Is Lipase Supplementation before a High Fat Meal Helpful to Patients with Functional Dyspepsia?

Park, Seon-Young; Rew, Jong Sun

doi:10.5009/gnl15206

Cited by 2 publications

(3 citation statements)

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“…Furthermore, FD patients with delayed gastric emptying showed significantly more pre- and postprandial tachygastria when compared with patients having normal gastric emptying. 58 Hence, based on earlier study findings 55 , 56 and current study observations, it would be possible that enzyme supplementation may provide relief to FD patients by controlling some of the common dyspeptic symptoms. However, further studies are warranted in this regard to delineate the underlying mechanism.…”

Section: Discussionmentioning

confidence: 57%

“… 24 , 55 Although digestive enzyme deficiency has been linked to causing dyspepsia, the exact mechanism involved is not clearly known because of the frequency and multiplicity of the etiopathogenesis of enzyme deficiency. However, based on the reported observations 17 , 55 , 56 and efficacy outcomes of the current study, we hypothesize that digestive enzyme supplementation enhances the normal actions of digestive enzymes during the gastric phase of food digestion, which in turn results in decreased varying dyspepsia symptoms in FD patients.…”

Section: Discussionmentioning

confidence: 70%

“…MEC used in the present study is a unique combination of five enzymes (lipase, protease, α -amylase, lactase, and cellulose) of fungal and bacterial origin, whereas most of the reported studies have used either different enzyme combinations of both animal and microbial origin, 17 , 23 , 32 in combination with drugs or micronutrients, 17 , 22 , 59 or standalone enzyme preparations. 56 Furthermore, to the best of our knowledge, this study is the first to report on the safety and efficacy of multienzyme preparation, at least having the abovementioned five enzymes of microbial origin, in the management of FD symptoms in the Indian population. Moreover, different self-completion questionnaires for patients (SF-LDQ, NDI-SF, VAS, and GDSS) were also used to determine the effectiveness of MEC, which distinguish the current study from the previous trials, wherein the efficacy was mostly assessed only by physicians.…”

Section: Discussionmentioning

confidence: 83%

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Evaluation of the Safety and Efficacy of a Multienzyme Complex in Patients with Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study

Majeed

Nagabhushanam

et al. 2018

Journal of Medicinal Food

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Functional dyspepsia (FD) is a highly prevalent disorder having nonspecific symptoms and varied pathophysiology. Its treatment remains a challenge as therapeutic options are limited, unsatisfactory, and elusive. Thus, safety and efficacy of DigeZyme®, a proprietary multienzyme complex (MEC), was evaluated as a dietary supplement in FD patients. In this randomized, double-blind, placebo-controlled, parallel-group study, 40 patients were randomly assigned (1:1 ratio) to receive either MEC (50 mg, TID; n = 20) or placebo (n = 20) for 60 days. Reports of adverse or serious adverse events (AEs), abnormal results of vital signs, abnormal findings during physical examination, and abnormal laboratory investigations were monitored closely. Efficacy measures were change in Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ), Nepean Dyspepsia Index-Short Form (NDI-SF), Visual Analog Scale (VAS), Clinical Global Impression Severity Rating Scale (CGI-S), and Glasgow Dyspepsia Severity Score (GDSS) at baseline and follow-up visits on day 15, 30, and 60. Supplementation with MEC was associated with statistically significant differences (P value ranging from .0401 to .0033) in all efficacy parameters compared with placebo. The between-group comparison also revealed that MEC supplement had a significantly greater effect (P < .001) versus placebo. No investigation product-related AEs were reported. There were no clinically significant abnormalities in physical findings and no statistically significant changes in biochemical and hematological parameters, vital signs, body weight, and body mass index observed between the two groups at baseline and follow-up visits. MEC supplementation represents an effective and safe alternative to manage dyspepsia symptoms in FD patients.

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Section: Discussionmentioning

confidence: 57%