Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury?

Sabour, Hadis; Javidan, Abbas Norouzi; Latifi, Sahar; Hadian, Mohammad Reza; Razavi, Seyed-Hassan Emami; Shidfar, Farzad; Vafa, Mohammadreza; Meybodi, Hamidreza Aghaei

doi:10.1155/2014/695014

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…A few studies found no association and/or a positive association with serum cholesterol and LDL cholesterol ( 98 – 101 ). The summarized data from all the studies indicate that there is an existence of an inconsistent relationship for the case of HDL cholesterol and BMD ( 6 , 99 , 100 , 102 ). In several clinical trials, but not in all, the use of statins have been associated with a reduction of fracture risk, and the patients taking statins having a higher BMD than those who do not ( 103 – 105 ).…”

Section: Discussionmentioning

confidence: 99%

High Cholesterol Deteriorates Bone Health: New Insights into Molecular Mechanisms

Mandal

2015

Front. Endocrinol.

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Many epidemiological studies show a positive connection between cardiovascular diseases and risk of osteoporosis, suggesting a role of hyperlipidemia and/or hypercholesterolemia in regulating osteoporosis. The majority of the studies indicated a correlation between high cholesterol and high LDL-cholesterol level with low bone mineral density, a strong predictor of osteoporosis. Similarly, bone metastasis is a serious complication of cancer for patients. Several epidemiological and basic studies have established that high cholesterol is associated with increased cancer risk. Moreover, osteoporotic bone environment predisposes the cancer cells for metastatic growth in the bone microenvironment. This review focuses on how cholesterol and cholesterol-lowering drugs (statins) regulate the functions of bone residential osteoblast and osteoclast cells to augment or to prevent bone deterioration. Moreover, this study provides an insight into molecular mechanisms of cholesterol-mediated bone deterioration. It also proposes a potential mechanism by which cellular cholesterol boosts cancer-induced bone metastasis.

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Section: Discussionmentioning

confidence: 99%

High Cholesterol Deteriorates Bone Health: New Insights into Molecular Mechanisms

Mandal

2015

Front. Endocrinol.

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Section: Discussionmentioning

confidence: 99%

“…The association between serum lipids and BMD has been investigated in previous studies [5][6][7]. Hadis et al [5] investigated the relationships between serum lipids and BMD in 85 male patients with spinal cord injury (SCI). As a result of this study a positive correlation between HDL and femoral neck BMD (r = 0.33, p = 0.004) was found although any a relation between others and BMD scores had no.…”

Section: Discussionmentioning

confidence: 99%

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The association between lipid profile and bone mineral density in subjects with ankylosing spondylitis

Sargın

Gürer

Öztürk

2019

The European Research Journal

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Objective: This study aims to investigate the relationship between serum lipids and bone mineral density in ankylosing spondylitis patients. Methods: A total of 94 ankylosing spondylitis patients fulfilling the 1984 Modified New York Criteria who had serum lipid levels and bone mineral density scores in medical records were included in this study. These patients treated with nonsteroid antiinflammatory drugs. Their files were examined in detail. Later demographic and laboratory features were recorded to the research form. Dual-energy X-ray absorptiometry was used to assess bone mineral density in two bone sites of femur (neck, intertrochanteric zone and trochanter) and spinal lumbar vertebras (Lumbar 1-Lumbar 4). Results: Significant and positive correlation was found between high density lipoprotein and femoral neck bone mineral density (r = 0.356, p = 0.021) in osteopenic group and in osteoporotic group (r = 0.005, p = 0.040). Conclusion: According to our study significant and positive correlations are found between high density lipoprotein and femoral neck bone mineral density in osteopenic and osteoporotic group. However, we believe that more studies are needed about this research.

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“…In hepatocyte lipids are stored or metabolized to produce energy or made available for other tissues. It has been shown a strict relationship among serum lipid profile, bone and adipose tissues, for instance, a positive correlation has been found between HDL and femoral neck mineral density, and a negative association between HDL and osteocalcin in male subject with spinal cord injury [31]. Moreover, bone cells have been shown to utilize lipid metabolism, while previously it was assumed that bone cells utilized mainly glucose metabolism [32].…”

Section: Lipidsmentioning

confidence: 99%

Effects of Nutrients, Mainly from Mediterranean Dietary Foods, on Mesenchymal Stem Derived Cells: Growth or Differentiation

Ammendola¹,

Cocchiola²,

Lopreiato³

et al. 2018

Int J Clin Nutr Diet

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During the last decade the interest for the mesenchymal cells is growing due to their possible uses in therapies to treat certain degenerative pathologies. Mesenchymal stem cells have been found in the bone marrow and they have been shown to be responsible for bone repair and fat cells production. Mesenchymal stromal cells can be obtained from a wide variety of tissues in addition to bone marrow and can differentiate into many other cell types. The study of cell differentiation and programming provides new models for drug discovery and cell therapy that now overcomes gene therapy. Senescence, cancer development and degenerative diseases depend on mesenchymal cells contribution to tissue homeostasis. On the other hand, diet and life style are included among risk factors, which can contribute to the success of pharmacological treatments. This review focuses on nutrients from Mediterranean diet and supplements, which have been shown to influence mesenchymal stem cells and cells derived from them. Dietary intake of nutrients impairs both in vitro and in vivo observations, this review aims to gather the results about the effects of food compounds on mesenchymal cells from which adipocytes and osteoblasts derive. Amino acids and proteins, carbohydrates, lipids, fatty acids and vegetable secondary metabolites, differently act on mesenchymal cells bearing on modulation of gene expression and controlling the fate of cell lineages. Remarkable, the analysis of literature shows that the main effect of nutrients on mesenchymal cells is the stimulation of transcription factors which address the cells toward proliferation or differentiation. For instance, carbohydrates, simple or complex, and lipids appear to stimulate the PPAR receptors, whereas proteins and amino acids result to act on the mTOR system and they can also stimulate the MyoD-1 transcription factor and cooperating proteins. In conclusion, nutrients can promote cell growth and differentiation of mesenchymal cells.

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Is Lipid Profile Associated with Bone Mineral Density and Bone Formation in Subjects with Spinal Cord Injury?

Cited by 6 publications

References 33 publications

High Cholesterol Deteriorates Bone Health: New Insights into Molecular Mechanisms

High Cholesterol Deteriorates Bone Health: New Insights into Molecular Mechanisms

The association between lipid profile and bone mineral density in subjects with ankylosing spondylitis

Effects of Nutrients, Mainly from Mediterranean Dietary Foods, on Mesenchymal Stem Derived Cells: Growth or Differentiation

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