Is leptin a predictive factor in patients with lung cancer?

Song, Cuihong; Liao, Jie; Deng, Zihui; Zhang, Jinying; Xue, Hong; Li, Yongming; Chen, Liang; Han, Ming; Zhang, Kai; Yan, Gaoliang

doi:10.1016/j.clinbiochem.2013.12.003

Cited by 20 publications

(25 citation statements)

References 9 publications

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“…On the contrary, there are some studies with elevated levels of leptin (7,8). Our study results also show that there was a correlation between BMI and leptin levels, but no correlation between stage disease and leptin levels.…”

Section: Discussionsupporting

confidence: 32%

“…Leptin increases the infl ammation and carcinogenic risk by affecting both innate and adaptive immunity (5). Studies showed that functional polymorphism in leptin and leptin receptor gene increases susceptibility for non-small cell lung cancer (NSCLC) and serum levels of leptin is high in lung cancer patients and correlates with disease stage (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

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Are serum leptin levels a prognostic factor in advanced lung cancer?

Anar¹,

Deniz²,

Erol³

et al. 2017

BLL

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AIM: The aim of the present study was to evaluate pre-treatment concentrations of leptin in patients with advanced lung cancer and to investigate possible associations between their levels and clinicopathological variables, response to therapy and overall survival. MATERIAL AND METHODS: There are 71 previously untreated patients with cytological or histological evidence of primary lung cancer who were admitted to the oncology department between November 2013 and August 2014. Forty-fi ve healthy individuals with age, sex and BMI matching the lung cancer patients, were recruited to take part in the study as a control group. Leptin levels were measured quantitatively by using a microELISA kit. RESULTS: The serum leptin levels at diagnosis were signifi cantly lower in lung cancer patients than those in control subjects (4.75 ± 4.91 ng/ml, 9.67 ± 8.02 ng/ml; p < 0.001). We did not fi nd any signifi cant difference in leptin values related to clinicopathological parameters such as ECOG PS, weight loss, histological type, disease stage and TNM classifi cation. Nevertheless, we demonstrated a signifi cant correlation between serum leptin levels and BMI in lung cancer patients (correlation coeffi cient: 0.303; p > 0.010). The analysis of serum leptin values did not show any association with the overall survival of the patients. CONCLUSION: Our results showed that the serum leptin level has no prognostic indications in advanced lung cancer patients. Leptin is decreased in lung cancer, and there is lack of correlation with tumour-related factors including prognosis. Therefore, leptin is not a useful clinical marker in lung cancer (Tab. 2, Fig. 2, Ref. 22). Text in PDF www.elis.sk.

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Section: Discussionsupporting

confidence: 32%

Section: Introductionmentioning

confidence: 99%

Are serum leptin levels a prognostic factor in advanced lung cancer?

Anar¹,

Deniz²,

Erol³

et al. 2017

BLL

View full text Add to dashboard Cite

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“…Studies have identified that adipokines affect various pro-neoplastic mechanisms, including inflammation, cell growth and proliferation (12,13). Studies have also demonstrated that adipokines are promising predictors of risk and progression in various types of cancer (14,15). Such evidence suggests that adipokines contribute to the initiation of carcinogenesis and tumor progression.…”

Section: Introductionmentioning

confidence: 99%

“…Leptin is a multifunctional peptide hormone that regulates energy expenditure (25), promotes proliferation (26) and angiogenesis (27), and inhibits cell apoptosis (28). Studies have demonstrated that leptin levels are higher in lung cancer (15), breast cancer (29) and RCC (30), whilst other studies have reported that serum leptin levels are inversely associated with RCC risk (23) or are not significantly associated with RCC (24,31). These contradictory results, and the serum level features, suggest that further investigation is required.…”

Section: A B C D Ementioning

confidence: 99%

Association of leptin, visfatin, apelin, resistin and adiponectin with clear cell renal cell carcinoma

Zhang

Zou

et al. 2016

Oncology Letters

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Abstract.Although an association between obesity and the occurrence of renal cell carcinoma (RCC) has been identified, the mechanism by which obesity functions to increase this risk of cancer remains unclear. Leptin, visfatin, apelin, resistin and adiponectin are peptide hormones secreted by adipocytes; it is considered that these may affect RCC development by exerting effects on proliferation, cell growth and inflammation. The aim of the present study was to investigate the association between the aforementioned adipokine genes and clear cell RCC (CC-RCC). The GSE6344 dataset was downloaded from the Gene Expression Omnibus database, and the relative expression levels of the adipokine genes were analyzed. To verify the results of the mRNA microarray, 77 paired samples of CC-RCC and corresponding adjacent normal tissue were allocated into two groups. The extraction of total RNA was conducted, and the mRNA expression of adipokine genes was analyzed using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The data from the GSE6344 dataset indicated that the expression of visfatin and apelin was upregulated (P<0.0001 and P<0.01, respectively), and adiponectin was downregulated (P<0.001) in the CC-RCC tissues compared with the adjacent normal tissues. The data from RT-qPCR demonstrated that visfatin and resistin gene expression was increased (P<0.01 and P<0.05, respectively) in the CC-RCC tissues. Furthermore, the mRNA expression level of leptin and adiponectin in the adjacent normal tissue was higher than those in the cancer tissue (P<0.01). The current study verifies that visfatin and adiponectin are associated with an increased risk of CC-RCC, which presents further insights into the molecular mechanisms of CC-RCC tumorigenesis.

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“…Recently, the expression of leptin, an adipocyte-derived signaling factor, has been observed in human lung tissues (Vernooy et al, 2009;Vernooy et al, 2013). Furthermore, a variety of studies have implicated serum leptin levels in the pathogenesis of NSCLC (Terzidis et al, 2009;Song et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Relationship between serum leptin levels and non-small cell lung carcinoma: a meta-analysis

et al. 2015

Genet. Mol. Res.

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ABSTRACT. In this study, we analyzed the association between serum leptin levels and non-small cell lung carcinoma (NSCLC). By examining English and Chinese databases, we identified potential relevant studies for statistical analysis. Human-associated case-control studies evaluating the association between serum leptin levels and NSCLC according to the random-effect model were retrieved and extracted data were statistically analyzed. We identified 7 case-control studies evaluating the correlation between serum leptin levels and NSCLC, which included 705 subjects (390 NSCLC patients and 315 healthy participants). Negative associations were investigated between serum leptin levels and NSCLC [standardized mean difference (SMD) = 0.96, 95% confidence interval (CI) = 0.13-1.79, P = 0.023). Ethnicity-stratified analysis revealed there was no elevated leptin serum levels in NSCLC development in both Asians (SMD = 0.34, 95%CI = -0.10-0.79, P = 0.132) and Caucasians (SMD = 1.42, 95%CI = -0.09-2.93, P = 0.064). Sample size-stratified analysis of the association between serum leptin levels and NSCLC were found in studies of small sample size (SMD = 0.73, 95%CI = 0.04-1.41, P = 0.038), but not in studies of large sample size (SMD = 1.24, 95%CI = -0.52-3.01, P = 0.166). In the method- stratified subgroup analysis, serum leptin level was not correlated with NSCLC using a immunoradiometric assay method (SMD = 0.82, 95%CI = -1.38-3.03, P = 0.465). Determining the levels of the blood-based marker leptin may provide predictive information for NSCLC diagnosis.

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Is leptin a predictive factor in patients with lung cancer?

Cited by 20 publications

References 9 publications

Are serum leptin levels a prognostic factor in advanced lung cancer?

Are serum leptin levels a prognostic factor in advanced lung cancer?

Association of leptin, visfatin, apelin, resistin and adiponectin with clear cell renal cell carcinoma

Relationship between serum leptin levels and non-small cell lung carcinoma: a meta-analysis

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