Triggers oxidative stress and promotes apoptosis and inflammation in mice

Rao,

Qiao,

Zhong

et al. 2023

Environmental Toxicology

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Co‐existing of polystyrene‐nano plastics (PSNPs) and arsenic (As) in the environment caused a horrendous risk to human health. However, the potential mechanism of PSNPs and As combination induced testicular toxicity in mammals has not been elucidated. Therefore, we first explore the testicular toxicity and the potential mechanism in male Kunming mice exposed to As or/and PSNPs. Results revealed that compared to the As or PSNPs group, the combined group showed more significant testicular toxicity. Specifically, As and PSNPs combination induced irregular spermatozoa array and blood–testis barrier disruption. Simultaneously, As and PSNPs co‐exposure also exacerbated oxidative stress, including increasing the MDA content, and down‐regulating expression of Nrf‐2, HO‐1, SOD‐1, and Trx. PSNPs and As combination also triggered testicular apoptosis, containing changes in apoptotic factors (P53, Bax, Bcl‐2, Cytc, Caspase‐8, Caspase‐9, and Caspase‐3). Furthermore, co‐exposed to As and PSNPs aggravated inflammatory damage characterized by targeted phosphorylation of NF‐κB and degradation of I‐κB. In summary, our results strongly confirmed As + PSNPs co‐exposure induced the synergistic toxicity of testis through excessive oxidative stress, apoptosis, and inflammation, which could offer a new sight into the mechanism of environmental pollutants co‐exposure induced male reproductive toxicity.

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“…Chronic exposure to arsenic harms several organ systems and has been linked to diabetes, hypertension, peripheral blood vessel problems, skin, bladder, kidney, and lung malignancies among other cancers(Xu et al,2020). Studies by(Pinchoff et al,2022) discovered a direct link between arsenic, Recurrent pregnancy loss and infertility.…”

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confidence: 99%

The Impacts on Consumer Health from Dug Well Contamination - A Crucial Drinking Water Source

Thaniem¹,

Prakash²,

Muniyandi³

2022

IJRASET

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Main objective of this review is to analyse potential sources of pollution, constituents, consumer health risks related to contaminated drinking water, and remediation strategies. Dug wells with poorly protected well mouth-covering or unlined wells are more susceptible to biological and chemical contamination. Physical irregularities in the lining and covering of the well act as a door to the entry of pollutants into the well. Residential, municipal, commercial, industrial, and agricultural activities can have an impact on ground water quality. Agriculture is one of the most common human activities that have an impact on both surface and groundwater. Water resource quality is determined by geological characteristics such as soil kinds, topography slope, plant roots, water dissolution with minerals/soils, and the radioactive decay of elements. Septic tanks, pit latrines, and sewer systems are the main source of faecal contamination in the groundwater system. Pesticides, fertilisers, and livestock dung frequently introduce heavy metals into aquifers, posing a direct hazard to human health. Waterborne diseases such as diarrhoea, cholera, syphilis, and typhoid have been linked to a lack of adequate water. Drinking water containing various anions and heavy metals, such as Cd, Cr, Co, Hg, Ni, Pb, Zn, and others, has a substantial negative impact on human health. Drinking water treatment removes impurities from the source water, making it safe to drink. The long-term goal of decontamination is to detect and remove hazardous compounds from water cost-effectively and reliably.

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Is living in a region with high groundwater arsenic contamination associated with adverse reproductive health outcomes? An analysis using nationally representative data from India

Cited by 12 publications

References 20 publications

Association between heavy metals exposure and infertility among American women aged 20–44 years: A cross-sectional analysis from 2013 to 2018 NHANES data

Association between heavy metals exposure and infertility among American women aged 20–44 years: A cross-sectional analysis from 2013 to 2018 NHANES data

Arsenic and polystyrene‐nano plastics co‐exposure induced testicular toxicity: Triggers oxidative stress and promotes apoptosis and inflammation in mice

The Impacts on Consumer Health from Dug Well Contamination - A Crucial Drinking Water Source

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