Is liquid nitrogen recycled bone and vascular fibula combination the biological reconstruction of choice in lower extremity long bone tumor‐related defects?

Abstract

IntroductionCombination techniques, which encompass the combined use of vascularized bone grafts with massive allografts or autografts (recycled bone grafts), are especially important in the biological reconstruction of tumor‐related lower extremity long bone defects. Liquid nitrogen recycled bone (frozen autograft) and free vascular fibula graft (FVFG) combination, which was coined as the “frozen hotdog (FH)” method by the authors, has not been as widely used nor its outcomes reported for significantly sized patient groups. This study aims to provide an answer to whether FH is a safe and effective reconstructive tool for limb salvage in malignant tumors of the lower extremity regarding radiological, functional, and oncological outcomes.Patients and MethodsSixty‐six (male/female: 33/33) patients, who underwent FH reconstruction for tumor‐related massive defects of lower extremity long bones between 2006 and 2020, were retrospectively analyzed. The mean age was 15.8 (3.8–46.7) years. The most common tumor localizations were distal femur (42.4%) and proximal tibia (21.2%) while classic osteosarcoma and Ewing's sarcoma were the most common pathologies (60.6% and 22.7%, respectively). Mean resection and FVFG lengths were 160 (90–320) mm and 192 (125–350) mm, respectively. The mean follow‐up was 73.9 (24–192) months.ResultsThe mean MSTS score was 25.4 (15–30) and the mean ISOLS radiographic score was 22.6 (13–24). Mean time to full weight bearing without any assistive devices was 15.4 (6–40) months and the median time was 12 months. MSTS score negatively correlated with resected segment length and vascular fibula length (p < 0.001; p = 0.006). Although full contact apposition of the FH segment correlated with earlier full weight bearing compared to partial apposition (mean 13.7 vs. 17.9 months) (p = 0.042), the quality of reduction did not affect the ISOLS radiographic score at LFU. Overall limb survival rate was 96.3% at 5 and 10 years while FH survival rate was 91.0% and 88.1% at 5 and 10 years. Local recurrence‐free survival rates were 88.8% and 85.9%, and overall survival was 89.9% and 86.1% at 5 and 10 years, respectively. Limb length discrepancy was the most common complication with 34 (51.5%) patients while shell nonunion was seen in 21 (31.8%) patients and graft fracture in 6 (9.1%).ConclusionThe “FH” method is a safe, effective, and extremely cost‐efficient reconstructive tool for tumor‐related lower extremity long bone defects. Patient compliance to protracted weight‐bearing, ensuring the vitality of the FVFG, and achieving an oncologically safe resection are key factors for a successful outcome.

Frozen inactivated autograft replantation for bone and soft tissue sarcomas

“…Another noteworthy issue is the effect of age on the healing of inactivated bones. Currently, a small number of studies have focused on this issue, but due to the small sample size, it is not possible to draw definitive conclusions (21,22). In this study, age did not seem to be a relevant factor for inactivated bone healing.…”

Oncology

“…This study team from Istanbul (Turkey) asked the question: is frozen autograft and free vascular fibula graft (FVFG) the best combination? 3 They argue that this preparation pairs the strength of the massive bone graft with the biological activity of the vascularized bone, known as a ‘frozen hotdog’ (FH) reconstruction. The authors evaluated 66 patients, all treated in this way with a mean age of 15.8 years.…”