Is Legg-Calvé-Perthes Disease a Local Manifestation of a Systemic Condition?

Abstract

Level III, prognostic study.

No increased mortality after total hip arthroplasty in patients with a history of pediatric hip disease: a matched, population-based cohort study on 4,043 patients

“…In this nationwide cohort study, we found a slightly attenuated 90-day and overall mortality after THA in patients with previous LCPD, SCFE, or DDH, but the attenuation of 90-day mortality was not statistically significant. Despite a higher comorbidity and mortality risk in patients with LCPD and SCFE in general (Hailer and Nilsson 2014, Perry et al 2017, Hailer and Hailer 2018, Hailer 2020 we found no notable alterations of the mortality risks after THA in such patients, even after stratifying the analyses on the underlying pediatric hip diseases.…”

“…The long-term outcome and revision rates after THA in patients with previous pediatric hip disease have been studied (Thillemann et al 2008, Traina et al 2011), but 90-day mortality and overall mortality after THA in these patients have not yet been investigated. Comorbidities, such as attention deficit hyperactivity disorder (ADHD), depression, cardiovascular disease, hypothyroidism, obesity, and coagulation abnormalities are more common in patients with LCPD and SCFE (Hailer and Nilsson 2014, Perry et al 2017, Hailer and Hailer 2018, Hailer 2020). In addition, patients with LCPD and SCFE have a higher overall mortality than the general population (Hailer andNilsson 2014, Hailer 2020).…”

“…Comorbidities, such as attention deficit hyperactivity disorder (ADHD), depression, cardiovascular disease, hypothyroidism, obesity, and coagulation abnormalities are more common in patients with LCPD and SCFE (Hailer and Nilsson 2014 , Perry et al. 2017 , Hailer and Hailer 2018 , Hailer 2020 ). In addition, patients with LCPD and SCFE have a higher overall mortality than the general population (Hailer and Nilsson 2014 , Hailer 2020 ).…”

High blood pressure and overweight in children with Legg-Calvé-Perthes disease: a nationwide population-based cohort study

“…In a Swedish study of almost 4600 school children from the ages 7–9 years the overall prevalence of overweight was estimated at 17% and obesity at 3% [ 24 ]. An increased risk of obesity in patients with LCPD has been demonstrated in a population-based cohort study in Sweden [ 17 ]. However, obesity in that cohort was mostly diagnosed after the diagnosis of LCPD.…”

“…In some older studies children with LCPD have been described with low birth weight, skeletal retardation [ 13 ] and short body length [ 14 ]. In contrast, more recent studies have reported normal body habitus [ 15 ] or a rather high prevalence of overweight and obesity [ 16 ], including a higher risk of developing obesity later in life with a mean delay of 10 years [ 17 ]. Furthermore, childhood obesity is a risk factor for childhood hypertension [ 18 ] and is associated with metabolic syndrome, cardiovascular diseases, type 2 diabetes and its associated complications [ 19 ].…”